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Product Description
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This protein may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Recombinant human GAD1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Biovision | P1153 | GAD1 human recombinant DataSheet
Biomolecule/Target: GAD1
Synonyms: CPSQ1, GAD, SCP, Glutamate decarboxylase 1
Alternates names: Mammotropin, Luterotropic hormone, Lutetropin, Prlr, PRL, luteotropic hormone, LTH, PRLR, PRL-R, PRL R
Taglines: Catalyzes the production of GABA
NCBI Gene ID #: 5617
NCBI Gene Symbol: PRL
Gene Source: Human
Accession #: P01236
Recombinant: Yes
Source: E.coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 23.3 kDa
Concentration: N/A
Appearance: Liquid
Physical form description: In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Reconstitution Instructions: Reconstitute in HO to a concentration of 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.
Amino acid sequence: N/A
