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Product Description
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is a transmembrane protein involved in the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Since HMG-CoA reductase catalyzes the rate limiting step in cholesterol synthesis, it is a primary target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol.
Biovision | 7841 | HMG-CoA Reductase Catalytic Domain GST Tagged human recombinant DataSheet
Biomolecule/Target: HMG-CoA Reductase
Synonyms: 3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR
Alternates names: Inhibin beta-1, FRP, FSH-releasing protein
Taglines: 90% Pure Human recombinant GST Tagged HMG-CoA Reductase Catalytic Domain, a primary target of statins.
NCBI Gene ID #: 3624
NCBI Gene Symbol: INHBA
Gene Source: Human
Accession #: P08476
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): The specific activity was determined to be > 1.0 Unit/mg by BioVisions HMG-CoA reductase Activity/Inhibitor Screening Kit (Cat # K588).
Biological activity: The activity is determined by the ability to induce cytoxicity of MPC-11 cells and is typically less than 2 ng/mL.
Results: < 2 ng/mL
Binding Capacity: N/A
Unit Definition: One unit is defined as the amount of enzyme required to convert 1.0 mole of NADPH to NADP+ per minute at 37 °C
Molecular Weight: 26.2 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from proprietary buffer containing BSA
Reconstitution Instructions: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.
Amino acid sequence: MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
