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Product Description
Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
Biovision | 9240 | Human CellExp 4-1BB Ligand/TNFSF9 Human recombinant DataSheet
Biomolecule/Target: TNFSF9
Synonyms: 4-1BB Ligand, TNFSF9, CD137L
Alternates names: Inhibin beta-1, FRP, FSH-releasing protein
Taglines: A transmembrane cytokine
NCBI Gene ID #: 3624
NCBI Gene Symbol: INHBA
Gene Source: Human
Accession #: P08476
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGEs: 95%
Assay: >95%
Purity: >95%
Assay #2: N/A
Endotoxin Level: < 1 EU/g
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.
Biological activity: The activity is determined by the ability to induce cytoxicity of MPC-11 cells and is typically less than 2 ng/mL.
Results: < 2 ng/mL
Binding Capacity: Measured by its binding ability in a functional ELISA. Immobilized Human 4-1BB, His Tag at 100 ng/mL (100 µl/well), can bind Human 4-1BB Ligand, Fc Tag with a linear of 0.1-2.5 ng/ml and immobilized Human 4-1BB Ligand, Fc Tag at 2 g/ml (100 µl/well), can bind Biotinylated Human 4-1BB, Fc Tag with a linear of 0.5-20 ng/ml.
Unit Definition: N/A
Molecular Weight: 26.2 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.
Amino acid sequence: MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
