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Product Description
4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF. responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF
Biovision | P1306 | Human CellExp 4-1BB / TNFRSF9 Fc Tag Human Recombinant DataSheet
Biomolecule/Target: TNFRSF9
Synonyms: TNFRSF9,4-1BB,CD137,CDw137,ILA
Alternates names: Inhibin beta-1, FRP, FSH-releasing protein
Taglines: A transmembrane cytokine
NCBI Gene ID #: 3624
NCBI Gene Symbol: INHBA
Gene Source: Human
Accession #: P08476
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1 EU/g
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA
Biological activity: The activity is determined by the ability to induce cytoxicity of MPC-11 cells and is typically less than 2 ng/mL.
Results: < 2 ng/mL
Binding Capacity: Immobilized Human 4-1BB, Fc Tag at 0.1 g/mL (100 L/well) can bind Biotinylated Human 4-1BB Ligand, Fc Tag, Avi Tag with a linear range of 0.4-13 ng/mL
Unit Definition: N/A
Molecular Weight: 26.2 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM Glycine, pH 7.5. Normally trehalose is added as protectant before lyophilization.
Reconstitution Instructions: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.
Amino acid sequence: MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS
