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Product Description
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
Biomolecule/Target: TNFRSF17
Synonyms: TNFRSF17, CD269, BCM, BCMA
Alternates names: Proepithelin, PEPI, PC Cell-derived Growth Factor.
Taglines: A member of the TNF receptor superfamily
NCBI Gene ID #: 10090
NCBI Gene Symbol: GRN
Gene Source: Cynomolgus/Rhesus macaque
Accession #: P28798
Recombinant: Yes
Source: HEK293 cells
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1.0 EU per/g
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.
Biological activity: N/A
Results: N/A
Binding Capacity: Immobilized Human BAFF, His Tag at 5 g/mL (100 L/well) can bind Cynomolgus / Rhesus macaque BCMA, Fc Tag with a linear range of 0.05-2 ng/ml
Unit Definition: N/A
Molecular Weight: ~65.0 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in 50 mM Tris, 100 mM Glycine, pH 7.5. Normally trehalose is added as protectant before lyophilization.
Reconstitution Instructions: Reconstitute in distilled water
Amino acid sequence: Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional amino acids.
