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Product Description
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
Biovision | P1074 | Human CellExp BCMA / TNFRSF17 human recombinant DataSheet
Biomolecule/Target: CD269
Synonyms: TNFRSF17, CD269, BCM, BCMA
Alternates names: Proepithelin; PEPI; PC Cell-derived Growth Factor
Taglines: A member of the TNF receptor superfamily
NCBI Gene ID #: 10090
NCBI Gene Symbol: GRN
Gene Source: Human
Accession #: P28798
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: < 1 EU/g
Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.
Biological activity: N/A
Results: N/A
Binding Capacity: Immobilized Human BCMA, His Tag at 5 g/mL (100 L/well) can bind Biotinylated Human BAFF with a linear range of 0.24-3.9 ng/mL.
Unit Definition: N/A
Molecular Weight: ~70.0 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: N/A
Amino acid sequence: Signal peptide and mouse Progranulin (aa 1-589) fused at the C-terminus to a FLAG®-tag.
