Euro
USD
British Pound
NULL
Product Description
CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The full length (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. It has 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy[1] while a high resolution structures of the ectodomain D1 and D2 of CD155 were solved by x-ray crystallography.
Biovision | 7462 | Human CellExp CD155 human recombinant DataSheet
Biomolecule/Target: CD155
Synonyms: PVR, FLJ25946, PVS, CD155, TAGE4, HVED, NECL5, cluster of differentiation 155.
Alternates names: Placenta Growth Factor-2, PGFL
Taglines: Establishes intercellular adherens junctions between epithelial cells
NCBI Gene ID #: 5228
NCBI Gene Symbol: PGF
Gene Source: Human
Accession #: AAB30462
Recombinant: Yes
Source: HEK293 cells
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <1 EU/g by LAL method
Activity (Specifications/test method): N/A
Biological activity: The PLFG-2 is fully biologically active when compared with standards. Recombinant human PIGF-2 can bind to immobilized rh-sFlt-1 (100 ng/well) with linear range at 0.3-10 ng/ml.
Results: 0.3-10 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 18.0 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution Instructions: Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 g/l. The solution can then be diluted into other aqueous buffer
Amino acid sequence: N/A
