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Product Description
Endothelin-Converting Enzyme-1 (ECE-1) is a single-pass type II transmembrane (TM) protein with a short cytoplasmic tail and a large ectodomain. ECE-1 is a zinc protease of the neprilysin (NEP) family, which also includes ECE-2, PEX, XCE, DINE, and Kell, and several NEP-like proteins. It is widely expressed and has several alternatively spliced forms that differ in their TM domain or cytoplasmic tail. All isoforms of ECE-1 are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Endothelin-converting enzyme-1 is involved in the proteolytic processing of Endothelin-1 (EDN1), Endothelin-2 (EDN2), and Endothelin-3 (EDN3) to biologically active peptides. Defects in ECE1 are a cause of Hirschsprung disease, cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction.
Biovision | P1227 | Human CellExp ECE1 Human Recombinant DataSheet
Biomolecule/Target: ECE1
Synonyms: Endothelin-converting enzyme 1, ECE-1
Alternates names: Proliferating cell nuclear antigen, PCNA, Cyclin, MGC8367,
Taglines: Converts big endothelin-1 to endothelin-1
NCBI Gene ID #: 5111
NCBI Gene Symbol: PCNA
Gene Source: Human
Accession #: P12004
Recombinant: Yes
Source: HEK 293 cells
Purity by SDS-PAGEs: 90%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 29.8 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from a 0.2 m filtered solution of PBS, pH7.4
Reconstitution Instructions: N/A
Amino acid sequence: N/A
