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Product Description
GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor -like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Biovision | P1386 | Human CellExp GFR alpha-like Human Recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: GFR alpha like, GFR alpha-like, GFRAL, GRAL
Alternates names: Leukocyte interferon, B cell interferon, Type I interferon, IFNB1, IFB, IFF, IFNB, IFN-b 1b, MGC96956
Taglines: Neuronal brainstem receptor mediating the anorectic funtions of GDF15
NCBI Gene ID #:
NCBI Gene Symbol:
Gene Source: Human
Accession #:
Recombinant: FALSE
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: Less than 1.0 EU per g by the LAL method
Activity (Specifications/test method): N/A
Biological activity: BioVisions Interferon 1b is fully biologically active when compared to standard. The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 32 x 10 IU/ mg.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 18.5 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A
