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Product Description
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (c). The type I receptor contains in addition to the c an IL-4R subunit, whereas the type II receptor contains the IL-13R. The secreted extracellular domain of IL-4R, called sIL-4R, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4R is a 209 amino acid protein which corresponds to the entire extracellular domain of IL- 4R.
Biovision | 7101 | Human CellExp IL-4 R Human Recombinant DataSheet
Biomolecule/Target: IL-4 R
Synonyms: soluble IL-4 receptor alpha, CD124
Alternates names: PBEF, Pre-B cell colony-enhancing factor, Nicotinamide phosphoribosyltransferase NAmPRTase, Nampt, MGC117256, DKFZP666B131, 1110035O14Rik.
Taglines: A receptor for both interleukin 4 and interleukin 13
NCBI Gene ID #: 10135
NCBI Gene Symbol: NAMPT
Gene Source: Human
Accession #: P43490
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).
Activity (Specifications/test method): Determined by its ability to inhibit the IL-4-dependent proliferation of human TF-1 cells. The expected ED50 is 5.0 ng/ml (in the presence of 0.5 ng/ml of hIL-4), corresponding to a specific activity of 2 x 105 units/mg.
Biological activity:
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 55.0 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS pH 7.0.
Reconstitution Instructions: Reconstitute in PBS to the concentration of 0.1-1 mg/ml.
Amino acid sequence: N/A
