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Product Description
IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R and gp130. The IL-6R chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6R. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6R alone. IL-6R is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6R which consists of only the extracellular domain of the IL-6R chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6R is a 37.6 kDa protein consisting of the extracellular domain of the IL-6R chain (339 amino acid residues).
Biovision | 7102 | Human CellExp IL-6 R Human Recombinant DataSheet
Biomolecule/Target: IL-6 R
Synonyms: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126
Alternates names: PBEF, Pre-B cell colony-enhancing factor, Nicotinamide phosphoribosyltransferase NAmPRTase, Nampt, MGC117256, DKFZP666B131, 1110035O14Rik.
Taglines: A type I cytokine receptor
NCBI Gene ID #: 10135
NCBI Gene Symbol: NAMPT
Gene Source: Human
Accession #: P43490
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).
Activity (Specifications/test method): Determined by its ability to intensify the IL-6 induced growth inhibition of mouse M1 cells. The expected ED50 is 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Biological activity:
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 55.0 kDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS pH 7.2.
Reconstitution Instructions: Reconstitute in PBS to the concentration of 0.1-1 mg/ml.
Amino acid sequence: N/A
