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Product Description
Integrins are a family of cell surface transmembrane receptors, each consisting of an and a subunit that bind to extracellular matrix (ECM) proteins and cellular counter receptors and associate with the cytoskeleton. In mammals, 24 different integrins are generated through different combinations of 18 and 8 subunits. A number of human congenital disorders have been associated with defective integrin-mediated adhesion, including the blistering disorder junctional epidermolysis bullosa, the bleeding disorder Glanzmanns thrombastenia , leukocyte adhesion deficiency-I (2 integrins in leukocytes) and leukocyte adhesion deficiency-III, nephrotic syndrome and interstitial lung disease and muscular dystrophy. Integrin alpha-V/beta-5 is a receptor for fibronectin and it recognizes the sequence R-G-D in its ligand.
Biomolecule/Target: ITGB5
Synonyms: ITGB5, integrin subunit beta 5, integrin beta 5
Alternates names: VGR, VGR1, BMP-6, VG-1-related protein
Taglines: Receptor for fibronectin and adenovirus type C
NCBI Gene ID #: 654
NCBI Gene Symbol: BMP6
Gene Source: Human
Accession #: P22004
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: BioVisions recombinant human BMP-6 is biologically active. The ED as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml.
Results: 2-12 µg/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: monomer (15 kDa), dimer (30 kDa)
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A
