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Product Description
Vascular Endothelial Growth Factor (VEGF) plays a key role in tumor angiogenesis in many cancers. The VEGF family consists of seven secretory glycoproteins: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and Placental Growth Factor (PlGF). The binding of VEGF and its receptors leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGFA/VEGF165 is a heparin-binding protein, which exists as a disulfide-linked homodimer. It induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Diseases associated with VEGFA/VEGF165 include microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. It is also related to the integrated Breast Cancer Pathway.
Biovision | 6485 | Human CellExp VEGF 165 Human Recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Vascular endothelial growth factor A, MVCD1, VEGF, VEGF165, VPF, MGC70609, Vascular Endothelial Growth Factor A precursor, Vascular Permeability Factor, VEGFA
Alternates names: Peptidylprolyl isomerase D, PPID, CYPD, CYP-40
Taglines: A signaling protein involved in both vasculogenesis and angiogenesis
NCBI Gene ID #: 5481
NCBI Gene Symbol: PPID
Gene Source: Human
Accession #: Q08752
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Specific activity is > 210 nmoles/min/mg
Results:
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 42.9 kDa
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from 0.22 m filtered solution in PBS pH 7.4
Reconstitution Instructions: N/A
Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGelKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
