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Product Description
Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extraCellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-1 (HRG1-1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-1 (65 amino acid residues).
Biovision | 4711 | Neuregulin/Heregulin-1 NRG-1/HRG-1 human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: NGR beta 1, Heregulin, HRG 1beta, Neuregulin, Neuregulin1 (NRG1-1), Neu differentiation factor, Pro-neuregulin-1, Acetylcholine receptor-inducing activity, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, Neu differentiation factor, Sensory and motor neuron-derived factor
Alternates names: Protein A/G
Taglines: A polypeptide growth factor
NCBI Gene ID #: N/A
NCBI Gene Symbol: N/A
Gene Source: N/A
Accession #: N/A
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: 98%
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 59.7 kDa
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: < 0.5 ng/ml
Reconstitution Instructions: Reconstitution in HO to a concentration of 5 mg/ml gives a clear solution.
Amino acid sequence: N/A
