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Product Description
Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammatio
Biovision | P1402 | OryzaExp Alpha-1 Antitrypsin Human Recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
Alternates names: Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
Taglines: An acute-phase plasma protein
NCBI Gene ID #: 16181
NCBI Gene Symbol: IL-1RA
Gene Source: Human
Accession #: P25085
Recombinant: True
Source: Orzya sativa
Purity by SDS-PAGEs: 98%
Assay: N/A
Purity: N/A
Assay #2: N/A
Endotoxin Level: 1EU/ug
Activity (Specifications/test method): 3~5 mg OsrAAT inhibit 1 mg PPE (pancreatic porcine elastase) with 10.8 units per mg protein.
Biological activity: The mouse IL-1Ra is capable of inhibiting IL-1-alpha activity in helper T cell line D10.G4.1.
Results:
Binding Capacity: N/A
Unit Definition:
Molecular Weight: 43.2 KDa
Concentration: N/A
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile ddHO to a concentration 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Amino acid sequence: The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Cys-Arg-Pro-Ser-Gly.
