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Product Description
TOR proteins is also known as fibrocyte-derived protein (Fdp) and Melanoma inhibitory activity-like (MIAL). Otoraplin is a member of the melanoma-inhibiting activity gene family. Otoraplin is a secreted 16 kDa globular protein that is expressed in the inner ear by periotic mesenchyme and developing and mature fibrocytes. OTOR is highly homologous to MIA/cartilage-derived retinoic acid-sensitive protein (CD-RAP), which is a cartilage-specific protein that is also expressed in malignant melanoma cells. The 111 amino acid mature human otoraplin contains 1 SH3 domain (46 107 amino acids) and a Tyr at position 50 that is reportedly sulfated. Otoraplin takes part in the initiation of periotic mesenchyme chondrogenesis. Otoraplin is secreted through the Golgi apparatus and plays a role in cartilage development and maintenance. A frequent polymorphism in the translation start codon of OTOR can abolish translation and may be associated with forms of deafness. Recombinant human Otoraplin produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids and having a molecular mass of 12.7 kDa.The OTOR is purified by proprietary chromatographic techniques.
Biovision | 4987 | Otoraplin OTOR human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Otoraplin, Fibrocyte-derived protein, Melanoma inhibitory activity-like protein, OTOR, MIAL, FDP, MIAL1, MGC126737, MGC126739,
Alternates names: Jacalin
Taglines: Functions in cartilgae development and maintainence
NCBI Gene ID #: N/A
NCBI Gene Symbol: N/A
Gene Source: N/A
Accession #: Q38720
Recombinant: Yes
Source: Artocarpus heterophyllus (Jackfruit)
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: < 0.1 EU/mg
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity:
Unit Definition: N/A
Molecular Weight: 14.6 kDa ( chain) and 17.1 kDa (full protein)
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Lyophilized without additives
Reconstitution Instructions: Reconstitute in water
Amino acid sequence: MAYSSLLSLS VLALLFSISS ADTRKWFLAN GINQNPIGII EAAVGVSEDL LNLNGMEAKN NKQSGKSQTV IVGPWGAQVS TSSNGKAFDD GAFTGIREIN LSYNKETAIG DFQVIYDLNG SPYVGQNHTS FIKGFTPVKI SLDFPSEYIV DVSGYTGKVS GYVVVRSLTF TNKKTYGPY GVTSGTPFNL PIENGLVVGF KGSIGYWLDY FSMYLSL
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