TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycoly
Source:
E. Coli
Gene name:
TIGAR
Contents:
Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.
Form:
Solid; white powder or thin/invisible film
Purification:
N/A
Storage:
Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.
Application:
Cell Culture
Synonyms:
Fructose-2,6-bisphosphatase TIGAR ;3.1.3.46 ;TP53-induced glycolysis and apoptosis regulator ;TP53-induced glycolysis regulatory phosphatase ;TIGAR ;C12orf5; TP53-induced glycolysis and apoptosis regulator (TIGAR)
Subcellular localization:
Cytoplasm . Nucleus . Mitochondrion . Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017). Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017). Translocated to the nucleus during hypoxia
Tissue specificity:
Expressed in the brain (PubMed:22887998). Expressed in breast tumors (PubMed:21820150). Expressed in glioblastomas (PubMed:22887998). .
BackgroundTIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycoly
SourceE. Coli
Gene nameTIGAR
ContentsProtein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.
FormSolid; white powder or thin/invisible film
PurificationN/A
StorageStore in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.
ApplicationCell Culture
SynonymsFructose-2,6-bisphosphatase TIGAR ;3.1.3.46 ;TP53-induced glycolysis and apoptosis regulator ;TP53-induced glycolysis regulatory phosphatase ;TIGAR ;C12orf5; TP53-induced glycolysis and apoptosis regulator (TIGAR)
Subcellular localizationCytoplasm . Nucleus . Mitochondrion . Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017). Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017). Translocated to the nucleus during hypoxia
Tissue specificityExpressed in the brain (PubMed:22887998). Expressed in breast tumors (PubMed:21820150). Expressed in glioblastomas (PubMed:22887998). .
Uniprot IDQ9NQ88
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