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![Recombinant Human Oncostatin M (209aa) (OSM) Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/671800/929643/logo__42078.1651665136__73189.1651684381.jpg?c=2 "Recombinant Human Oncostatin M (209aa) (OSM) Protein [E. coli]"){kind=logo}
![Recombinant Human Oncostatin M (209aa) (OSM) Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/671800/929643/logo__42078.1651665136__73189.1651684381.jpg?c=2 "Recombinant Human Oncostatin M (209aa) (OSM) Protein [E. coli]"){kind=logo}
Product Description
Recombinant Human Oncostatin M (209aa) (OSM) Protein [E. coli] | 100-352S/100-352 | ReliaTech
Species: Human
Host / biotech: E. coli
Comment: N/A
Label: N/A
Clone / Antibody feature: N/A
Subcategory: Cytokines & Growth Factors
Category: Recombinant Protein
Synonyms: OSM
Isotype: N/A
Application: N/A
Detection Range: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Species Reactivity/Cross reactivity: Mouse, Human
Antigen: N/A
Description: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi’s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein. Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide and generates the mature OSM form. Recombinant human Oncostatin M is a 23.9 kDa protein, containing 209 amino acid residues
Purity Confirmation: > 98% by SDS-PAGE & HPLC analyses
Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
Formulation: lyophilized
Storage Handling Stability: N/A
Reconstituation: N/A
Molecular Weight: 23.6 kDa
Lenght (aa): 209
Protein Sequence: AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRR
NCBI Gene ID: 5008
![Recombinant Human Oncostatin M (209aa) (OSM) Protein [E. coli]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671800/929643/logo__42078.1651665136__73189.1651684381.jpg?c=2 "Recombinant Human Oncostatin M (209aa) (OSM) Protein [E. coli]"){kind=logo}
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![Recombinant Human Oncostatin M (196aa) (OSM) Protein [HEK 293 cells]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/671799/929642/logo__42078.1651665136__96966.1651684380.jpg?c=2 "Recombinant Human Oncostatin M (196aa) (OSM) Protein [HEK 293 cells]"){kind=logo}
