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Product Description
Rat Anti-Mouse VEGFR-2/KDR, Agonistic Antibody | mV1001r-m | ReliaTech
Species: Anti-Mouse
Host / biotech: Rat
Comment: N/A
Label: N/A
Clone / Antibody feature: (#3D09)
Subcategory: Monoclonal Antibody
Category: Antibody
Synonyms: vascular endothelial growth factor receptor-2 ; KDR; FLK1; CD309; VEGF receptor 2; kinase insert domain protein receptor
Isotype: IgG2a
Application: WB, IP, IHC, Flk1 activation
Detection Range: VEGFR-2 activation: This antibody can induce mVEGFR2 phosphorylation in mSENDs at > 1.0 μg/mL.
Species Reactivity/Cross reactivity: Mouse
Antigen: hVEGFR2 N-terminal fragment (N30-200)
Description: VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis. The antibody will bind near the ligand binding site of the receptor and has agonistic activity.
Purity Confirmation: N/A
Endotoxin: N/A
Formulation: lyophilized
Storage Handling Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Reconstituation: Centrifuge vial prior to opening. Reconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.
Molecular Weight: N/A
Lenght (aa): N/A
Protein Sequence: N/A
NCBI Gene ID: 3791
