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Product Description
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Biovision | A1007 | LGR5 Antibody DataSheet
Antibody Target: LGR5
Target Alternative Name: Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, GPR49, GPR67
Tag Line: Polyclonal Antibody to detect LGR5 in Human, mouse and rat samples.
Category: LGR5
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human, Mouse, Rat
Immunogen Sequence: synthetic human LGR5 peptide (Ile685 - Pro720)
Accession #: O75473
Gene ID: 8549
Appearance: Colorless liquid
Form: Liquid
Concentration: N/A
Formulation: 100 µl antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification: Affinity purified rabbit IgG
Application: Western Blot, Immunofluorescent staining, Immunohistochemistry, Flow cytometry
Positive Control: Western blot
Application And Usages: Western Blot 1:1000; Immunofluorescent staining 1:100; Immunohistochemistry 1:25; Flow cytometry 1:25
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: Verified
Immunocytochemistry Verified: Verified
Immunofluorescence Verified: Verified
Immunoprecipitation Verified: Not Verified
FACS Verified:
ELISA Verified: Not Verified
ChIP Verified: Not Verified
Dot Blot Verified: Not Verified
Flow Cytometry Verified: Verified
