Product Description
The research-grade biosimilar is a humanized IgG2, kappa monoclonal antibody that selectively targets P-selectin (SELP). P-selectin is a glycoprotein found on the surface of endothelial cells. It belongs to the family of Selectins and functions as a cell adhesion molecule (CAM). Upon binding to its ligand P-selectin glycoprotein ligand-1 (PSGL-1, SELPLG), SELP controls the flow of white blood cells and how they adhere to the walls of blood vessels during inflammatory and tissue repair conditions. In sickle cell anemia, SELP increases the adhesion of sickle cell red blood cells to blood vessels, thereby restricting blood flow and causing inflammation and pain crises. The monoclonal antibody binds to SELP and prevents its interaction with the ligand and thus restores the normal flow of the blood. The original monoclonal antibody is FDA approved to treat patients with sickle cell disease and sickle cell-associated vaso-occlusive crises
Biovision | A2248 | Anti-SELP (Crizanlizumab), Humanized Antibody DataSheet
Antibody Target: SELP
Target Alternative Name: CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, SELP
Tag Line: The biosimilar is a humanized monoclonal antibody that targets P-Selectin (SELP) and inhibits its interaction with P-selectin glycoprotein ligand-1 (PSGL-1) on neutrophils and monocytes, thereby maintaining the normal flow of blood. The original monoclonal antibody is approved by the FDA to treat sickle cell anemia and sickle cell-associated vaso-occlusive crises
Category: Biosimilars
Host: Recombinant
Isotype: IgG2, kappa
Species Reactivities: Human
Immunogen Sequence: Human P-Selectin
Accession #: DB15271
Gene ID: 6403
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE