Product Description
The research-grade biosimilar is a humanized single-chain Fv (scFv) antibody fragment that targets vascular endothelial growth factor A (VEGF-A). VEGF-A is a pro-angiogenic protein that plays a significant role in the pathogenesis of several diseases such as age-related macular degeneration, cancer, and diabetic retinopathy. Binding of VEGF-A to its receptor activates several downstream proteins such as PI3K, Ras, and MAPK, and promotes proliferation, growth, and migration of endothelial cells. The antibody binds to VEGF-A and prevents binding to its receptors, thereby inhibiting neovascularization, vascular permeability, and proliferation of endothelial cells. The small size of the antibody not only allows it to retain the ability to bind to its target protein, but also provides efficient penetration into the retina and choroid, and faster clearance from the system. The original antibody received approval from the FDA to treat wet age-related macular degeneration
Biovision | A2221 | Anti-VEGF-A (Brolucizumab), Humanized Antibody DataSheet
Antibody Target: VEGFA
Target Alternative Name: ESBA-1008, ESBA1008, RTH-258, RTH258, VPF, VEGF, MVCD1, VEGFA
Tag Line: The biosimilar is a humanized scFv antibody fragment that targets VEGF-A and prevents neovascularization and proliferation of endothelial cells. The original monoclonal antibody is approved to treat wet age-related macular degeneration
Category: Biosimilars
Host: Recombinant
Isotype: scFv-kappa-heavy
Species Reactivities: Human
Immunogen Sequence: Human VEGFA
Accession #: DB14864
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE