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Product Description
Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5, is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.
Biovision | P1427 | Human CellExp™ Complement C5a , Mouse recombinant DataSheet
Biomolecule/Target :
Synonyms: C5a, Complement Component 5a, Hemolytic complement
Alternates names: C5a, Complement Component 5a, Hemolytic complement
Taglines: a potent chemotactic factor for human peripheral blood neutrophils and monocytes
NCBI Gene ID #: 15139
NCBI Gene Symbol: C5
Gene Source: Mouse
Accession #: P06684
Recombinant: True
Source: E.coli
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.9 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized powder
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: AA Asn 679 - Arg 755
Handling: Centrifuge the vial prior to opening.
Usage:
