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Product Description
The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Biovision | P1458 | Human CellExp™ IL-12 R beta 1 / CD212, Fc Tag, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1
Alternates names: IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1
Taglines: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction.
NCBI Gene ID #: 3594
NCBI Gene Symbol: IL12RB1
Gene Source: Human
Accession #: P42701
Recombinant: False
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 83.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: Cys 24 - Glu 540
Handling: Centrifuge the vial prior to opening.
Usage:
