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Product Description
LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse. Recombinant mouse LRIG1, fused to His-tag at Cterminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Biovision | P1557 | LRIG1, Mouse Recombinant DataSheet
Biomolecule/Target :
Synonyms: LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1
Alternates names: LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1
Taglines: Tumor suppressor, negative regulator of the EGF
NCBI Gene ID #: 16206
NCBI Gene Symbol: Lrig1
Gene Source: Mouse
Accession #: P70193
Recombinant: TRUE
Source: Baculovirus
Purity by SDS-PAGE: >90%
Assay: SDS - PAGE
Purity:
Assay #2:
Endotoxin Level: < 1 EU per 1 ug of protein (determined by LAL method)
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 84.8 kDa (His-tag at C terminus)
Concentration: 0.5 mg/ml (determined by Bradford assay)
Appearance: Liquid
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence: 770 aa (aa 35-796)
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
