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Biovision

  • Thiazovivin

    Biovision | Thiazovivin | 1681

    Cell-permeable. Helps in promoting human embryonic stem cell (hESC) survival by > 30-fold. Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells...

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  • TAME Hydrochloride

    Biovision | TAME Hydrochloride | 2050

    A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1...

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  • A-674563

    Biovision | A-674563 | B1761

    A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.A-674563 is a potent,...

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  • MK-5108

    Biovision | MK-5108 | B1344

    MK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nMMK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nMBiovision | B1344 | MK-5108 DataSheetAlternate...

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  • LY2886721

    Biovision | LY2886721 | 2299

    Cell-permeable. A potent and selective β-secretase (BACE-1) inhibitor (IC₅₀ = 20 nM for recombinant hBACE1). Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A...

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  • GSK2578215A

    Biovision | GSK2578215A | 2845

    GSK2578215A is a potent and highly selective leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Shows...

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  • I-BET151

    Biovision | I-BET151 | 2220

    A BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays highefficacy against human and murine MLL-fusion leukemic cell lines, through...

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  • Boc-D-FMK

    Biovision | Boc-D-FMK | 1160

    A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can...

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  • Crenolanib

    Biovision | Crenolanib | 9679

    Crenolanib is a highly selective and potent FLT3 tyrosine kinase inhibitor (TKI) with activity against the internal tandem duplication (FLT3/ITD) mutants and the FLT3/D835 point mutants. Also...

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  • Avasimibe

    Biovision | Avasimibe | 9506

    Avasimibe is an orally bioavailable inhibitor of the acyl coenzyme A: cholesterol acyltransferase (ACAT) (IC₅₀ = 60 nM). Avasimibe also inhibits major drug metabolizing enzymes such as CYP2C9 (IC₅₀ =...

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  • Zanamivir

    Biovision | Zanamivir | B1900

    Zanamivir is a potent and selective inhibitor of influenza A and B virus neuraminidases with IC₅₀ values of 0.95 nM and 2.7 nM, respectively. It interacts with a group of amino acids in the active...

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  • ONX-0914

    Biovision | ONX-0914 | 2555

    A potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome. It selectively inhibits low–molecular mass polypeptide-7 (LMP7, encoded by Psmb8), the...

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  • T0070907

    Biovision | T0070907 | 2095

    T0070907 is a potent and selective antagonist of the human PPARγ (IC50 = 1 nM). T0070907 suppresses breast cancer cell proliferation and motility via both PPARγ-dependent and –independent mechanisms...

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  • CHIR-98014

    Biovision | CHIR-98014 | 2595

    Cell-permeable. CHIR-98014 is a potent, selective and ATP-competitive inhibitor of GSK3α and GSK3β (IC₅₀ = 0.65 and 0.58 nM, respectively). In addition, CHIR-98014 displays 500 to greater than...

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  • Golvatinib

    Biovision | Golvatinib | 2655

    Golvatinib ( E7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with...

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  • Cobimetinib

    Biovision | Cobimetinib | B1689

    Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of...

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  • ADX-47273

    Biovision | ADX-47273 | 9562

    ADX-47273 is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC₅₀ = 0.17 μm, with no effect on other mGluR subtypes. ADX-47273 elevates extracellular signal-regulated...

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  • DAPT

    Biovision | DAPT | 1855

    Cell permeable. A potent inhibitor of γ-secretase (IC₅₀ = 115 nM for total β-amyloid, IC₅₀ = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and...

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  • MRT67307

    Biovision | MRT67307 | B1604

    MRT67307 is a dual inhibitor of the IKKe and TBK-1MRT67307 is a dual inhibitor of the IKKe and TBK-1Biovision | B1604 | MRT67307 DataSheetAlternate Name/Synonyms:...

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  • Ivacaftor

    Biovision | Ivacaftor | 9582

    Ivacaftor (VX-770) is a potent, cell-permeable small molecule potentiator of cystic fibrosis transmembrane conductance regulator (CFTR). It increases the forskolin-induced CFTR-mediated epithelial...

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  • RepSox

    Biovision | RepSox | 1894

    Cell-permeable. A TGF-β type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC₅₀ = 4 nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used...

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  • Laquinimod

    Biovision | Laquinimod | 2332

    A potent immunomodulator. Also displays anti-inflammatory properties.Laquinimod is a potent immunomodulator. Also displays anti-inflammatory properties.Biovision | 2332 | Laquinimod...

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  • Torin 1

    Biovision | Torin 1 | 2273

    A potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM)...

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  • Torin 2

    Biovision | Torin 2 | 2274

    A potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively)...

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  • Quizartinib

    Biovision | Quizartinib | 2008

    Cell-permeable. A second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular...

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  • Spautin-1

    Biovision | Spautin-1 | 2037

    Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and...

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  • Pimozide

    Biovision | Pimozide | 1887

    Cell-permeable. An antipsychotic drug and D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7 receptor. A Stat5 inhibitor; decreases Stat5 tyrosine phosphorylation, but does...

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  • PRT-060318

    Biovision | PRT-060318 | B1911

    PR-060318 is a potent and selective Syk inhibtor. It prevents both HIT (Heparin-induced thrombocytopenia) immune complex-induced thrombocytopenia and thrombosis in vivo.PR-060318 is a potent and...

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  • Nampt-IN-1

    Biovision | Nampt-IN-1 | B1171

    Nampt-IN-1 is a potent and selective NAMPT (Nicotinamide phosphoribosyltransferase) inhibitor. Displays potent anticancer properties. NAMPT is found to be upregulated in various cancer cells and...

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  • SGI-7079

    Biovision | SGI-7079 | B1202

    SGI-7079 is a potent and selective Axl inhibitor with potential anticancer activity. SGI-7079 significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC₅₀ of 0.43 or 0.16 μM,...

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  • AMG319

    Biovision | AMG319 | B1663

    AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, also inhibits PI3Kγ with IC50 of 850 nM.AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, also inhibits PI3Kγ...

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  • GNE-3511

    Biovision | GNE-3511 | B1341

    GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.Biovision | B1341 | GNE-3511 DataSheetAlternate...

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  • OAC2

    Biovision | OAC2 | B1080

    OAC2 is an Oct4-activating compound that activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC2 (1 μM) enhances reprogramming efficiency by...

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  • IWP-4

    Biovision | IWP-4 | 2650

    IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC₅₀ = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for...

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  • BQU57

    Biovision | BQU57 | 9576

    BQU57 is a GTPase Ral inhibitor. Displays selectivity for Ral relative to the GTPases Ras and RhoA and inhibits tumor xenograft growth to a similar extent to the depletion of Ral using RNA...

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  • RBC8

    Biovision | RBC8 | B1136

    RBC8 is cell-permeable small molecule that inhibits the binding of Ras-like GTPases A and B ( RalA and RalB GTPase ) to RaLBP1 and shown to suppress growth of xenograft tumors in mice. It reduces the...

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  • Nazartinib

    Biovision | Nazartinib | B2288

    Nazartinib is a potent, irreversible, third-generation, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. It covalently binds to and inhibits...

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  • AZD9496

    Biovision | AZD9496 | B1652

    AZD9496 is a potent and orally bioavailable selective estrogen receptor down regulator (Ki=0.7 nM) and antagonist.AZD9496 is a potent and orally bioavailable selective estrogen receptor down...

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  • PT-2385

    Biovision | PT-2385 | B1920

    PT-2385 is a potent ad selective inhibitor of hypoxia inducible factor (HIF-2α) with potential antineoplastic activity. PT-2385 selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Very...

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  • JNJ-42041935

    Biovision | JNJ-42041935 | B1072

    JNJ-42041935 is a HIF-PHD (Hypoxia-inducible factor- prolyl hydroxylase) inhibitor. JNJ-42041935 is a selective, 2-OG (2-oxoglutarate) competitive, and reversible inhibitor of PHD enzymes (pKis = 7...

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  • BLU9931

    Biovision | BLU9931 | 9639

    BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4. It potently inhibits FGFR4 activity (IC₅₀ = 3 nM), but only weakly inhibits FGFR1 (IC₅₀ = 591 nM), FGFR2 (IC₅₀ = 493 nM), and...

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  • EHop-016

    Biovision | EHop-016 | 9595

    EHop-016 is an analog of NSC-23766 (Cat. No. 1941) that acts as a potent inhibitor of Rac GTPase (IC₅₀ = 1.1 µM for Rac1). The IC₅₀ of 1.1 μM for Rac inhibition by EHop-016 is ∼100-fold lower than...

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  • Optovin

    Biovision | Optovin | 9594

    Optovin is a reversible photoactive TRPA1 activator. It specifically activates TRPA1 (EC₅₀ = 2 μM) but not TRPV1 or TRPM8. Optovin activates human TRPA1 via structure-dependent photochemical...

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  • STF-118804

    Biovision | STF-118804 | 9552

    STF-118804 is a potent and highly specific inhibitor of Nampt (nicotinamide phosphoribosyl transferase) (IC₅₀s = 3-6 nM) that prevents NAD⁺ synthesis from nicotinamide. It inhibits the viability of...

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  • FIPI

    Biovision | FIPI | 9593

    FIPI is a potent phospholipase D (PLD) inhibitor. FIPI inhibits both PLD1 (IC₅₀ = 25 nM) and PLD2 (IC₅₀ = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and...

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  • Etrasimod

    Biovision | Etrasimod | B2319

    A potent and selective sphingosine-1-phosphate-1 (S1P1) receptor antagonist (IC₅₀ =1.88 nM in CHO cells).Etrasimod (APD334) is a potent and selective sphingosine-1-phosphate-1 (S1P1) receptor...

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  • L-779450

    Biovision | L-779450 | B1709

    L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.L-779450 is a potent, ATP-competitive...

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  • Cyantraniliprole

    Biovision | Cyantraniliprole | B1648

    Cyantraniliprole (HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.Cyantraniliprole...

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  • IC261

    Biovision | IC261 | 9669

    IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = ~1 µM for CK1δ and CK1ɛ and 16 µM for CK1α). It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn...

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  • BLZ945

    Biovision | BLZ945 | B1651

    BLZ945 is a brain-penetrant CSF-1R kinase inhibitor. The biochemical IC50 for CSF-1R is 1 nM, which is >3200-fold higher than its affinity for other kinases.BLZ945 is a brain-penetrant CSF-1R kinase...

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  • GNE-317

    Biovision | GNE-317 | B1716

    GNE-317 is a potent and selective PI3K inhibitor with potential anticancer activity.GNE-317 is a potent and selective PI3K inhibitor with potential anticancer activity.Biovision | B1716 | GNE-317...

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