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Biovision | Cyproheptadine Hydrochloride Sesquihydrate | B3253

Cyproheptadine hydrochloride sesquihydrate is an antagonist of serotonin and histamine. It induces preventive effect against the development of pergolide-induced valvulopathy in a rat model. Also...

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Biovision | A-196 | B3252

A-196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively). Displays 100-fold selectivity over other histone methyltransferases and non-epigenetic targets...

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Biovision | BCI-121 | B3251

BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level, downregulates known SMYD3 target genes transcription, and selectively affects...

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Biovision | CM-272 | B3250

CM-272 is a potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM,...

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Biovision | Bobcat339 (free base) | B3249

Bobcat339 is a potent cytosine-based TET (ten-eleven translocation methylcytosine dioxygenase) enzyme inhibitor with IC50 of 33 µM (TET1) and 73 µM (TET2). Bobcat339 does not inhibit the DNA...

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Biovision | CIL56 | B3248

CIL56 is a small molecule that acts as a selective ferroptosis inducer through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated,...

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Biovision | TED-347 | B3247

TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically...

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Biovision | GW-806742X | B3246

GW-806742X is a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, as well as a human and murine necroptosis inhibitor. GW806742X binds the MLKL pseudokinase domain with a Kd value of...

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Biovision | Bazedoxifene acetate | B3245

Bazedoxifene acetate (TSE-424 acetate) is a nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene acetate can be used...

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Biovision | THPP | B3244

THPP is a versatile, water-soluble and air-stable reducing agent, useful for the rapid, irreversible reductive cleavage of disulfide bonds in both aqueous and buffered aqueous-organic media. THPP...

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Biovision | DTBA | B3242

DTBA is a novel biological reducing reagent with enhanced properties over other commonly used reagents. DTBA has been shown to reduce small molecule disulfides 3-5-fold faster than DTT (Cat. No...

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Biovision | Violacein | B3241

Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, displays multiple biological activities, including strong inhibition of Gram-positive pathogens. It...

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Biovision | Fangchinoline | B3240

Fangchinoline is a bisbenzylisoquinoline alkaloid that has been shown to elicit anti-cancer effects in prostate and breast cancer cell lines via inducing G1 cell cycle arrest. It has also been shown...

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Biovision | Hesperetin | B3239

Hesperetin is a naturally occurring flavonoid that displays diverse biological activities. It inhibits neuroinflammation on microglia by suppressing inflammatory cytokines and MAPK pathways. It...

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Biovision | Pristimerin | B3238

Pristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Pristimerin inhibits inflammation and tumor angiogenesis and significantly reduces vessel density in...

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Biovision | Lycorine hydrochloride | B3237

Lycorine is a naturally occurring alkaloid found in plants in the Amaryllidaceae family; it displays antifungal, anti-parasitic, and anticancer activities. Acts as a selective inhibitor of peptidyl...

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Biovision | Matrine | B3236

Matrine is a biologically active alkaloid isolated from the root of the saphoro plant. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages...

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Biovision | Azoramide | B3235

Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER...

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Biovision | Amiselimod Hydrochloride | B3234

Amiselimod (MT1303), is a potent and selective immunosuppressant and sphingosine 1 phosphate 1 (S1P1) receptor modulator. Amiselimod may be potentially useful for treatment of multiple sclerosis,...

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Biovision | Ranolazine hydrochloride | B3233

Ranolazine blocks the late Na + current and prevents the rise of cytosolic calcium. It decreases myocardial wall tension and improves coronary blood flow. Ranolazine is effective in atrial...

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Biovision | Vortioxetine Hydrobromide | B3232

Vortioxetine hydrobromide is a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively...

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Biovision | Candesartan | B3231

Candesartan is an oral angiotensin II receptor blocker (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). It is available as a pro-drug, candesartan...

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Biovision | CPUY192018 | B3230

CPUY192018 is a potent inhibitor of the Keap1-Nrf2 PPI protein-protein interaction. CPUY192018 displays cytoprotective effects by enhancing the Nrf2-ARE regulated antioxidant system and diminishes...

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Biovision | MYK-461 | B3229

MYK-461 is an orally active inhibitor of cardiac myosin ATPase (IC50 = 0.3 µM in purified bovine myosin S1). It displays selectivity for cardiac myosin over skeletal myosin (IC50 = 4.7 µM) and does...

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Biovision | Malformin A1 | B3228

Malformin A is a cyclopentapeptide fungal metabolite that displays diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits...

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Biovision | Macrosphelide A | B3227

Macrosphelide A is a macrolide antibiotic. It inhibits adhesion of HL-60 human leukemia cells to human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner. It inhibits the...

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Biovision | Harzianum A | B3226

Harzianum A is a trichothecene fungal metabolite isolated from T. harzianum. It is cytotoxic to HeLa, MCF-7, and HT-1080 cells (IC50s = 5.07, 10.13, and 0.65 μg/ml, respectively) and displays...

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Biovision | Funalenone | B3225

Funalenone, a phenalene compound isolated from mycelium of Aspergillus niger FO-5904, acts as an inhibitor of type I collagenase (MMP-1). Funalenone inhibits 50% of type I collagenase activity at a...

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Biovision | Boromycin | B3224

Boromycin is a boron-containing macrolide antibiotic that displays antibacterial, and antiprotozoal properties. Boromycin (3.4 nM) reverses bleomycin-induced cell cycle arrest at the G2 phase in...

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Biovision | Ascofuranone | B3223

Ascofuranone, a compound isolated from the phytopathogenic fungus, Ascochyta visiae, acts as a potent inhibitor of trypanosome alternative oxidase (TAO). (TAO) is the terminal oxidase of the...

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Biovision | 4-Aminobenzamidine dihydrochloride | B3222

4-Aminobenzamidine dihydrochloride is a synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. It is a useful ligand in affinity chromatography for...

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Biovision | Dipyridamole | B3221

Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC50 = 574 nM) that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates...

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Biovision | TG-101209 | B3220

TG101209 is a potent and selective inhibitor of Janus Kinase 2 (JAK2) (IC50 = 6 nM). It displays 28-fold selectivity over JAK3 (IC50 = 169 nM). TG101209 induces dose- and time-dependent cytotoxicity...

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Biovision | ARRY-380 analog | B3219

ARRY-380 analog is an inhibitor of EGFR (ErbB1).ARRY-380 analog is an inhibitor of EGFR (ErbB1).Biovision | B3219 | ARRY-380 analog DataSheetAlternate Name/Synonyms:...

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Biovision | SB1317 (TG-02) | B3218

SB1317 is a potent inhibitor of CDK2, JAK2, and FLT3 with IC50 of 13, 73, and 56 nM, respectively. SB1317 may be useful for the treatment of cancer that crosses the blood brain barrier and acts by...

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Biovision | RO-5006036 | B3217

RO-5006036 (DGAT1-IN-3) also known as DGAT1-IN-3, is a potent, selective and orally bioavailable inhibitor of DGAT-1 (Diacylglycerol O-acyltransferase 1).RO-5006036 (DGAT1-IN-3) also known as...

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Biovision | SR-717 Lithium | B3216

SR-717 is a non-nucleotide STING (stimulator of interferon (IFN) genes) agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a...

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Biovision | SB-743921 Hydrochloride | B3215

SB-743921 hydrochloride is potent kinesin spindle protein (KSP) inhibitor (Ki = 0.1 nM). Displays almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4, and CENP-E. Induces cell mitotic arrest...

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Biovision | A-803467 | B3214

A-803467 is a selctive a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM) and the generation of spontaneous and electrically evoked action potentials in...

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Biovision | LY-2409881 | B3213

LY-2409881 is a potent and selective inhibitor of IκB kinase β (IKK2; IC50 = 30 nM). It inhibits IKK1 and other common kinases only at ≥10-fold higher concentrations. LY2-409881 inhibits...

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Biovision | MK-8998 | B3212

MK-8998 is a potent and selective antagonist of T-type calcium channel. Could be potentially useful for the treatment of schizophrenia.MK-8998 is a potent and selective antagonist of T-type calcium...

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Biovision | cFMS Receptor Inhibitor II | B3211

cFMS Receptor Inhibitor II (BUN-60856) is a potent cell-permeable and potent CSF1R (Colony stimulating factor 1 receptor) kinase inhibitor (IC50 = 80 nM). It potently inhibits the cFMS-dependent...

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Biovision | IMD-0354 | B3210

IMD-0354 is a selective IKKβ inhibitor that blocks IκBα phosphorylation in NF-κB pathway. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM. It has been used to study...

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Biovision | Benfotiamine | B3209

Benfotiamine is an amphiphilic S-acyl thiamine derivative. It is a lipid-soluble vitamin. Benfotiamine contains a thiazole ring. It helps in the prevention of diabetic complications such as,...

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Biovision | Icatibant Acetate | B3208

Icatibant acetate is a potent and specific synthetic peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively. It inhibits bradykinin-induced contractions...

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Biovision | Loxoprofen Sodium | B3207

Loxoprofen sodium is a non-steroidal anti-inflammatory drug (NSAD) with analgesic and anti-pyretic properties. It acts as a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and...

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Biovision | Acebilustat | B3206

Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, that is used as an antiinflammatory drug in development for the treatment of CF and other diseases. Leukotriene A4 hydrolase (LTA4H)...

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Biovision | Granisetron Hydrochloride | B3205

Granisetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 3.9 nM) with antiemetic activity. It displays selectivity for 5-HT3 over 5-HT4 receptors (Ki = >1,000 nM)...

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Biovision | Pemigatinib | B3204

Pemigatinib is a potent and selective inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Pemigatinib binds to and...

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Biovision | Dithranol | B3203

Dithranol is a leukotriene biosynthesis inhibitor. It inhibits LTB4 ω-oxidation and disrupts mitochondria function. Dithranol is highly effective in the treatment of psoriasis. The drug inhibits...

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Biovision | DFHO | B3201

Mimic of red fluorescent protein (RFP) fluorophore for imaging RNA in living cells. Upon binding to the Corn™ aptamer, DFHO is converted to a highly fluorescent state that can be detected at the...

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Biovision | 5-Fluorouridine | B3149

5-Fluorouridine is a ribonucleotide metabolite of 5-Fluorouracil. It is cytotoxic and inhibits rRNA synthesis in human colon carcinoma cells. It exhibits cytotoxic effect on lymphoma cells with an...

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