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Biovision

  • RA-9

    Biovision | RA-9 | B3358

    Biovision | RA-9 | B3358Description: RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor that displays favorable toxicity profile and anticancer activity...

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  • AS-1517499

    Biovision | AS-1517499 | B3357

    Biovision | AS-1517499 | B3357Description: AS-1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor (IC50 = 21 nM). It inhibits IL-4-induced Th2 differentiation (IC50 = 2.3 nM), but...

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  • S107 free base

    Biovision | S107 free base | B3354

    Biovision | S107 free base | B3354Description: S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. The intracellular Ca2+ leak was...

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  • PPQ-102

    Biovision | PPQ-102 | B3353

    Biovision | PPQ-102 | B3353Description: PPQ -102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). PPQ-102 displays nephroprotective and anti-fibrotic activities,...

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  • XL-147

    Biovision | XL-147 | B3352

    Biovision | XL-147 | B3352Description: XL-147 is a potent and reversible Class 1 PI3-kinase family inhibitor with potential antineoplastic activity. Inactivation of PI3K has been shown to inhibit...

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  • AZD-9468

    Biovision | AZD-9468 | B3351

    Biovision | AZD-9468 | B3351Description: AZD-9468 (CXD101) is a potent histone deacetylase (HDAC) inhibitor with potential antineoplastic activity.Alternate Name/Synonyms:...

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  • Tangeretin

    Biovision | Tangeretin | B3350

    Biovision | Tangeretin | B3350Description: Tangeretin is a methoxyflavone compound isolated from citrus fruits that demonstrates antiproliferative and antioxidant effects. It inhibits signaling in...

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  • HLY78

    Biovision | HLY78 | B3349

    Biovision | HLY78 | B3349Description: HLY78 is a positive modulator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote...

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  • Resatorvid

    Biovision | Resatorvid | B3347

    Biovision | Resatorvid | B3347Description: Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages...

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  • PSN -375963

    Biovision | PSN -375963 | B3346

    Biovision | PSN -375963 | B3346Description: PSN-375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. GPR119 that shows similar potency to oleoyl...

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  • CAY-10698

    Biovision | CAY-10698 | B3345

    Biovision | CAY-10698 | B3345Description: CCAY-10698 is an inhibitor of 12-LO (12-lipoxygenase) with an IC50 value of 5.1 µM. It displays weaker potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50,...

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  • 8-Prenylnarinegin

    Biovision | 8-Prenylnarinegin | B3344

    Biovision | 8-Prenylnarinegin | B3344Description: 8-Prenylnaringenin (8-PN) is a non-steroidal phytoestrogen from Hops that mimicks endogenous estrogens via estrogen receptor binding. Inhibits both...

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  • AS-1842856

    Biovision | AS-1842856 | B3343

    Biovision | AS-1842856 | B3343Description: AS-1842856 is a potent and selective Foxo1 (forkhead box class O transcription factor 1) inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and...

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  • AH10639 phosphate

    Biovision | AH10639 phosphate | B3342

    Biovision | AH10639 phosphate | B3342Description: AH10639 phosphate is a novel inhibitor of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. AH10639 is significantly more potent...

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  • Puerarin

    Biovision | Puerarin | B3374

    Biovision | Puerarin | B3374Description: Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) It has been widely used in the treatment of cardiovascular...

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  • PKF118-310

    Biovision | PKF118-310 | B3373

    Biovision | PKF118-310 | B3373Description: PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. It disrupts binding of β-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0...

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  • Baicalin

    Biovision | Baicalin | B3372

    Biovision | Baicalin | B3372Description: Baicalin is a biologically active flavonoid compound that displays anti-inflammatory and anti-oxidant activity. Baicalin inhibits HIV-1 replication by...

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  • AUDA

    Biovision | AUDA | B3371

    Biovision | AUDA | B3371Description: AUDA is an inhibitor of soluble epoxide hydrolase (sEH) (displaying IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively. Produces a...

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  • Albiflorin

    Biovision | Albiflorin | B3370

    Biovision | Albiflorin | B3370Description: Albiflorin, a major constituent isolated from Peony roots, is a monoterpene glycoside with neuroprotective effects. It acts as a novel 5-HT and NE...

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  • Dexrazoxane

    Biovision | Dexrazoxane | B3369

    Biovision | Dexrazoxane | B3369Description: Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. Dexrazoxane could chelate iron to decrease the generation of ROS, thus...

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  • ARV-771

    Biovision | ARV-771 | B3368

    Biovision | ARV-771 | B3368Description: ARV-771 is a potent BET bromodomain PROTAC® degrader with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2),...

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  • A-317491

    Biovision | A-317491 | B3367

    Biovision | A-317491 | B3367Description: A-317491 is a selective non-nucleotide antagonist of P2X3 and P2X2/3 receptor activation. A-317491 potently blocks recombinant human and rat P2X3 and P2X2/3...

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  • Ch 55

    Biovision | Ch 55 | B3366

    Biovision | Ch 55 | B3366Description: Ch 55 is a synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Ch 55...

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  • Risedronate sodium

    Biovision | Risedronate sodium | B3365

    Biovision | Risedronate sodium | B3365Description: Risedronate (risedronic acid), is an orally administered pyridinyl bisphosphonate that inhibits osteoclast-mediated resorption of bone and modulates...

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  • Isorhamnetin

    Biovision | Isorhamnetin | B3364

    Biovision | Isorhamnetin | B3364Description: Isorhamnetin is a natural flavonol aglycone that displays antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM). It also competitively...

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  • Medicarpin

    Biovision | Medicarpin | B3363

    Biovision | Medicarpin | B3363Description: Medicarpin is a pterocarpan class of naturally occurring benzopyran furanobenzene compound. In calvarial osteoblasts, medicarpin blocks nuclear factor...

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  • SC-75741

    Biovision | SC-75741 | B3361

    Biovision | SC-75741 | B3361Description: SC-75741 is a potent NF-κB inhibitor (EC50 = 200 nM) that efficiently blocks influenza virus propagation. The mechanism of SC-75741 action involves impaired...

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  • TCS-1102

    Biovision | TCS-1102 | B3360

    Biovision | TCS-1102 | B3360Description: TCS-1102 is a potent, brain-permeable dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively. It is a poor...

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  • YM-254890

    Biovision | YM-254890 | B3393

    Biovision | YM-254890 | B3393Description: YM-254890 is a cyclic depsipeptide that acts as a Gα-protein inhibitor. It potently inhibits Gq/11 heterotrimeric G protein signaling. Inhibits...

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  • CMPD101

    Biovision | CMPD101 | B3392

    Biovision | CMPD101 | B3392Description: CMPD101 is a potent, selective and cell-permeable GRK2/3 inhibitor (IC50 values are 32 and 54 nM for GRK3 and GRK2, respectively). CMPD101 displays selectivity...

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  • Gallein

    Biovision | Gallein | B3391

    Biovision | Gallein | B3391Description: Gallein is an inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated...

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  • Tedizolid

    Biovision | Tedizolid | B3389

    Biovision | Tedizolid | B3389Description: Tedizolid is an oxazolidinone-class antibiotic. It exerts its bacteriostatic microbial activity through inhibition of protein synthesis by binding to the 50S...

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  • MRX-2843

    Biovision | MRX-2843 | B3388

    Biovision | MRX-2843 | B3388Description: MRX-2843 (UNC2371) is a potent, ATP-competitive dual MERTK and FLT3 tyrosine kinases inhibitor (TKI) with enzymatic IC50s of 1.3 nM for MERTK and 0.64 nM for...

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  • YKL-05-099

    Biovision | YKL-05-099 | B3387

    Biovision | YKL-05-099 | B3387Description: YKL-05-099 is an inhibitor of the salt-inducible kinase (SIK1 and SIK3; IC50s: 10 and 30 nM, respectively). It displays less potency towards SIK2 (IC50 = 40...

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  • Telotristat

    Biovision | Telotristat | B3386

    Biovision | Telotristat | B3386Description: Telotristat is an oral, small molecule inhibitor of tryptophan hydroxylase 1 (TPH1) IC50 = 16 nM) that is used in the treatment of symptoms of carcinoid...

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  • Isorhapontigenin

    Biovision | Isorhapontigenin | B3385

    Biovision | Isorhapontigenin | B3385Description: Isorhapontigenin is a polyphenolic compound found in Chinese herbs and grapes that displays anti-inflammatory effects. Isorhapontigenin induces...

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  • VAL-083

    Biovision | VAL-083 | B3384

    Biovision | VAL-083 | B3384Description: VAL-083 is a bifunctional alkylating agent with antitumor activity. Upon administration, VAL-083 crosses the blood brain barrier (BBB) and appears to be...

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  • Conophylline

    Biovision | Conophylline | B3383

    Biovision | Conophylline | B3383 Description: Conophylline is a naturally occurring plant-based vinca alkaloid that acts as a novel differentiation inducer for pancreatic β cells; can increase...

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  • Sulindac

    Biovision | Sulindac | B3382

    Biovision | Sulindac | B3382Description: Sulindac is non-steroidal anti-inflammatory drug (NSAID) and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and...

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  • BNC-105

    Biovision | BNC-105 | B3381

    Biovision | BNC-105 | B3381Description: BNC-105 is a tubulin polymerization inhibitor and vascular disrupting agent (VDA) with potent antiproliferative and tumor vascular disrupting properties...

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  • Polydatin

    Biovision | Polydatin | B3380

    Biovision | Polydatin | B3380Description: Polydatin is a monocrystalline compound isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae). It displays antioxidant and...

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  • Emavusertib

    Biovision | Emavusertib | B3378

    Biovision | Emavusertib | B3378Description: Emavusertib is an orally bioavailable, reversible inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4), with potential antineoplastic,...

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  • Etalocib

    Biovision | Etalocib | B3376

    Biovision | Etalocib | B3376Description: Etalocib (LY293111) is a potent and selective inhibitor of the lipoxygenase pathway either directly through 5'-lipoxygenase or via antagonism of the...

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  • MK-2461

    Biovision | MK-2461 | B3359

    Biovision | MK-2461 | B3359Description: MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met. MK-2461 inhibits in vitro phosphorylation of a peptide substrate recognized by...

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