Product Description
Anti- VWF, VWFpp Antibody | FNab09466 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Von Willebrand factor (vWF) is a large multimeric glycoprotein that is crucial to the hemostasis process. It supports platelet adhesion and carries factor VIII (FVIII) . Deficiency of vWF results in von Willebrand disease (vWD), a common inherited bleeding disorder. The pre-pro-vWF is comprised of 2, 813 amino acids (aa) which encompass a 22-aa signal peptide, a 741-aa large propeptide (vWF propeptide, vWFpp, also called von Willebrand antigen II) and 2, 050 aa making up the mature vWF. The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. This antibody raised against the N-terminal region of pre-pro-vWF recognizes von Willebrand antigen 2 (75-83 kDa) and pro-vWF (309-320 kDa) .
Immunogen: von Willebrand factor
synonyms: F8VWF, von Willebrand antigen II, von Willebrand factor, VWD, VWF
Molecular weight (observed) : 75 kDa, 309 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IHC, WB, IF
Recomended Dillution : WB: 1:200-1:2000; IHC: 1:100-1:400
Research Area: Immunology, Cardiovascular