Product Description
The research-grade biosimilar is a humanized monoclonal antibody fragment that targets the von Willebrand factor (VWF). The original monoclonal antibody is a bivalent single-variable-domain linked by a three alanine linker. The antibody was approved for the treatment of acquired thrombotic thrombocytopenic purpura (TTP). Acquired TTP occurs due to the production of inhibitory autoantibodies against ADAMTS13. This leads to decreased ADAMTS13 activity that prevents cleavage of the von Willebrand factor. As a result, ultra-large von Willebrand factor multimers form that results in binding of the A1 domains of the VWF multimers to the platelets via glycoprotein Ib? and cause platelet aggregation. Aggregation of platelets leads to the formation of microthrombi, which causes ischemia of the tissues and dysfunction of multiple organs, ultimately leading to cognitive deficits, arterial hypertension, and early death. The original monoclonal antibody binds to the A1 domains of the VWF and inhibits the association with platelets thus preventing platelet aggregation and microthrombi formation
Biovision | A2263 | Anti-VWF (Caplacizumab), Humanized Antibody DataSheet
Antibody Target: VWF
Target Alternative Name: VWD, F8VWF, VWF, von Willebrand factor, Coagulation Factor VIII VWF
Tag Line: The biosimilar is a humanized monoclonal antibody that targets von Willebrand factor (VWF)
Category: Biosimilars
Host: Recombinant
Isotype: VH-VH
Species Reactivities: Human
Immunogen Sequence: Human VWF
Accession #: DB06081
Gene ID: 7450
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE