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Product Description
A Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
Aftin-4 is a Roscovitine-related purine derivative that selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable.
Biovision | 2574 | Aftin-4 DataSheet
Alternate Name/Synonyms: N6-Methyl-(R)-roscovitine; Amyloid-β Forty-Two Inducer 4
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 866893-90-5
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₈N₆O
Molecular Weight: 368.48
Cell-Permeable?: Yes
Purity: ≥98% by NMR
Solubilities: DMSO or EtOH
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An amyloid-β42 Inducer
MDL Number: N/A
PubChem CID: N/A
SMILES: CC[C@H](CO)NC1=NC(N(C)CC2=CC=CC=C2)=C3C(N(C(C)C)C=N3)=N1
InChi: InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1
InChi Key: YPYWONAECUVKHY-MRXNPFEDSA-N
