Product Description
HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human foreskin fibroblast (HFS) and transformed (LNCaP, human prostate adenocarcinoma, A549 lung adenocarcinoma, and U87 glioblastoma) cells in a concentration-dependent manner at 8 μM, 16 μM, or 32 μM, but does not induce cell death. HPOB causes accumulation of acetylated α-tubulin in these cells. HPOB enhances cell death induced by the anticancer drugs etoposide, doxorubicin and SAHA.
HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human foreskin fibroblast (HFS) and transformed (LNCaP, human prostate adenocarcinoma, A549 lung adenocarcinoma, and U87 glioblastoma) cells in a concentration-dependent manner at 8 μM, 16 μM, or 32 μM, but does not induce cell death. HPOB causes accumulation of acetylated α-tubulin in these cells. HPOB enhances cell death induced by the anticancer drugs etoposide, doxorubicin and SAHA.
Biovision | B2832 | HPOB DataSheet
Alternate Name/Synonyms: N-hydroxy-4-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]benzamide; 4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-Oxidanylidene-Ethyl]-~{n}-Oxidanyl-Benzamide; 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenylbenzeneacetamide
Appearance: Crystalline solid
Formulation:
CAS Number: 1429651-50-2
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₁₇H₁₈N₂O₄
Molecular Weight: 314.34
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~10 mg/ml in DMF in 0, ~15 mg/ml in in Ethanol, ~20 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent inhibitor of HDAC6
MDL Number: MFCD27952937
PubChem CID: 71532921
SMILES: C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO
InChi: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)
InChi Key: RFAZNTABYJYOAR-UHFFFAOYSA-N