Product Description
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with mTOR inhibition in tumor cells.
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with mTOR inhibition in tumor cells.
Biovision | B1286 | SAR-405 DataSheet
Alternate Name/Synonyms: (8S)-9-[(5-Chloropyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3h-pyrimido[1,2-A]pyrimidin-4-one
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1523406-39-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₂₁ClFN₅O₂
Molecular Weight: 443.85
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy a
MDL Number: N/A
PubChem CID: 72709209
SMILES: CC1COCCN1C2=CC(=O)N3CCC(N(C3=N2)CC4=CC(=CN=C4)Cl)C(F)(F)F
InChi: InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1
InChi Key: SPDQRCUBFSRAFI-DOMZBBRYSA-N