Product Description
The research-grade biosimilar antibody is a humanized monoclonal antibody fragment that specifically neutralizes the anti-coagulatory effect of dabigatran. Dabigatran is a non-peptidic inhibitor of thrombin (Factor IIa) that plays an important role in blood coagulation. Dabigatran and its acyl glucuronide metabolites bind reversibly with thrombin and inhibit its coagulatory activity. The antibody binds to thrombin-bound dabigatran and its metabolites in a 1:1 ratio with very high affinity (? 350-fold higher than dabigatran affinity for thrombin) and thus prevents thrombin inhibition. The original drug was approved by the FDA to treat patients requiring emergency surgery or having an uncontrolled bleeding condition
Biovision | A2169 | Anti-Dabigratan (Idarucizumab), Humanized Antibody DataSheet
Antibody Target: Dabigatran
Target Alternative Name: aDabi-Fab, BI 655075, BI-655075, BI655075, dabigatran etexilate mesylate
Tag Line: The biosimilar is a humanized monoclonal antibody that binds to dabigatran and prevents its anticoagulatory effect in patients with an uncontrolled bleeding condition or those requiring surgery/urgent procedures
Category: Biosimilars
Host: Recombinant
Isotype: Fab - G1 - kappa
Species Reactivities:
Immunogen Sequence: Dabigatran etexilate mesylate
Accession #: DB09264
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application: In vitro studies
Positive Control:
Application And Usages: In vitro studies
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE