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Biovision

  • Auranofin

    Biovision | Auranofin | 2219

    An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages...

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  • Digoxin

    Biovision | Digoxin | 2911

    Digoxin is a cardiac glycoside from the leaves of Digitalis lanata. It is used to treat cardiac arrhythmias. It is often used as a model substrate of P-glycoprotein (0.01-10 µM) and an inhibitor of...

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  • L-Selenomethionine

    Biovision | L-Selenomethionine | 2408

    A potent antioxidant that enhances the activity of glutathione peroxidase in endothelial cells. It induces p53-mediated cell cycle arrest and apoptosis in human colon cancer cells.L-Selenomethionine...

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  • Thiostrepton

    Biovision | Thiostrepton | 9677

    Thiostrepton is a large cyclic antibiotic commonly used in topical antibiotic ointments. It inhibits bacterial protein synthesis. It blocks translation by interfering with elongation factors (EF)...

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  • MHY1485

    Biovision | MHY1485 | 9419

    MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. Treatment with MHY1485 suppresses the basal autophagic flux, and this...

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  • AZ-5104

    Biovision | AZ-5104 | 9441

    AZ-5104 is an active, demethylated metabolite of AZD-9291 (Cat.No.2674). It displays similar overall activity profile with AZD-9291, but is more potent against mutant EGFR forms, while hitting the...

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  • Altiratinib

    Biovision | Altiratinib | 9563

    Altiratinib is a selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. It effectively reduces tumor burden in vivo and blocks c-MET...

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  • Fumagillin

    Biovision | Fumagillin | 2368

    Fumagillin is a meroterpenoid antibiotic isolated from Aspergillus fumigatus. An anticancer, antimicrobial, antimalarial and amoebicidal compound. Potent, selective and covalent inhibitor of...

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  • Amlexanox

    Biovision | Amlexanox | 2336

    An anti-allergy, anti-asthma and anti-diabetic agent. Improves obesity-related metabolic dysfunction in mouse models. Increases thermogenesis and weight loss, decreases steatosis and improves insulin...

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  • Eptifibatide

    Biovision | Eptifibatide | 2439

    A glycoprotein (GP) IIa/IIIb inhibitor. Eptifibatide inhibits platelet aggregation by reversibly binding to the platelet receptor glycoprotein (GP) IIb/IIIa of human platelets, thus preventing the...

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  • Lubiprostone

    Biovision | Lubiprostone | B1319

    Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1 that activates ClC-2 and CFTR chloride channels. It has been suggested that lubiprostone opens CFTR or both CFTR and ClC-2...

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  • Amifostine

    Biovision | Amifostine | 2377

    Cell-permeable. A broad spectrum radio- and chemoprotective agent. Prevents chemotherapy-induced apoptosis, upregulates HIF-1α and restores transcriptional activity in specific p53 mutants.Amifostine...

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  • Ceftazidime

    Biovision | Ceftazidime | B1523

    Contains ~10% Na2CO3. Ceftazidime is a third-generation cephalosporin and a broad-spectrum antibiotic. used to study the effect of expression, binding and inhibition of penicillin-binding proteins...

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  • Atorvastatin

    Biovision | Atorvastatin | 2278

    A cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase (IC₅₀ = 154 nM) a rate limiting enzyme in cholesterol synthesis. Blocks the...

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  • Ketorolac

    Biovision | Ketorolac | B2170

    Ketorolac is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selectively inhibits the enzymes COX-1 and COX-2. The...

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  • Latanoprost

    Biovision | Latanoprost | B1320

    Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α (17-phenyl-13,14-dihydro PGF2α). It is a prodrug of the free acid, that acts as a potent agonist of the FP receptor in...

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  • Moclobemide

    Biovision | Moclobemide | 9561

    Moclobemide is a reversible, slow-binding monoamine oxidase A (MOA-A) inhibitor (IC₅₀ = 500 µM). Displays antidepressant, anxiolytic, neuroprotective and anti-ischemic effects in vivo. Blood-brain...

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  • Enrofloxacin

    Biovision | Enrofloxacin | B2101

    Enrofloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA gyrase. Enrofloxacin displays high bioavailability in most species and rapid absorption after oral,...

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  • PMSF

    Biovision | PMSF | 1548

    An irreversible inhibitor of serine proteases (such as thrombin, trypsin and chymotrypsin) and mammalian acetylcholinesterase. It causes sulfonylation of the active-site serine residues. Inhibits...

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  • Lamotrigine

    Biovision | Lamotrigine | B1234

    Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC₅₀ values of 10, 62, and 96 μM, respectively. Also blocks heterologously expressed...

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  • Hygromycin B

    Biovision | Hygromycin B | 2589

    Hygromycin B is an aminoglycoside antibiotic produced by Streptomyces hygroscopicus that is routinely used as a selection agent for cells that contain hph or hyg Hygromycin resistant gene. Hygromycin...

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  • Lonidamine

    Biovision | Lonidamine | B1058

    Lonidamine is a derivative of indazole-3-carboxylic acid that inhibits glycolysis by the inactivation of hexokinase, an enzyme that catalyzes glucose as the first step in glycolysis. Also blocks CFTR...

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  • Miglitol

    Biovision | Miglitol | 2335

    An α-glucosidase inhibitor which induces an enhanced and prolonged release of glucagon-like peptide-1, regulating appetite and stabilizing body weight in humans. Displays anti-atherothrombotic effect...

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  • Ciclopirox

    Biovision | Ciclopirox | B2079

    Ciclopirox is a synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations,...

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  • Tobramycin

    Biovision | Tobramycin | B1537

    Tobramycin is an aminoglycoside antibiotic that binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also...

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  • Roxithromycin

    Biovision | Roxithromycin | 9621

    Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds...

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  • Ribavirin

    Biovision | Ribavirin | 2199

    Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5’-phosphate, affects virus-infected cells...

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  • Nateglinide

    Biovision | Nateglinide | B2109

    Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues,...

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  • Mycophenolic Acid

    Biovision | Mycophenolic Acid | 1882

    An Immunosuppressive agent that displays antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase in the guanosine monophosphate pathway. Also...

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  • Fenbendazole

    Biovision | Fenbendazole | 2157

    An anthelmintic drug belonging to the benzimidazole group mainly used for the treatment of pinworm in animals. Recently, fenbendazole has been shown to selectively induce cytotoxicity in cancer cells...

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  • Argatroban

    Biovision | Argatroban | 9670

    Agatroban is a potent and competitive thrombin inhibitor (Ki = 19 nM) that displays anticoagulant activity. Active in vivo.Agatroban is a potent and competitive thrombin inhibitor (Ki = 19 nM) that...

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  • Captopril

    Biovision | Captopril | B1187

    Captopril is an angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ = 0.022 μM). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and...

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  • Nimesulide

    Biovision | Nimesulide | 2777

    Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor. The IC₅₀ values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for...

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  • Sodium butyrate

    Biovision | Sodium butyrate | 1609

    A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes...

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  • Menadione

    Biovision | Menadione | 2747

    Menadione is an inhibitor of indoleamine2,3-dioxygenase (IDO) (IC₅₀ ~ 1 µM). It induces apoptosis via elevation of peroxide radical levels. Cytotoxic in various cell lines.Menadione is an inhibitor...

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  • Sulfamethoxazole

    Biovision | Sulfamethoxazole | B1534

    Sulfamethoxazole is an antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Inhibits folic acid synthesis in prokaryotesSulfamethoxazole is an...

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  • Metronidazole

    Biovision | Metronidazole | 9522

    Metronidazole is a nitroimidazole compound that acts as an antiprotozoal drug but it is also active against bacteria. Used to treat bacterial, fungal and parasitic infections.Metronidazole is a...

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  • Felodipine

    Biovision | Felodipine | 2399

    A potent L-type Ca²⁺channel blocker that is selective over N-, R-, P/Q- and T-type channels. It displays high vascular selectivity over cardiac muscle, thus lowering arterial blood pressure without...

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  • Oxfendazole

    Biovision | Oxfendazole | B2391

    A broad spectrum benzimidazole anthelmintic. Mainly used for protecting livestock against roundworm, strongyles and pinworms. Oxfendazole is the sulfoxide metabolite of fenbendazole.A broad spectrum...

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  • Ramipril

    Biovision | Ramipril | B2133

    Ramipril is a non-peptide, angiotensin converting enzyme (ACE) inhibitor (IC₅₀ = 5 nM). A prodrug that is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on...

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  • Rifampicin

    Biovision | Rifampicin | B1511

    Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death. Active...

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  • Thiabendazole

    Biovision | Thiabendazole | 2161

    A fungicide and a parasiticide. Inhibits angiogenesis in both human cells in vitro and in Xenopus embryos in vivo at a concentration of 100-250 µM. Also acts as a vascular disrupting agent (VDA)...

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  • Azathioprine

    Biovision | Azathioprine | 9536

    Azathioprine is a purine analog that displays immunosuppressive and anti-inflammatory properties. It serves as a prodrug for 6-mercaptopurine, which alters purine processing and DNA synthesis,...

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  • Carbamazepine

    Biovision | Carbamazepine | B2401

    Carbamazepine is an inhibitor of neuronal voltage-gated Na+ channels. It displays anticonvulsant activity and potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor...

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  • Busulfan

    Biovision | Busulfan | B1063

    Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. Busulfan causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions...

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  • Disulfiram

    Biovision | Disulfiram | 2308

    An alcohol dehydrogenase inhibitor used for the treatment of chronic alcoholism. Suppresses the invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. Also inhibits...

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  • Chloramphenicol

    Biovision | Chloramphenicol | 2486

    Chloramphenicol is a bacteriostatic antibiotic that inhibits bacterial protein synthesis. Displays a broad spectrum antibiotic activity targeting a wide variety of gram positive and gram negative...

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  • Isradipine

    Biovision | Isradipine | 2564

    Cell-permeable. A potent and selective voltage-gated L-type calcium channel blocker. Displays antiatherosclerotic effects and improves endothelium-mediated nitric oxide-dependent vasodilation...

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  • Dofetilide

    Biovision | Dofetilide | B1189

    Dofetilide is a class III antiarrhythmic agent and inhibits the rapid delayed rectifier K⁺current (IKr) with IC₅₀values of 31.5 nM in guinea pig cardiomyocytes. At higher doses it demonstrates...

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  • Albendazole

    Biovision | Albendazole | B2100

    Albendazole is a broad-spectrum, synthetic benzimidazole-derivative anthelmintic. It interferes with the reproduction and survival of helminths by inhibiting the formation of microtubules from...

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