Biovision

Quick view

Biovision | Bafetinib | B1172

Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl, Lyn inhibitor with IC₅₀ values of 5.8 nM and 19 nM, respectively.Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl, Lyn...

MSRP:

Was:

Now: NULL271.00 - NULL779.00

Choose Options Compare
Quick view

Biovision | NVP-AEW541 | B1335

NVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase.NVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase.Biovision | B1335 | NVP-AEW541 DataSheetAlternate...

MSRP:

Was:

Now: NULL369.00 - NULL1,107.00

Choose Options Compare
Quick view

Biovision | ZSTK474 | 1597

ZSTK474 is a reversible, potent and specific inhibitor of phosphoinositide 3-kinase (PI3K) isoforms ((IC₅₀s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). More effective than LY 294,002 in...

MSRP:

Was:

Now: NULL288.00 - NULL697.00

Choose Options Compare
Quick view

Biovision | SCH772984 | B1682

SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.Biovision |...

MSRP:

Was:

Now: NULL239.00 - NULL771.00

Choose Options Compare
Quick view

Biovision | LY-411575 | 2648

LY411575 is a potent, cell-permeable γ-secretase inhibitor (IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based); also inhibits Notch clevage with with IC₅₀ of 0.39 nM. Notch inhibition using LY-411575...

MSRP:

Was:

Now: NULL222.00 - NULL631.00

Choose Options Compare
Quick view

Biovision | Senicapoc | B2390

Senicapoc (ICA-17043) is a potent and selective Gardos channel blocker (IC₅₀ = 11 nM). Senicapoc (ICA-17043) could be a potential drug for the prevention and treatment of hemolysis-associated...

MSRP:

Was:

Now: NULL222.00 - NULL567.00

Choose Options Compare
Quick view

Biovision | Tivantinib | B1546

Tivantinib (ARQ-197) is a potent, cell-permeable inhibitor of c-Met with potential antineoplastic activity. Tivantinib binds to the c-Met protein and disrupts c-Met signal transduction pathways,...

MSRP:

Was:

Now: NULL222.00 - NULL631.00

Choose Options Compare
Quick view

Biovision | JNJ-38877605 | B2063

JNJ-38877605 is a potent c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (IC₅₀ values of 4 nM and 50 nM for c-MET enzyme and Phospho-MET respectively). Displays...

MSRP:

Was:

Now: NULL354.00 - NULL1,148.00

Choose Options Compare
Quick view

Biovision | Azeliragon | B1152

Azeliragon is a potent RAGE (the receptor for advanced glycation end products) inhibitor. It has been evaluated for potential treatment for patients with mild-to-moderate Alzheimer's disease (AD)...

MSRP:

Was:

Now: NULL354.00 - NULL1,148.00

Choose Options Compare
Quick view

Biovision | Apixaban | B1855

Apixaban is a potent, selective inhibitor of both free and prothrombinase-bound factor Xa (Ki = 0.8 nM). Apixaban is an effective anticoagulant in both preclinical and clinical models of venous and...

MSRP:

Was:

Now: NULL222.00 - NULL631.00

Choose Options Compare
Quick view

Biovision | A-769662 | 1719

Cell-permeable. A potent AMPK activator. Directly stimulates partially purified rat liver AMPK (EC₅₀ = 0.8 µM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC5₅₀ = 3.2 µM).A-769662...

MSRP:

Now: NULL501.00
Add to Cart Compare
Quick view

Biovision | AT9283 | 2432

A pan-Aurora kinase inhibitor (IC₅₀ = 3 nM for both Aurora A and B). AT9283 also potently inhibits several kinases including the JAK2 and 3 (IC₅₀’s 1.2 and 1.1 nM, respectively), c-Abl(IC₅₀ = 110 nM)...

MSRP:

Was:

Now: NULL303.00 - NULL894.00

Choose Options Compare
Quick view

Biovision | Nucleozin | B2064

Nucleozin is an antiviral agent that triggers the aggregation of nucleoprotein (NP) and inhibits its nuclear accumulation. Nucleozin impedes influenza A virus replication in vitrowith a nanomolar...

MSRP:

Was:

Now: NULL271.00 - NULL828.00

Choose Options Compare
Quick view

Biovision | Triptolide | 1761

Triptolide, a diterpenoid triepoxyde, a purified component of a traditional Chinese medicine, inhibits transcriptional activation of NF- κB and downregulates the expression of various NF-...

MSRP:

Was:

Now: NULL197.00 - NULL533.00

Choose Options Compare
Quick view

Biovision | Neratinib | 2023

Cell-permeable. A second-generation inhibitor of the ErbB family of receptor kinases. Neratinib acts as an irreversible inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal...

MSRP:

Was:

Now: NULL386.00 - NULL1,271.00

Choose Options Compare
Quick view

Biovision | Clemizole | 2481

Clemizole is a H1-histamine receptor antagonist. Recently, Clemizole has been shown to inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.Clemizole is a H1-histamine receptor...

MSRP:

Was:

Now: NULL222.00 - NULL631.00

Choose Options Compare
Quick view

Biovision | GSK137647A | B1112

GSK137647A is a a selective agonist of FFA4 (GPR120) (pEC₅₀s = 6.3, 6.2, and 6.1 at human, mouse, and rat receptors, respectively). It is selective for GPR120 over a panel of 61 other targets,...

MSRP:

Was:

Now: NULL239.00 - NULL697.00

Choose Options Compare
Quick view

Biovision | 3-Bromopyruvic acid | B1045

3-Bromopyruvic acid is a hexokinase inhibitor that has been shown to abolish ATP production and cause severe depletion of cellular ATP. It displays potent cytotoxic activity against cancer cells with...

MSRP:

Was:

Now: NULL173.00 - NULL239.00

Choose Options Compare
Quick view

Biovision | BML-284 | B1077

BML-284 is cell-permeable Wnt signaling pathway agonist. It mimics the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt...

MSRP:

Was:

Now: NULL288.00 - NULL877.00

Choose Options Compare
Quick view

Biovision | PRIMA-1 | 2170

A small molecule that restores tumor suppressor function to mutant p53 proteins. PRIMA-1 acts as an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. PRIMA-1 restores...

MSRP:

Was:

Now: NULL231.00 - NULL590.00

Choose Options Compare
Quick view

Biovision | PRIMA-1MET | 9485

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 2170). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. At...

MSRP:

Was:

Now: NULL239.00 - NULL697.00

Choose Options Compare
Quick view

Biovision | YU238259 | B2155

YU238259 is a potent inhibitor of Homology-Dependent DNA Repair (HDR). YU238259 displays potent synthetic lethality in the setting of DNA damage response and DNA repair defects. YU238259 specifically...

MSRP:

Was:

Now: NULL288.00 - NULL894.00

Choose Options Compare
Quick view

Biovision | ML239 | 2696

ML239 is a selective inhibitor of breast cancer stem cells. It inhibits cancer stem cells with an IC₅₀ of 1.16 μM with 24-fold selectivity against the control cell line. ML239 alters the expression...

MSRP:

Was:

Now: NULL254.00 - NULL763.00

Choose Options Compare
Quick view

Biovision | YM-90709 | B1074

YM-90709 is a selective inhibitor of interleukin-5 (IL-5). YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15...

MSRP:

Was:

Now: NULL320.00 - NULL894.00

Choose Options Compare
Quick view

Biovision | GDC-0084 | B1656

Biovision | GDC-0084 | B1656

MSRP:

Now: NULL207.00
Add to Cart Compare
Quick view

Biovision | Mirin | B1075

Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Mirin blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double...

MSRP:

Was:

Now: NULL303.00 - NULL959.00

Choose Options Compare
Quick view

Biovision | CH5183284 | B1649

CH5183284 is a selective and orally available FGFR1/2/3 inhibitor. The IC50 values of CH5183284 on the enzyme activity of FGFR1/2/3/4 were 9.3, 7.6, 22, and 290 nM, respectively.CH5183284 is a...

MSRP:

Was:

Now: NULL247.00 - NULL739.00

Choose Options Compare
Quick view

Biovision | PF-06291874 | B2001

PF-06291874 is a glucagon receptor antagonist potentially useful for patients with type 2 diabetes mellitus.PF-06291874 is a glucagon receptor antagonist potentially useful for patients with type 2...

MSRP:

Was:

Now: NULL288.00 - NULL894.00

Choose Options Compare
Quick view

Biovision | Eptapirone | B1123

Eptapirone (also known as F11440 ), is a potent and selective 5HT1A receptor agonist showing anxiolytic and antidepressant properties.Eptapirone (also known as F11440 ), is a potent and selective...

MSRP:

Was:

Now: NULL303.00 - NULL959.00

Choose Options Compare
Quick view

Biovision | MK-1064 | B1641

MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.Biovision | B1641 |...

MSRP:

Was:

Now: NULL427.00 - NULL1,311.00

Choose Options Compare
Quick view

Biovision | Fruquintinib | B1979

Fruquintinib (HMPL-013) is a potent and selective vascular endothelial growth factor receptors1/2/3 (VEGFR 1/2/3) inhibitor with IC₅₀s of 33, 0.35, and 35 nM, respectively. It only weakly inhibits...

MSRP:

Was:

Now: NULL288.00 - NULL894.00

Choose Options Compare
Quick view

Biovision | AZD-5069 | B2053

AZD-5069 is a potent and reversible CXCR2 chemokine receptor antagonist with potential anti-inflammatory and antineoplastic activities. Upon administration, CXC chemokine receptor 2 antagonist...

MSRP:

Was:

Now: NULL337.00 - NULL1,058.00

Choose Options Compare
Quick view

Biovision | SC66 | 1870

Cell-permeable. An allosteic Akt inhibitor that directly facilitates Akt ubiquitination in vitro and in vivo. SC66 displays a dual inhibitory activity that directly interferes with the pleckstrin...

MSRP:

Was:

Now: NULL214.00 - NULL590.00

Choose Options Compare
Quick view

Biovision | 3PO | B2018

3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be a useful agent in combination with other drugs...

MSRP:

Was:

Now: NULL239.00 - NULL697.00

Choose Options Compare
Quick view

Biovision | PRT4165 | B1054

PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity...

MSRP:

Was:

Now: NULL222.00 - NULL631.00

Choose Options Compare
Quick view

Biovision | STO-609 | B1609

STO-609 is a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinaseSTO-609 is a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinaseBiovision | B1609 | STO-609...

MSRP:

Was:

Now: NULL354.00 - NULL1,107.00

Choose Options Compare
Quick view

Biovision | RS-1 | B1118

RS-1 (RAD51-stimulatory compound 1) is a high affinity stimulator of the human homologous recombination (HR) protein RAD51. RS-1 stimulates binding of hRAD51 to single stranded DNA (ssDNA) and...

MSRP:

Was:

Now: NULL271.00 - NULL828.00

Choose Options Compare
Quick view

Biovision | GSK2981278 | B1195

GSK-2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).GSK-2981278 is a highly potent and selective inverse agonist of...

MSRP:

Was:

Now: NULL271.00 - NULL631.00

Choose Options Compare
Quick view

Biovision | A-1331852 | B1948

A-1331852 is a potent anti-apoptotic Bcl-xL protein inhibitor and apoptosis-inducing agent useful in the treatment of cancer, immune and autoimmune diseases.A-1331852 is a potent anti-apoptotic...

MSRP:

Was:

Now: NULL354.00 - NULL1,148.00

Choose Options Compare
Quick view

Biovision | TY-52156 | B1582

TY-52156 is a novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell...

MSRP:

Was:

Now: NULL303.00 - NULL959.00

Choose Options Compare
Quick view

Biovision | Olmutinib | B1218

Olmutinib (BI 1482694), is a third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI). It inhibits both EGFR activating and T790M resistance...

MSRP:

Was:

Now: NULL271.00 - NULL828.00

Choose Options Compare
Quick view

Biovision | Naquotinib | B1317

Naquotinib is a potent, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor that displays antineoplastic activity. Naquotinib preferentially inhibits...

MSRP:

Was:

Now: NULL288.00 - NULL894.00

Choose Options Compare
Quick view

Biovision | A-1155463 | B1821

A-1155463 is a highly potent and selective BCL-XL inhibitor. A-1155463 is more potent against BCL-XL-dependent cell lines relative to WEHI-539 (Cat. No. B1819), while possessing none of its inherent...

MSRP:

Was:

Now: NULL329.00 - NULL1,050.00

Choose Options Compare
Quick view

Biovision | Miransertib | B1931

Miransertib is an allosteric, pan-Akt inhibitor (IC₅₀s = 5.0, 4.5, and 16 nM for Akt1, Akt2, and Akt3, respectively). It is selective for Akt isoforms over a panel of 303 other kinases. It binds to...

MSRP:

Was:

Now: NULL320.00 - NULL1,024.00

Choose Options Compare
Quick view

Biovision | LJH685 | B1232

LJH685 is a potent and specific RSK (p90 ribosomal S6 kinase) inhibitor. Inhibits RSK1, 2, and 3 biochemical activities with IC₅₀ values of 4 to 13 nM.LJH685 is a potent and specific RSK (p90...

MSRP:

Was:

Now: NULL239.00 - NULL697.00

Choose Options Compare
Quick view

Biovision | trans-Zeatin | 2542

trans-Zeatin belongs to the plant hormone family known as ‘cytokinins’, which regulate cell division, development, and nutrient processing. The biosynthesis of cytokinins involves isoprenylation of...

MSRP:

Was:

Now: NULL205.00 - NULL501.00

Choose Options Compare
Quick view

Biovision | NQDI-1 | 9645

NQDI-1 is a specific inhibitor of apoptosis signal-regulating kinase 1 (ASK1) (IC₅₀ = 3 μM; Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein...

MSRP:

Was:

Now: NULL288.00 - NULL894.00

Choose Options Compare
Quick view

Biovision | I-CBP112 | 9405

I-CBP112 is a selective CBP/EP300 bromodomain inhibitor (IC₅₀ values of 170 nM, 170 nM, 151 nM and 625 nM for CREBBP(Alphascreen), CREBBP(BLI), CREBBP(ITC) and EP300(ITC),respectively). Selective for...

MSRP:

Was:

Now: NULL205.00 - NULL567.00

Choose Options Compare
Quick view

Biovision | Maytansinol | B2015

Maytansinol is a potent microtubule depolymerizing agent. It inhibits the polymerization of tubulin and depolymerizes the once polymerized tubulin.Maytansinol is a potent microtubule depolymerizing...

MSRP:

Was:

Now: NULL303.00 - NULL959.00

Choose Options Compare
Quick view

Biovision | FPS-ZM1 | B1933

FPS-ZM1 is a high-affinity, brain-permeable, RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can...

MSRP:

Was:

Now: NULL205.00 - NULL567.00

Choose Options Compare
Quick view

Biovision | Rocaglamide | 1863

An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits...

MSRP:

Now: NULL681.00
Add to Cart Compare
Quick view

Biovision | Lifitegrast | B1917

Lifitegrast is a LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is...

MSRP:

Was:

Now: NULL271.00 - NULL828.00

Choose Options Compare