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Biovision | BV6 | B1332

BV6 is a selective inhibitor of IAP proteinsBV6 is a selective inhibitor of IAP proteinsBiovision | B1332 | BV6 DataSheetAlternate Name/Synonyms:...

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Biovision | Nexturastat A | 2098

Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC₅₀ = 5.02 ± 0.60 nM). Displays 600-, 1380-, 1330-, 1870-, -2330,...

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Biovision | TAPI-1 | 2068

Inhibitor of TNF-α processing (IC₅₀ = 100 nM), similar to TAPI-0 (Cat. No. 2067-1), but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α...

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Biovision | CNX-1351 | B1673

CNX1351 is a potent and selective inhibitor of PI3Kα with IC50 value of 6.8 nMCNX1351 is a potent and selective inhibitor of PI3Kα with IC50 value of 6.8 nMBiovision | B1673 | CNX-1351...

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Biovision | Brefeldin A | 1560

Brefeldin A has been shown to induce apoptosis in human tumor cells through caspase activation. It has also been shown to block translocation of proteins from the endoplasmic reticulum to the Golgi...

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Biovision | Birinapant | 2597

Birinapant is a SMAC (synthetic small molecule and peptidomimetic of second mitochondrial-derived activator of caspases) mimetic and IAP (Inhibitor of Apoptosis Protein) antagonist with potential...

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Biovision | PFI-1 | 2203

PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC₅₀...

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Biovision | VS-5584 | 9603

VS-5584 is a potent and selective PI3K/mTOR kinase inhibitor. It inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant...

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Biovision | Sapacitabine | B2002

Sapacitabine is an orally bioavailable nucleoside analog prodrug that is potentially useful for treatment of hematologic malignancies and solid tumors. The active metabolite of sapacitabine, CNDAC...

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Biovision | Briciclib | B1140

Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is...

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Biovision | Nimorazole | 9521

Nimorazole is a 5-nitroimidazole derivative that displays antimicrobial activity. Used in the treatment of intestinal protozoal infections. Also acts as a hypoxic radiosensitizer.Nimorazole is a...

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Biovision | Kartogenin | 2066

Cell-permeable. Kartogenin promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes (EC₅₀ = 100 nM). Displays chondroprotective effects in vitro and is...

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Biovision | Ethynylcytidine | B1266

Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. Ethynylcytidine is metabolized in tumor...

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Biovision | Cilengitide | B2365

Cilengitide is a cyclo-(Arg-Gly-Asp-D-Phe-Val) (cRGDfV) peptide that acts as an integrin αVβ3 receptor antagonist. It inhibits adhesion and induces apoptosis of U87MG and U373MG malignant glioma (MG)...

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Biovision | BMS-303141 | 2821

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL) (IC₅₀ = 0.13 µM for human recombinant ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC₅₀ of 8 μM, and lowers plasma...

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Biovision | Arglabin | 9691

Arglabin is a potent anti-inflammatory and anticancer agent. It also acts as a Farnesyltransferase inhibitor and antiatherogenic compound. Prevents the accumulation of lipid containing plaques in...

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Biovision | ACTB-1003 | B2016

ACTB-1003 is a potent kinase inhibitor with IC₅₀s of 6, 2 and 4 nM for FGFR1, VEGFR2 and Tie-2, respectively. Displays anticancer activities.ACTB-1003 is a potent kinase inhibitor with IC₅₀s of 6, 2...

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Biovision | Citarinostat | B1560

Citarinostat (ACY-241), is a potent, selective and orally available histone deacetylase 6 (HDAC6) inhibitor with IC₅₀ values of 4 nM and 76 nM for HDAC6 and HDAC3, respectively. Displays...

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Biovision | SM-164 | B1816

SM-164 is a potent cell-permeable and bivalent Smac mimetic which binds to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM,...

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Biovision | CTx-0294885 | 9435

CTx-0294885 is a broad-spectrum kinase inhibitor. CTx-0294885 displays inhibitory activity against a broad range of kinases in vitro. CTx-0294885 could be a potentially powerful new tool for analysis...

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Biovision | P7C3-A20 | 2850

P7C3-A20 is a derivative of P7C3 (Cat. No. 2849), and is a proneurogenic, neuroprotective agent. P7C3-A20 displays increased activity and an improved toxicity profile compared to P7C3...

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Biovision | P7C3 | 2849

P7C3 is an aminopropyl carbazole derivative that acts as a proneurogenic, neuroprotective compound. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and...

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Biovision | Uprosertib | B1760

Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.Uprosertib,...

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Biovision | DBeQ | 1858

Cell- permeable. A potent, selective, reversible, and ATP-competitive p97 inhibitor. DBeQ blocks both ubiquitin-dependent and autophagic protein clearance pathways and rapidly promotes executioner...

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Biovision | X-GAL | 2671

X-GAL is a useful chromogenic substrate for β-galactosidase that produces a rich blue color that can easily be detected visually over background. X-GAL is used to indicate whether a cell expresses...

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Biovision | Luminol | B1807

Luminol is a useful probe that displays chemiluminescence upon oxidation. Horseradish peroxidase (HRP), combined with hydrogen peroxide as an activator, causes luminescent peroxidation of luminol...

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Biovision | DTT | 1201

An excellent reagent for maintaining SH groups in reduced state. DTT quantitatively reduces disulfides. It is effective in sample buffers for reducing protein disulfide bonds prior to SDSPAGE.DTT is...

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Biovision | DTE | B2410

A useful reagent for maintaining sulfhydryl groups in the reduced stateDTE is a useful reagent for maintaining sulfhydryl groups in the reduced stateBiovision | B2410 | DTE DataSheetAlternate...

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Biovision | Y-320 | B1164

Y-320 is an immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.Y-320 is an immunomodulator. Y-320 inhibits IL-17 production by CD4 T...

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Biovision | DMOG | 2216

A cell-permeable prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic...

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Biovision | PTC-209 | B1055

PTC-209 is a potent, cell-permeable, BMI-1 inhibitor (IC₅₀ = 0.5 µM) with potential anticancer activity. PTC-209 lowers the self-renewal properties of colorectal cancer-initiating cells (CICs)...

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Biovision | TCS JNK 5a | B1688

TCS JNK 5a (JNK Inhibitor IX) is a selective inhibitor of JNK2 and JNK3; displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0)...

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Biovision | Inauhzin | 9555

Inauhzin is a potent SIRT inhibitor that effectively reactivates p53 by inhibiting SIRT1 activity. Inauhzin inhibits cell proliferation, induces senescence, and p53-dependent apoptosis of human...

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Biovision | HS-173 | B1627

HS-173 is a novel PI3K inhibitor, that is used for cancer treatment. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells.HS-173 is a novel PI3K...

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Biovision | FLI-06 | 2603

A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other...

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Biovision | Atglistatin | B1864

Atglistatin is a potent, and selective inhibitor of adipose triglyceride lipase (ATGL) the rate limiting enzyme involved in fatty acid mobilization and prevention of lipolysis. It does not inhibit...

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Biovision | AdipoRon | 2565

A potent and selective adiponectin receptor agonist (Kd = 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). Displays similar effects to adiponectin in muscle and liver such as activation of...

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Biovision | CPI-203 | 9404

CPI-203 is an analog of (+)-JQ1 (Cat. No. 2070). Acts as a BET bromodomain inhibitor. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.CPI-203...

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Biovision | SF1670 | 2774

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor (IC₅₀ = 2 µM). It specifically binds to the active site of PTEN. At nanomolar concentrations it increases cellular...

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Biovision | ID-8 | 2562

ID-8 is a cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells in vitro. At 10 μM it stimulates proliferation in serum-free media at a steady rate for...

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Biovision | SAR-260301 | B1263

SAR260301 is a potent and selective Class I phosphatidylinositol-3-kinase-β (PI3K-β) specific inhibitor with an IC₅₀ of 52 nM for this isoform. SAR260301 displays improved physicochemical and in...

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Biovision | BAY 87-2243 | B1878

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It inhibits HIF-1α and HIF-2α protein accumulation under hypoxic conditions in non-small cell lung cancer...

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Biovision | NSC 405020 | 2682

NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC₅₀ >100 μmol/L). It...

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Biovision | SGC-CBP30 | 9554

SGC-CBP30 is a potent and selective CREBBP/EP300 bromodomain inhibitor with IC values of 21-69 and 38 nM for CREBBP and EP300 bromodomains, respectively. SGC-CBP30 has little activity against other...

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Biovision | Bromosporine | 2652

Bromosporine is a broad spectrum bromodomain inhibitor (IC₅₀s = 0.41 µM, 0.29 µM, 0.122 µM and 0.017 µM for BRD2, BRD4, BRD9 and CECR2, respectively). At 1 µM, Bromosporine accelerates FRAP recovery...

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Biovision | UNC2881 | 2837

UNC2881 is a potent Mer kinase inhibitor. It inhibits steady-state Mer kinase phosphorylation with an IC₅₀ value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation...

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Biovision | HG-9-91-01 | B1849

HG-9-91-01 is a potent, selective, ATP-competitive, pan-SIK (salt-inducible kinases) inhibitor with IC₅₀ values of 0.92 nM, 6.6n M and 9.6 nM for SIK1, SIK2, SIK3, respectively.HG-9-91-01 is a...

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Biovision | PF-4708671 | 9460

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with a Ki of 20 nM and IC₅₀ of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in...

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Biovision | TAK-632 | 2473

A selective pan-RAF inhibitor with IC₅₀ Values: 2.4 nM (BRAF V600E); 1.4 nM (C-RAF); 160 nM (VEGFR). TAK-632 displays significant cellular activity against mutated BRAF or mutated NRAS cancer cell...

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Biovision | Erastin | 2231

Erastin is a selective antitumor agent that displays greater lethality in human tumour cells harbouring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent...

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Biovision | Valdecoxib | B1991

Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID), that acts as a potent and selective inhibitor of cyclooxygenase-2 (COX-2) (IC₅₀ = 5 nM).Valdecoxib is a non-steroidal anti-inflammatory...

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Biovision | Necrostatin-1 | 1864

Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in...

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