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Biovision

  • GBR-12909

    Biovision | GBR-12909 | B3043

    GBR-12909 is a potent and selective inhibitor of dopamine uptake (Ki = 1 nM). It inhibits dopamine uptake in tissue slices obtained from rat neostriatum at nanomolar concentrations. GBR-12909 (10...

    $777 - $2,237
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  • Cepharanthine

    Biovision | Cepharanthine | B3042

    Cepharanthine is an alkaloid extracted from the plant Stephania cepharantha Hayata. It shows antimalarial, antiviral, anti-inflammatory, and antitumor activities. The IC₅₀ values against different...

    $637 - $1,666
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  • Nitazoxanide

    Biovision | Nitazoxanide | B3041

    Nitazoxanide is a nitrothiazole benzamide with anti-parasitic and anti-viral activity. It inhibits pyruvate-ferredoxin oxidoreductase in protozoa and anaerobic bacteria. It inhibits many anerobes in...

    $637 - $1,666
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  • Umifenovir

    Biovision | Umifenovir | B3040

    Umifenovir is an indole derivative with broad-spectrum antiviral activity. It inhibits virus-mediated fusion with target membrane and blocks virus entry into target cells. It shows antiviral activity...

    $665 - $1,782
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  • Meglumine

    Biovision | Meglumine | B3036

    Meglumine is a derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. It is used as an excipient for drug formulations and for preparing salts. The...

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  • Tafamidis

    Biovision | Tafamidis | B3035

    Tafamidis is a potent kinetic stabilizer of transthyretin (TTR). Tafamidis binds selectively and with negative cooperativity (Kd values ∼2 nM and ∼200 nM) to the two normally unoccupied...

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  • GBT-440

    Biovision | GBT-440 | B3031

    GTB-440 is a modulator of sickle hemoglobin S (HbS). It binds to the N‐terminal valine of one of the haemoglobin α chains and increases HbS affinity for oxygen. GBT440 dose‐dependently increases HbS...

    $1,061 - $3,357
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  • Nidufexor

    Biovision | Nidufexor | B3029

    Nidufexor is an agonist of Farnesoid X receptor (FXR). Administration of Nidufexor (10 and 30 mg/kg for 3 weeks) modulates FXR-dependent genes in vivo leading to the reduction of steatosis,...

    $665 - $1,782
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  • Licogliflozin

    Biovision | Licogliflozin | B3028

    Licogliflozin is a dual inhibitor of Sodium/glucose cotransporters SGLT1 and SGLT2 with a higher selectivity for SGLT2 (in vitro IC₅₀ values of 20.6 and 0.58 nM, respectively). It causes a reduction...

    $1,061 - $3,357
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  • Aramchol

    Biovision | Aramchol | B3027

    Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It...

    $665 - $1,782
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  • Cenicriviroc

    Biovision | Cenicriviroc | B3026

    Cenicriviroc is a potent inhibitor of C-C chemokine receptors CCR5 and CCR2. It is an orally bioavailable derivative of TAK-779 with potent anti-HIV-1 activity. It blocks the binding of MIP-1α and...

    $749 - $2,125
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  • Tucatinib

    Biovision | Tucatinib | B3025

    Tucatinib is an oral, potent, selective and ATP-competitive small-molecule inhibitor of Receptor tyrosine-protein kinase ErbB2 (also called HER2 or human epidermal growth factor receptor 2) with an...

    $665 - $1,666
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  • Ertapenem sodium

    Biovision | Ertapenem sodium | B3024

    Ertapenem is a carbapenem broad spectrum antibiotic effective against Gram-positive and Gram-negative bacteria. It binds to the penicillin binding proteins (PBPs) and has high affinity for PBPs 2 and...

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  • Famotidine

    Biovision | Famotidine | B3021

    Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine...

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  • Narasin

    Biovision | Narasin | B3020

    Narasin is an ionophore antibiotic which is a derivative of salinomycin. It modifies the permeability of cellular membranes to cationic metal species. It inhibits NF-κB signaling via inhibition of...

    $718 - $1,985
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  • AMG-517

    Biovision | AMG-517 | B3019

    AMG-517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1) with an IC₅₀ of 0.9 nM. It inhibits post-burn mechanical and thermal allodynia in a rat model of burn injury when...

    $980 - $3,042
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  • LM22B-10

    Biovision | LM22B-10 | B3018

    LM22B-10 is an activator of Tropomyosin-receptor kinase neurotrophin receptors TrkB and TrkC. It binds to TrkB and TrkC in a dose-dependent manner at concentrations of 250 nM-2000 nM. It increases...

    $1,239 - $4,018
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  • Ro 08-2750

    Biovision | Ro 08-2750 | B3017

    Ro 08-2750 is an antagonist of nerve growth factor (NGF). It binds to the NGF dimer (Kd ~ 1 μM) and probably induces a change in its conformation such that NGF cannot bind to neurotrophin receptor...

    $1,239 - $4,018
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  • ML-193

    Biovision | ML-193 | B3016

    ML-193 is a selective quinoline aryl sulfonamide antagonist for GPR55, a lysophosphatidylinositol (LPI)-sensitive receptor that is also involved in cannabinoid signaling. It inhibits GPR55 with an...

    $1,008 - $3,129
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  • Istradefylline

    Biovision | Istradefylline | B3013

    Istradefylline is an adenosine receptor 2A (A2A) antagonist with a Ki value of 2.2 nM in a radioligand binding assay. Oral administration of Istradefylline reverses motor disability without inducing...

    $665 - $1,782
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  • MGL-3196

    Biovision | MGL-3196 | B3010

    A selective thyroid hormone receptor β agonist with EC₅₀ values of 0.21 and 3.74 µM for THRβ and THRα, respectively. It significantly lowers non-HDL-C and liver TG in hypercholesterolemic rat and...

    $665 - $1,754
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  • Alofanib

    Biovision | Alofanib | B3009

    Alofanib is a novel selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase. It inhibits phosphorylation of FGF receptor substrate 2α (FRS2α) with IC₅₀ values of...

    $1,061 - $3,385
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  • Roblitinib

    Biovision | Roblitinib | B3008

    Roblitinib is a reversible-covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) tyrosine kinase. It shows 1000-fold selectivity for FGFR4 over FGFR1/2/3 and other kinases, with an IC₅₀...

    $665 - $1,754
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  • Merestinib

    Biovision | Merestinib | B3007

    Merestinib is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM. It shows more anti-proliferative activity in cell lines with MET gene...

    $718 - $1,985
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  • Savolitinib

    Biovision | Savolitinib | B3006

    Savolitinib is an inhibitor of cMET tyrosine kinase or hepatocyte growth factor receptor (HGFR). It potently inhibits the tyrosine kinase activity of recombinant cMET in vitro with an IC₅₀ value of 4...

    $718 - $1,985
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  • Capmatinib

    Biovision | Capmatinib | B3005

    Capmatinib is an ATP competitive inhibitor of c-MET kinase or hepatocyte growth factor receptor (HGFR). Binding of Hepatocyt Growth Factor to c-MET receptor causes activation of multiple downstream...

    $718 - $1,985
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  • Theliatinib

    Biovision | Theliatinib | B3004

    Theliatinib is a potent epidermal growth factor receptor EGFR tyrosine kinase inhibitor with a Ki value of 0.05 nM and IC₅₀ of 3 nM. It exhibits strong antitumor activity in patient-derived estrogen...

    $1,120 - $3,616
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  • Icotinib

    Biovision | Icotinib | B3003

    Icotininb is a potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC₅₀ of 5 nM. It blocks EGFR-mediated intracellular tyrosine phosphorylation IC₅₀ of 45 nM in the...

    $980 - $3,042
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  • Allitinib

    Biovision | Allitinib | B3002

    Allitinib is a novel anilino-quinazoline compound that inhibits ErbB tyrosine kinases: epidermal growth factor receptor (EGFR) and ErbB2. It inhibits EGFR and ErbB2 with IC₅₀ values of 0.5 nM and 3...

    $1,008 - $3,129
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  • Avapritinib

    Biovision | Avapritinib | B2999

    Avapritinib is an inhibitor of oncogenic KIT and PDGFRA mutations. The KIT receptor belongs to the class III receptor tyrosine kinase (RTK) family. Avapritinib potently inhibits the activation loop...

    $718 - $1,985
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  • Branebrutinib

    Biovision | Branebrutinib | B2998

    Branebrutinib is a potent covalent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor tyrosine kinase. It is a member of the Tec family of kinases and is essential for B...

    $889 - $2,699
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  • Remdesivir

    Biovision | Remdesivir | B2997

    Remdesivir is a nucleoside analogue with antiviral activity. It inhibits Middle East respiratory syndrome coronavirus (MERS-CoV)- or severe acute respiratory syndrome coronavirus (SARS-CoV)-infected...

    $837 - $1,985
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  • Selpercatinib

    Biovision | Selpercatinib | B2996

    Selpercatinib is a RET kinase inhibitor with IC₅₀ values ranging from 1 nM to 4 nM for wild type and mutant RET kinase. It has shown promising results in early phase clinical trials for RET-driven...

    $718 - $1,985
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  • Avitinib

    Biovision | Avitinib | B2995

    Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR) receptor tyrosine kinase. It inhibits EGFR L858R/T790M double mutations with an IC₅₀ value...

    $949 - $2,898
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  • CMPD-1

    Biovision | CMPD-1 | B2991

    MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a...

    $718 - $1,894
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