Reagents

Biovision | Monosodium Urate (crystals) | 9689

Monosodium Urate (MSU) is a NLRP3/NALP3 inflammasome activator. Stimulates the caspase-1 activating NLRP3/NALP3 (cryopyrin) inflammasome, resulting in the production of active IL-1β and IL-18. Specially crystallized and tested for biological activity...

Biovision | MMP-9 Inhibitor | 1981

Cell-permeable. A potent, selective, and reversible MMP-9 Inhibitor (IC₅₀ = 5 nM). Inhibits MMP-1 (IC₅₀ = 1.05 µM) and MMP-13 (IC₅₀ = 113 nM) only at much higher concentrations.MMP-9 inhibitor is a potent, selective, and reversible MMP-9 Inhibitor (IC₅₀...

Biovision | MIF-Antagonist, ISO-1 | 1895

Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS-...

Biovision | MIF antagonist, p425 | 2158

A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. Acts as an allosteric MIF (macrophage migration inhibitory factor) inhibitor. It occupies an interface of MIF trimers, leading to the loss of its...

Biovision | Metformin, Hydrochloride | 1691

An anti-diabetic agent. It reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein...

Biovision | L-JNK Peptide Inhibitor I | 7011

L-JNK Peptide Inhibitor competitively blocks the interaction between JNK and c-Jun, thereby inhibiting the signaling events downstream of JNK, like c-Jun, ATF-2 and ELK1 phosphorylation. To convert JIP-1/IB-1 into cell permeable inhibitors of JNK (JNKI1)...

Biovision | Leptomycin B | 1814

A potent, specific inhibitor of nuclear export signal (NES)-dependent protein export from the nucleus. It alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1(XPO1), a protein required for nuclear export of proteins containing a...

Biovision | Latrunculin B | 2182

A cell-permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Depolymerizes actin filaments (F-actin). Less potent than Latrunculin...

Biovision | Latrunculin A | 2181

A cell-permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin. Depolymerizes actin filaments (F-actin) and acts as a phagocytosis...

Biovision | Lactacystin (Synthetic) | 1709

Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities...

Biovision | Lactacystin (Natural) | 2434

Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities...

Biovision | EZSolution™ L-685,458 | 1713

Cell-permeable. A potent and selective γ-secretase inhibitor (IC₅₀ = 17 nM) .Displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC₅₀ values are 48 and...

Biovision | Jasplakinolide, jaspis johnstoni | 1689

A cell- permeable, non-fluorescent F-actin probe. Displays antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization, Jasplakinolide competes with phallotoxins for actin binding (Kd = 15 nM). It also enhances...

Biovision | Ingenol 3-angelate | 2593

Ingenol 3-angelate is a specific Protein Kinase C (PKC) activator and anti-cancer agent. Displays potent antileukemic activity mediated via the d isoform of PKC.Ingenol 3-angelate is a specific Protein Kinase C (PKC) activator and anti-cancer agent...

Biovision | Ilimaquinone | 2038

Cell-permeable. A marine sponge metabolite that acts as a cytoplasmic microtubule inhibitor. Induces a complete and reversible breakdown/disruption of Golgi membranes into smaller vesicular structures and blocks the association of the ADP-ribosylation...

Biovision | IC87114 | 1661

Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110δ (IC₅₀ = 60 nM). Inhibits p110α and p110β only at higher concentrations (>1 µM). IC87114 does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and...

Biovision | Hh Signaling Pathway Antagonist | 1659

Cell-permeable. A potent antagonist of the Hedgehog (Hh) signaling pathway (IC₅₀ = 70 nM).Hh Signaling Pathway Antagonist is a potent antagonist of the Hedgehog (Hh) signaling pathway (IC₅₀ = 70 nM).Biovision | 1659 | Hh Signaling Pathway Antagonist...

Biovision | GW 9662 | 1697

A Potent, selective and irreversible PPARɣ antagonist. Blocks the PPARɣ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.GW 9662 is a potent, selective and irreversible PPARɣ antagonist. Blocks the PPARɣ-induced...

Biovision | GST Inhibitor-2 (Ethacrynic acid)) | 1556

An effective Glutathione S-transferase(GST) inhibitor at 2-100 µMGST Inhibitor-2 (Ethacrynic acid) is an effective Glutathione S-transferase(GST) inhibitor at 2-100 µMBiovision | 1556 | GST Inhibitor-2 (Ethacrynic acid)) DataSheetAlternate Name/Synonyms:...

Biovision | GST Inhibitor-1 (Cibacron Blue 3G-A, Sodium Salt) | 1555R

Effective inhibition of Glutathione S-transferase (GST) at the concentration of 2-20 µM.GST Inhibitor-1 (Cibacron Blue 3G-A, Sodium Salt) is an effective inhibition of Glutathione S-transferase (GST) at the concentration of 2-20 µM.Biovision | 1555R |...

Biovision | GSK-3β Inhibitor, TWS119 | 1655

A potent inhibitor of GSK-3β (Glycogen synthase kinase-3β) (IC₅₀ = 30 nM). At 400 nM, TWS119 induces neurogenesis in murine embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.GSK-3β Inhibitor, TWS119 is a...

Biovision | Granzyme B Inhibitor Z-AAD-CH2Cl | 1128

A synthetic peptide that irreversibly inhibits granzyme B activity. The inhibitor is designed as a methyl ester to facilitate cell permeability.Z-AAD-CMK is a irreversible Granzyme B inhbitor.Biovision | 1128 | Granzyme B Inhibitor Z-AAD-CH2Cl...

Biovision | Granzyme B Inhibitor Ac-IEPD-CHO | 1119

A synthetic peptide that inhibits Granzyme B.Ac-IEPD-CHO is a synthetic peptide-based, reversible inhibitor of Granzyme B.Biovision | 1119 | Granzyme B Inhibitor Ac-IEPD-CHO DataSheetAlternate Name/Synonyms: Ac-IEPD-CHO, Granzyme B InhibitorAppearance:...

Biovision | Gö 6976 | 1711

Cell-permeable. A potent protein kinase C (PKC) inhibitor (IC₅₀ = 7.9 nM). In vitro, discriminates between Ca²⁺-dependent and -independent isoforms of PKC; selectively inhibits PKCα and PKCβ1 (IC₅₀ values are 2.3 and 6.2 nM respectively) but does not...

Biovision | GM 6001 | 1799

Cell-permeable. A broad spectrum matrix metalloprotease (MMP) inhibitor with Ki values of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM for MMPs -1, -2, -3, -7, -8, -9, -12, -14, and -26, respectively.GM6001 is a broad spectrum...

Biovision | Glycerol (50%), Sterile Solution | B1012

A sterile-filtered solution (50%) of Glycerol in de-ionized water.Glycerol (50%), Sterile Solution is a sterile-filtered solution of Glycerol (50%) in deionized waterBiovision | B1012 | Glycerol (50%), Sterile Solution DataSheetAlternate Name/Synonyms:...

Biovision | GGACK Dihydrochloride | 1847

Biovision | GGACK Dihydrochloride | 1847

Biovision | GF-627368X | B2029

GW-627368X is a potent and selective competitive antagonist of the prostanoid EP4 receptor with additional affinity at TP receptors (pKi values are 7.0 and 6.8 in competition radioligand bioassays). Displays antitumor activity.GW-627368X is a potent and...

Biovision | Fostriecin sodium | B1241

Fostriecin is a potent inhibitor of the serine/threonine protein phosphatases PP2A and PP4 with IC₅₀ value of 3.2 and 3 nM, respectively. It also displays weak inhibition of topoisomerase II having IC₅₀ of 40 μM and PP1 with IC₅₀ of 131 μM. Fostriecin...

Biovision | FK228 | 2447

A natural prodrug that inhibits Class I histone deacetylases (HDACs) (IC₅₀ values are: 36, 47, 510 and 14000 nM for HDAC1, HDAC2, HDAC4 and HDAC6, respectively). Displays potent anticancer activities.FK228 is a natural prodrug that inhibits Class I...

Biovision | FITC-VDVAD-FMK | 9498

FITC-VD(OMe)VAD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable caspase-2 inhibitor VD(OMe)VAD(OMe)-FMK that acts as an in situ marker for detection of caspase-2 in living cells. FITC-VD(OMe)VAD(OMe)-FMK is nontoxic, and...

Biovision | FITC-VAD-FMK | 9497

FITC-VAD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable pan-caspase inhibitor VAD(OMe)-FMK that acts as an in situ marker for detection of caspase in living cells. FITC-VAD(OMe)-FMK is nontoxic, and irreversibly binds to...

Biovision | FITC-LEHD-FMK | 9534

FITC-LE(OMe)HD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable caspase-9 inhibitor LE(OMe)HD(OMe)-FMK that acts as an in situ marker for detection of caspase-9 in living cells. FITC-LE(OMe)HD(OMe)-FMK is nontoxic, and...

Biovision | FITC-IETD-FMK | 9533

FITC-IE(OMe)TD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable caspase-8 inhibitor IE(OMe)TD(OMe)-FMK that acts as an in situ marker for detection of caspase-8 in living cells. FITC-IE(OMe)TD(OMe)-FMK is nontoxic, and...

Biovision | FITC-DEVD-FMK | 9499

FITC-D(OMe)E(OMe)VD(OMe)-FMK is a fluorescein isothiocyanate (FITC) conjugate of the cell- permeable caspase inhibitor D(OMe)E(OMe)VD(OMe)-FMK that acts as an in situ marker for detection of caspase-3 in living cells. FITC-D(OMe)E(OMe)VD(OMe)-FMK is...

Biovision | FAS Inhibitor, C75 | 1547

Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate...

Biovision | EZSolution™BRD-7552, Sterile-filtered | B2259

A 10 mM (5 mg in 703 μl), sterile-filtered solution of the PDX1 inducer BRD-7552 (Cat. No. B2258) in anhydrous DMSO.EZSolution™ BRD-7552 is a 10 mM (5 mg in 703 μl), sterile-filtered solution of the PDX1 inducer BRD-7552 (Cat. No. B2258) in anhydrous...

Biovision | EZSolution™ Y-27632, Sterile-Filtered | 1994

A 10 mM (3.20 mg in 1 ml) solution of the ROCK inhibitor Y-27632, Dihydrochloride (Cat. No. 1596) in deionized water.EZSolution™ Y-27632, Sterile-Filtered is a 10 mM (3.20 mg in 1 ml) solution of the ROCK inhibitor Y-27632, Dihydrochloride (Cat. No...

Biovision | EZSolution™ Y-27632 | 1784

A 10 mM (5 mg in 1550 µl) solution of Y-27632, Dihydrochloride (Cat. No. 1596-5) in deionized water.EZSolution™ Y-27632 is a 10 mM (5 mg in 1550 µl) solution of Y-27632, Dihydrochloride (Cat. No. 1596-5) in deionized water.Biovision | 1784 | EZSolution™...

Biovision | EZSolution™ WP1066 | 2546

A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and...

Biovision | EZSolution™ Wnt Antagonist, C59 | 9493

A 10 mM (1 mg in 264 µl) of potent Wnt signaling pathway inhibitor (Cat. No. 2063) in anhydrous DMSO.Wnt Antagonist, C59 is a potent Wnt signaling pathway inhibitor (IC₅₀ =

Biovision | EZSolution™ TWS-119, Sterile-filtered | B2237

A 10 mM (5.0 mg in 1.57 ml), sterile-filtered solution of the GSK-3β inhibitor TWS-119 (Cat. No. 1655) in anhydrous DMSO.EZSolution™ TWS-119 is a 10 mM (5.0 mg in 1.57 ml), sterile-filtered solution of the GSK-3β inhibitor TWS-119 (Cat. No. 1655) in...

Biovision | EZSolution™ TTNPB, Sterile-filtered | B2242

A 10 mM (5 mg in 1.43 ml), sterile-filtered solution of the RAR agonist TTNPB (Cat. No. 2776) in anhydrous DMSO.EZSolution™ TTNPB is a 10 mM (5 mg in 1.43 ml), sterile-filtered solution of the RAR agonist TTNPB (Cat. No. 2776) in anhydrous DMSO.Biovision...

Biovision | EZSolution™ Trichostatin A | 2271

A 10 mM (1 mg in 330 µl) of Trichostatin A (Cat. No. 1606-1) in anhydrous DMSO.Trichostatin A (TSA) is a potent, reversible inhibitor of histone deacetylase.Biovision | 2271 | EZSolution™ Trichostatin A DataSheetAlternate Name/Synonyms: TSA,...

Biovision | EZSolution™ Tozasertib | 1803

A 100 mM (25 mg in 538.1 µl) solution of Tozasertib (Cat. No. 1595-25) in anhydrous DMSO.EZSolution™ Tozasertib is a 100 mM (25 mg in 538.1 µl) solution of Tozasertib (Cat. No. 1595-25) in anhydrous DMSO.Biovision | 1803 | EZSolution™ Tozasertib...

Biovision | EZSolution™ Torin 2 | 2354

A potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 2.1 nM for mTORC1). Torin 2 displays 800-fold selectivity for mTOR over PI3K (cellular EC₅₀ values of 0.25 nM and 200 nM, respectively) and exhibits 100-fold binding selectivity relative to...

Biovision | EZSolution™ Torin 1 | 2353

A potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to...

Biovision | EZSolution™ Torcetrapib | 2533

Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels. However, in clinical trials, Torcetrapib displayed...

Biovision | EZSolution™ Thiazovivin, Sterile-Filtered | 1993

A 5 mM (1.56 mg in 1 ml), sterile-filtered solution of the enhancer of hESCs survival Thiazovivin (Cat. No. 1681) in anhydrous DMSO.EZSolution™ Thiazovivin, Sterile-Filtered is a 5 mM (1.56 mg in 1 ml), sterile-filtered solution of the enhancer of hESCs...

Biovision | EZSolution™ Thiazovivin | 1736

Cell-permeable. A 10 mM (1 mg in 321 µl) solution of Thiazovivin (Cat. No. 1681-1) in anhydrous DMSO.EZSolution™ Thiazovivin is a 10 mM (1 mg in 321 µl) solution of Thiazovivin (Cat. No. 1681-1) in anhydrous DMSO.Biovision | 1736 | EZSolution™...

Biovision | EZSolution™ TGR5 Receptor Agonist | 2538

Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells.EZSolution™ TGR5 receptor agonist is a 10 mM (5 mg in 1384 µl) solution...

Biovision | EZSolution™ Tetrahydrouridine | 2355

A 100 mM (25 mg in 1007 µl) sterile-filtered solution of Tetrahydrouridine (Cat. No.1671) in H₂O.Tetrahydrouridine is a competitive cytidine deaminase inhibitor and multidrug resistance modulator. Makes tumor cells more sensitive to radiation therapy...