Reagents

Biovision | EZSolution™ L-755,507 | B1873

A 10 mM (5.0 mg in 855 μl), sterile-filtered solution of the HDR (homology-directed repair) enhancer L-755,507 (Cat. No. B1116) in anhydrous DMSO.L-755,507 is a partial agonist of β3-adrenergic receptors (EC₅₀ = 0.43 nM). It displays >440-fold...

Biovision | EZSolution™ ISX9, Sterile-filtered | B2240

A 10 mM (5 mg in 2.13 ml), sterile-filtered solution of the neurogenesis promoter (Cat. No. 2563) in anhydrous DMSO.EZSolution™ ISX9 is a 10 mM (5 mg in 2.13 ml), sterile-filtered solution of the neurogenesis promoter (Cat. No. 2563) in anhydrous DMSO...

Biovision | EZSolution™ Ionomycin free acid | 2309

Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Ionomycin induces apoptosis in immature B cell lines...

Biovision | EZSolution™ I-CBP112, Sterile-filtered | B2256

A 10 mM (5 mg in 1067 μl), sterile-filtered solution of the CBP/EP300 bromodomain inhibitor I-CBP112 (Cat. No. 9405) in anhydrous DMSO.EZSolution™ is a 10 mM (5 mg in 1067 μl), sterile-filtered solution of the CBP/EP300 bromodomain inhibitor I-CBP112...

Biovision | EZSolution™ I-BET151, Sterile-filtered | B2252

A 5 mM (2 mg in 963 μl), sterile-filtered solution of the BET bromodomain inhibitor I-BET151 (Cat. No. 2220) in anhydrous DMSO.EZSolution™ I-BET151 is a 5 mM (2 mg in 963 μl), sterile-filtered solution of the BET bromodomain inhibitor I-BET151 (Cat. No...

Biovision | EZSolution™ Hygromycin B | 2590

A sterile-filtered solution (50 mg/ml) of the antibiotic Hygromycin B (Cat. No. 2589) in PBS buffer.EZSolution™ Hygromycin B is a sterile-filtered solution (50 mg/ml) of the antibiotic Hygromycin B (Cat. No. 2589) in PBS buffer.Biovision | 2590 |...

Biovision | EZSolution™ GW2580 | 2549

A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not...

Biovision | EZSolution™ GW 9662 | 9651

A 10 mM (5 mg in 1807 µl) of PPARγ antagonist GW9662 (Cat. No. 1697) in anhydrous DMSO.GW 9662 is a potent, selective and irreversible PPARɣ antagonist. Blocks the PPARɣ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM...

Biovision | EZSolution™ GSK'872 | B1501

A 10 mM (3.83 mg in 1 ml) of RIPK3 (receptor-interacting protein kinase-3) inhibitor (Cat. No. 2673) in anhydrous DMSO.GSK’872 is a potent, selective, and reversible RIPK3 (receptor-interacting protein kinase-3) inhibitor.Biovision | B1501 | EZSolution™...

Biovision | EZSolution™ GSK429286A | 2640

A 10 mM (1 mg in 231 µl) of the ROCK inhibitor GSK429286A (Cat. No. 2637) in anhydrous DMSO.GSK429286A is a potent and selective Rho-Kinase (ROCK) inhibitor (IC₅₀ = 14 and 63 nM for ROCK1 and ROCK2, respectively). ROCK inhibitors have been found to...

Biovision | EZSolution™ GSK343 | 2365

A 10 mM (1 mg in 185 µl) solution of the EZH2 inhibitor GSK343 (Cat. No. 2281) in anhydrous DMSO.GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC₅₀ = 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1...

Biovision | EZSolution™ GSK126 | 2366

A 10 mM (1 mg in 190 µl) solution of the EZH2 inhibitor GSK126 (Cat. No. 2282) in anhydrous DMSO.GSK126 is a potent, highly selective, S-adenosyl-methionine(SAM)-competitive, small-molecule inhibitor of EZH2 methyltransferase activity.Biovision | 2366 |...

Biovision | EZSolution™ Gö 6983 | 9540

A 10 mM (1 mg in 226 µl) of PKC inhibitor Gö 6983 (Cat. No.9539) in anhydrous DMSO.Gö 6983 is a broad-spectrum Protein Kinase C (PKC) inhibitor; inhibits several isoforms of protein kinase C with IC₅₀ values of 7, 7, 6, 10, 60, and 20,000 nM for PKCα,...

Biovision | EZSolution™ GM6001 | B2357

A 5 mM ( 1 mg in 520 µl) sterile-filtered solution of the broad spectrum MMP inhibitor GM-6001 (Cat. No. 1799) in anhydrous DMSOEZSolution™ GM-6001 is a 5 mM sterile-filtered solution of the broad spectrum MMP inhibitor GM-6001 (Cat. No. 1799) in...

Biovision | EZSolution™ Gemcitabine Hydrochloride | B2356

A 10 mM (5 mg in 1.67 ml), sterile-filtered solution of the anticancer agent Gemcitabine Hydrochloride (Cat. No. 1759) in deionized waterEZSolution™ Gemcitabine Hydrochloride is a 10 mM (5 mg in 1.67 ml), sterile-filtered solution of the anticancer agent...

Biovision | EZSolution™ Gefitinib | 2030

A 10 mM (5 mg in 1.12 ml) solution of Gefitinib (Cat. No. 1589-5) in anhydrous DMSO.EZSolution™ Gefitinib is a 10 mM (5 mg in 1.12 ml) solution of Gefitinib (Cat. No. 1589-5) in anhydrous DMSO.Biovision | 2030 | EZSolution™ Gefitinib DataSheetAlternate...

Biovision | EZSolution™ GDC-0449 | 2539

A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth.EZSolution™...

Biovision | EZSolution™ Forskolin | 2662

A 10 mM (5 mg in 1218 µl) solution of adenylyl cyclase activator Forskolin (Cat. No. 1531) in anhydrous DMSO.Forskolin is an activator of adenylate cyclase leading to an increase in the intracellular concentration of cAMP.Biovision | 2662 | EZSolution™...

Biovision | EZSolution™ Fasudil hydrochloride, Sterile-filtered | B2249

A 10 mM (5 mg in 1.53 ml), sterile-filtered solution of the Rho Kinase (ROCK) inhibitor Fasudil (Cat. No.1787) in water.EZSolution™ Fasudil hydrochloride is a 10 mM (5 mg in 1.53 ml), sterile-filtered solution of the Rho Kinase (ROCK) inhibitor Fasudil...

Biovision | EZSolution™ Erastin | B1502

A 10 mM (1 mg in 183 μl) of the antitumor agent Erastin (Cat. No. 2231) in anhydrous DMSO.Erastin is a selective antitumor agent that displays greater lethality in human tumour cells harbouring mutations in the oncogenes HRAS, KRAS or BRAFBiovision |...

Biovision | EZSolution™ EPZ-6438 | 2428

A 10 mM (5 mg in 874 µl) solution of the of the EZH2 inhibitor EPZ6438 (Cat. No.2383) in anhydrous DMSO.EPZ-6438 is a potent and selective inhibitor of histone methyltransferase EZH2.Biovision | 2428 | EZSolution™ EPZ-6438 DataSheetAlternate...

Biovision | EZSolution™ EPZ-5676 | 2427

A 10 mM (1 mg in 178 µl) solution of the of DOT1L methyltransferase inhibitor EPZ5676 (Cat. No. 2382) in anhydrous DMSO.EPZ-5676 is a potent and selective inhibitor of DOT1L methyltransferase (Ki = 80 pM).Biovision | 2427 | EZSolution™ EPZ-5676...

Biovision | EZSolution™ EPZ005687 | 2375

A 10 mM (2 mg in 370 µl) solution of the EZH2 inhibitor EPZ-005687 (Cat. No. 2364) in anhydrous DMSO.A potent and selective inhibitor of histone lysine N-methyltransferase EZH2 (Ki = 24 nM).Biovision | 2375 | EZSolution™ EPZ005687 DataSheetAlternate...

Biovision | EZSolution™ DPQ | 2866

A 10 mM (5 mg in 1653 µl) of the PARP inhibitor DPQ (Cat. No. 1899) in anhydrous DMSO.DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.Biovision | 2866 | EZSolution™ DPQ DataSheetAlternate Name/Synonyms:...

Biovision | EZSolution™ Dorsomorphin | 2547

Cell-permeable. A potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 µM ATP and no AMP). Does not affect the activity on several structurally related kinases including...

Biovision | EZSolution™ Doramapimod, Sterile-filtered | B2254

A 10 mM (5 mg in 948 μl), sterile-filtered solution of the p38 MAP kinase inhibitor Doramapimod (Cat. No. 1954) in anhydrous DMSO.EZSolution™ is a 10 mM (5 mg in 948 μl), sterile-filtered solution of the p38 MAP kinase inhibitor Doramapimod (Cat. No...

Biovision | EZSolution™ Digitonin | 2082

A 5% solution of the non-ionic detergent Digitonin (Cat.# 2081) in deionized water.EZSolution™ Digitonin is a 5% solution of the non-ionic detergent Digitonin (Cat.# 2081) in deionized water.Biovision | 2082 | EZSolution™ Digitonin DataSheetAlternate...

Biovision | EZSolution™ Dasatinib | 2029

A 100 mM (25 mg in 512 µl) solution of Dasatinib (Cat. No. 1586-25) in anhydrous DMSO.EZSolution™ Dasatinib is a 100 mM (25 mg in 512 µl) solution of Dasatinib (Cat. No. 1586-25) in anhydrous DMSO.Biovision | 2029 | EZSolution™ Dasatinib...

Biovision | EZSolution™ DAPT | 2663

A 10 mM (5 mg in 1156 µl) solution of γ-secretase inhibitor DAPT (Cat. No.1855) in anhydrous DMSO.DAPT is a potent inhibitor of γ-secretase (IC₅₀ = 115 nM for total β-amyloid, IC₅₀ = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and...

Biovision | EZSolution™ Cyclopamine | 2545

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins...

Biovision | EZSolution™ Chloramphenicol, Sterile-Filtered | 2500

A solution (34 mg/ml, 0.2 µM sterile filtered) of Chloramphenicol (Cat. No. 2486) in 100% Ethanol. Suitable for cell culture applications.Chloramphenicol is a bacteriostatic antibiotic that inhibits bacterial protein synthesis. Displays a broad spectrum...

Biovision | EZSolution™ CHIR99021, Sterile-Filtered | 1991

A 10 mM (4.65 mg in 1 ml), sterile-filtered solution of the GSK-3β inhibitor CHIR99021 (Cat. No. 1677) in anhydrous DMSO.EZSolution™ CHIR99021, Sterile-Filtered is a 10 mM (4.65 mg in 1 ml), sterile-filtered solution of the GSK-3β inhibitor CHIR99021...

Biovision | EZSolution™ CHIR99021 trihydrochloride, Sterile-Filtered | B1219

A 10 mM (5.74 mg in 1 ml), sterile-filtered solution of the GSK-3β inhibitor CHIR99021 trihydrochloride (Cat. No. B1199) in anhydrous DMSOA 10 mM (5.74 mg in 1 ml), sterile-filtered solution of the GSK-3β inhibitor CHIR99021 trihydrochloride (Cat. No...

Biovision | EZSolution™ CHIR99021 | 1748

A 10 mM (5 mg in 1075 µl) solution of CHIR99021 (Cat. No. 1677-5) in anhydrous DMSO.EZSolution™ CHIR99021 is a 10 mM (5 mg in 1075 µl) solution of CHIR99021 (Cat. No. 1677-5) in anhydrous DMSO.Biovision | 1748 | EZSolution™ CHIR99021 DataSheetAlternate...

Biovision | Ezsolution™ CHIR-98014 | 2639

A 10 mM (1 mg in 206 µl) of the GSK-3 inhibitor CHIR-98014 (Cat. No. 2595) in anhydrous DMSO.CHIR-98014 is a potent, selective and ATP-competitive inhibitor of GSK3α and GSK3β (IC₅₀ = 0.65 and 0.58 nM, respectively). In addition, CHIR-98014 displays 500...

Biovision | EZSolution™ Calpain Inhibitor, Z-LLY-FMK | 1125

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M⁻¹s⁻¹). Also acts as an inhibitor of cathepsin L (k₂= 680,000 M⁻¹s⁻¹).Z-LLY-FMK is a potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M⁻¹s⁻¹)...

Biovision | EZSolution™ Bromosporine, Sterile-filtered | B2255

A 10 mM (5 mg in 1236 μl), sterile-filtered solution of the bromodomain inhibitor Bromosporine (Cat. No. 2652) in anhydrous DMSO.EZSolution™ is a 10 mM (5 mg in 1236 μl), sterile-filtered solution of the bromodomain inhibitor Bromosporine (Cat. No. 2652)...

Biovision | EZSolution™ Brefeldin A | B1872

A 10 mM (5.0 mg in 1.78 ml), sterile-filtered solution of the HDR (homology-directed repair) enhancer Brefeldin A (Cat. No. 1560) in anhydrous DMSO.Brefeldin A has been shown to induce apoptosis in human tumor cells through caspase activation. It has...

Biovision | EZSolution™ BMS-299897, Sterile-filtered | B2243

A 10 mM (5 mg in 977 μl), sterile-filtered solution of the gamma- secretase inhibitor BMS-299897 (Cat. No. 9606) in anhydrous DMSO.EZSolution™ BMS-299897 is a 10 mM (5 mg in 977 μl), sterile-filtered solution of the gamma-secretase inhibitor BMS-299897...

Biovision | EZSolution™ Blasticidin S Hydrochloride, Sterile-Filtered | 2805

A sterile-filtered aqueous solution (10 mg/ml) of the antibiotic Blasticidin HCl (Cat.No. 1859) in HEPES (20 mM), pH 7.5.Blasticidin S is a peptide nucleoside antibiotic that is used as a selection agent for transformed cells that contain the resistance...

Biovision | EZSolution™ BIX 01294 | 2661

A 10 mM (5 mg in 1019 µl) solution of the HMTase inhibitor BIX01294 (Cat. No. 1678) in anhydrous DMSO.BIX01294 selectively impairs the G9a histone lysine methyltransferase (HMTase) and the generation of H3K9me2 in vitro. BIX-01294 enables neural...

Biovision | EZSolution™ BAY 58-2667 Hydrochloride | 9494

A 10 mM (1 mg in 166 µl) of heme-independent soluble guanylyl cyclase activator BAY 58-2667 hydrochloride (Cat. No. 2027) in anhydrous DMSO.BAY 58-2667 Hydrochloride is a nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator...

Biovision | EZSolution™ BAY 43-9006 (Tosylate) | 2031

A 100 mM (25 mg in 392 μl) solution of BAY 43-9006 (Cat. No.1594-25) in anhydrous DMSO.EZSolution™ BAY 43-9006 is a 100 mM (25 mg in 392 μl) solution of BAY 43-9006 (Cat. No.1594-25) in anhydrous DMSO.Biovision | 2031 | EZSolution™ BAY 43-9006 (Tosylate)...

Biovision | EZSolution™ Batimastat | 2540

Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts...

Biovision | EZSolution™ Anacetrapib | 2531

Anacetrapib is a potent inhibitor of the cholesteryl ester transfer protein (CETP)-dependent transfer of cholesteryl ester (CE) (IC₅₀ = 17 ± 4.8 nM); it significantly raises HDL cholesterol levels in humans.EZSolution™ Anacetrapib is a 10 mM (1 mg in 157...

Biovision | EZSolution™ Ampicillin sodium, Sterile-Filtered | 2499

Ampicillin sodium is a β-lactam antibiotic structurally related to penicillin. Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Ampicillin sodium can be used as a selective agent...

Biovision | EZSolution™ AICAR | 2344

A cell- permeable activator of AMP-activated protein kinase (AMPK), a metabolic sensor involved in both cellular and whole body energy homeostasis. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent...

Biovision | EZSolution™ A83-01, Sterile-Filtered | 1989

A 5 mM (2.1 mg in 1 ml), sterile-filtered solution of the ALK5 inhibitor A83-01(Cat. No. 1725) in anhydrous DMSO.EZSolution™ A83-01, Sterile-Filtered is a 5 mM (2.1 mg in 1 ml), sterile-filtered solution of the ALK5 inhibitor A83-01(Cat. No. 1725) in...

Biovision | EZSolution™ 8-Br-cAMP, Sterile-filtered | B2257

A 10 mM (5 mg in 1163 μl), sterile-filtered solution of the cAMP analog, 8-Br-cAMP (Cat. No. 1837) in anhydrous DMSO.EZSolution™ is a 10 mM (5 mg in 1163 μl), sterile-filtered solution of the cAMP analog, 8-Br-cAMP (Cat. No. 1837) in anhydrous DMSO...

Biovision | EZSolution™ 5-Fluoroorotic acid monohydrate (5-FOA) | 2797

5-Fluoroorotic Acid (5-FOA) is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate (OMP) decarboxylase. 5-FOA is toxic to yeast cells that can synthesize the enzyme orotidine-5’-phosphate...

Biovision | EZSolution™ 3-Deazaneplanocin A | 2409

A 10 mM (1 mg in 381 µl) solution of the EZH2 inhibitor 3-Deazaneplanocin (Cat. No. 2060) in anhydrous DMSO.3-Deazaneplanocin is a lysine methyltransferase EZH2 (KMT63) inhibitor.Biovision | 2409 | EZSolution™ 3-Deazaneplanocin A DataSheetAlternate...

Biovision | EZSolution™ 17-AAG | 9495

A 10 mM (1 mg in 171 µl) of Hsp90 inhibitor 17-AAG (Cat. No.1774) in anhydrous DMSO.17-AAG is a semi-synthetic derivative of Geldanamycin (Cat. No. 1564-1,5) that displays greater stability and lower in vivo toxicity compared to Geldanamycin. Binds to...