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Biovision

  • CC-90003

    Biovision | CC-90003 | B2419

    CC-90003 is a potent extracellular signal-regulated kinases (ERK1/2) inhibitor. CC-90003 inhibits ERK activity, and prevents the activation of ERK-mediated signal transduction pathways. This results...

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  • WM-1119

    Biovision | WM-1119 | B2418

    WM-1119 is a potent, reversible, and competitive inhibitor of lysine acetyltransferase KAT6A ( Kd = 2 nM). Displays 1,100-fold and 250-fold selectivity over KAT5 and KAT7, respectively; causes cell...

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  • Silvestrol

    Biovision | Silvestrol | B2417

    Silvestrol is a natural product isolated from the fruits and twigs of Aglaia foveolata. Acts as a eukaryotic translation initiation factor 4A (eIF4A) inhibitor. Also displays broad-spectrum antiviral...

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  • DTT

    Biovision | DTT | B2409

    A useful reagent for maintaining SH groups in reduced state; quantitatively reduces disulfides. DTT is effective in sample buffers for reducing protein disulfide bonds prior to SDS-PAGE.DTT is a...

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  • LOXO-195

    Biovision | LOXO-195 | B2226

    LOXO-195 is a potent and selective TRK (tropomyosin-related-kinase) inhibitor, with potential anticancer activity. LOXO-195 specifically targets and binds to TRK, including the fusion proteins...

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  • Dalbavancin

    Biovision | Dalbavancin | B2099

    Dalbavancin is a second-generation lipoglycopeptide antibiotic that is active against gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), and minimum inhibitory...

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  • GSK-1838705A

    Biovision | GSK-1838705A | B2026

    GSK-1838705A is a potent small-molecule kinase inhibitor that inhibits IGF-IR and IR (insulin receptor) with IC₅₀s of 2.0 and 1.6 nM, respectively. It also inhibits anaplastic lymphoma kinase (ALK)...

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  • Ipragliflozin

    Biovision | Ipragliflozin | B1926

    Ipragliflozin is a potent inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC₅₀ = 7.4 nM for human SGLT2 in vitro) that increases excretion of glucose.Iipragliflozin is found to promote...

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  • A-1210477

    Biovision | A-1210477 | B1826

    A-1210477 is a potent MCL-1 inhibitor (Ki = 0.45 nM in TR-FRET-binding assays). Acts as a weak inhibitor of BCL-2 (Ki = 0.132 μM) and BCL-XL(Ki>0.660 μM).A-1210477 is a potent MCL-1 inhibitor (Ki = 0...

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  • PKI-402

    Biovision | PKI-402 | B1727

    PKI-402 is a potent dual inhibitor of PI3K/mTOR with IC50 values of 2 nM/7 nM/16 nM/14 nM and 3 nM for PI3Kα/β/γ/δ and mTOR, respectively. PKI-402 is a potent dual inhibitor of PI3K/mTOR with IC50...

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  • CZ415

    Biovision | CZ415 | B1726

    CZ415 is a potent and highly selective mTOR inhibitor.CZ415 is a potent and highly selective mTOR inhibitor.Biovision | B1726 | CZ415 DataSheetAlternate Name/Synonyms: CZ415; CZ 415; CZ-415;...

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  • Brivanib Alaninate

    Biovision | Brivanib Alaninate | B1326

    Brivanib Alaninate is an ATP-competitive inhibitor of VEGFR2 with (IC₅₀ = 25 nM). Displays potent antineoplastic activity.Brivanib Alaninate is an ATP-competitive inhibitor of VEGFR2 with (IC₅₀ = 25...

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  • Azithromycin

    Biovision | Azithromycin | B1226

    Azithromycin is a macrolide antibiotic that inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram positive and negative bacteria. In vivo activity shows improved...

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  • Trifluorothymidine

    Biovision | Trifluorothymidine | B1126

    Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking...

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  • PF-3274167

    Biovision | PF-3274167 | B1026

    PF-3274167 is a potent, selective, and high-affinity non-peptide oxytocin receptor (OTR) antagonist (Ki of 9.5 nM).PF-3274167 is a potent, selective, and high-affinity non-peptide oxytocin receptor...

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  • Raptinal

    Biovision | Raptinal | 9626

    Raptinal is a rapid inducer of apoptosis. Consistent with apoptotic morphological changes, U-937 cells treated with 10 μM Raptinal displays modest (at 30 min) and extensive (at 60 min) blebbing...

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  • Posaconazole

    Biovision | Posaconazole | 9526

    Posaconazole is a broad-spectrum, second-generation triazole compound that displays antifungal activity. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme...

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  • J147

    Biovision | J147 | 9426

    J 147 is a potent neuroprotective and neurotrophic compound that protects against neurotoxicity in cortical neurons in vitro (EC₅₀ = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases...

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  • CL-387785

    Biovision | CL-387785 | 2826

    CL-387785 is an irreversible inhibitor of EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC₅₀ = 250-490 pM) and blocks EGF-mediated...

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  • DMXAA

    Biovision | DMXAA | 2804

    DMXAA acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon...

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  • SGI-1027

    Biovision | SGI-1027 | 2726

    SGI-1027 is a selective DNA methyltransferase (DNMT) inhibitor. Inhibits DNMT1, DNMT3A, and DNMT3B with IC₅₀ values of 6, 8, and 7.5 µM, respectively. Treatment of different cancer cell lines with...

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  • STA-21

    Biovision | STA-21 | 2626

    STA-21 is a natural antibiotic that acts as a selective STAT3 inhibitor. It inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM. It blocks the growth...

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  • Hypericin

    Biovision | Hypericin | 2526

    Isolated from Hypericum perforatum, St. John’s Wort. Hypericin has been shown to display antiviral and antiretroviral activity. A potent and selective inhibitor of protein kinase C (IC₅₀ = 3.4 µM)...

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  • Phytosphingosine

    Biovision | Phytosphingosine | 2426

    Phytosphingosine is a phospholipid structurally similar to Sphingosine (Cat. No. 2425). The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human...

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  • BML-278

    Biovision | BML-278 | 2379

    Cell-permeable. A structurally novel activator of SIRT1 (EC₅₀ = 1 µM). Displays selectivity over SIRT2 and 3 (EC₅₀ = 25 and 50 µM respectively).BML-278 is a structurally novel activator of SIRT1...

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  • Sulfo-NHS-LC-Biotin

    Biovision | Sulfo-NHS-LC-Biotin | 2326

    KEY FEATURES: • Amine-reactive; has a spacer with arm length of 22.4 Å which helps to minimize steric hindrance to biotin labeling • More water-soluble than the corresponding NHS compound without...

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  • IOX1

    Biovision | IOX1 | 2266

    Cell-permeable. A histone demethylase (HDM) JMJD nhibitor. Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC₅₀s = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 µM for JMJD3, JMJD1A,...

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  • Xanthohumol

    Biovision | Xanthohumol | 2258

    Cell-permeable. A bioactive flavonoid antioxidant found in the flowering hops plant. Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome...

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  • Temozolomide

    Biovision | Temozolomide | 2226

    A DNA methylating agent. A second-generation imidazotetrazine prodrug that undergoes spontaneous conversion under physiological conditions to the active alkylating agent MTIC...

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  • Garcinol

    Biovision | Garcinol | 2088

    Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50 = 7 µM) and PCAF (IC50 = 5 µM) both in...

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  • Piceatannol

    Biovision | Piceatannol | 2072

    A natural stilbene and an analogue of Resveratrol (Cat. No. 1758-100, 500). Besides antioxidative effects, piceatannol exhibits potential anticancer properties as shown by its ability to suppress...

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  • Sirtinol

    Biovision | Sirtinol | 2062

    Cell-permeable. A selective sirtuin deacetylase inhibitor with IC50 values of 38, 68 and 131 μM for SIRT2, Sir2p and SIRT1 respectively. Sirtinol has no effect on HDAC1 activity. Sirtinol inhibits...

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  • WST-8

    Biovision | WST-8 | 2049

    WST-8 is a next generation tetrazolium reagent that serves as a sensitive chromogenic indicator for NADH. It is reduced by NADH at neutral pHs in the presence of 1-methoxy PMS to produce the...

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  • 5-Azacytidine

    Biovision | 5-Azacytidine | 1854

    A potent growth inhibitor and cytotoxic agent; a potent DNA methyltransferase inhibitor. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to...

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  • Niclosamide

    Biovision | Niclosamide | 1826

    A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer...

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  • Resveratrol

    Biovision | Resveratrol | 1758

    A phytoalexin found in the skin of red grapes and as a constituent in red wine. Displays anti-inflammatory, and anti-tumor properties. Acts as an antioxidant and specific inihibitor of...

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  • JK 184

    Biovision | JK 184 | 1726

    An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC₅₀ = 210 nM).JK...

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  • IBMX

    Biovision | IBMX | 1714

    Cell-permeable. A nonspecific phosphodiesterase inhibitor (IC₅₀ values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively).IBMX is a nonspecific phosphodiesterase inhibitor...

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  • BEZ235 (NVP-BEZ235)

    Biovision | BEZ235 (NVP-BEZ235) | 1626

    Orally active PI-3 kinase inhibitor; Dual PI3K/mTOR inhibition; BEZ235 showed high target specificity and demonstrated anti-proliferative activity against tumor cell lines in animal models of cancer...

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  • Trichostatin A

    Biovision | Trichostatin A | 1606

    Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6- methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types,...

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  • Apicidin

    Biovision | Apicidin | 1601

    A potent, cell permeable inhibitor of histone deacetylase (IC₅₀ = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC₅₀ = 50 – 100 nM) and induces the transcriptional...

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  • G418 Sulfate

    Biovision | G418 Sulfate | 1557

    Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely...

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