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Biovision | Ac-IEPD-AFC | B2526

Ac-IEPD-AFC is a useful fluorogenic substrate for the detection of Granzyme B. Granzyme B activity can be quantified by fluorescent detection of free AFC that has an excitation maximum at 400 nm and...

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Biovision | Clemastine Fumarate | B2525

Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM); also displays high affinity for muscarinic receptors (Ki = 16 nM). Also acts as a positive allosteric modulator of...

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Biovision | LTURM-34 | B2524

LTURM-34 is a potent DNA-PK inhibitor (IC₅₀ = 34 nM). Displays 170-fold selectivity for DNA-PK over PI3-K. Attenuates proliferation of a wide range of tumor cell lines in vitro.LTURM-34 is a potent...

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Biovision | PP121 | B2523

PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 inhibits both tyrosine kinases and PI3-Ks but not serine-threonine kinases. It potently inhibits p110α, p110β, p110γ, p110δ,...

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Biovision | NU-7026 | B2522

NU-7026 is a potent DNA-PK inhibitor (IC₅₀ of 0.23 μM); displays 60-fold selectivity for DNA-PK than PI3K and inactive against both ATM and ATR.NU-7026 is a potent DNA-PK inhibitor (IC₅₀ of 0.23 μM);...

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Biovision | AM-679 | B2521

AM-679 is a potent 5-lipoxygenase-activating protein (FLAP) inhibitor with IC₅₀s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.AM-679 is a potent 5-lipoxygenase-activating protein...

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Biovision | MK-591, Free acid | B2520

MK-0591 is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and platelet...

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Biovision | MK-591 sodium salt | B2519

MK-0591 sodium is a potent and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in FLAP binding assay; it displays no inhibitory effect on 15-lipoxygenase and...

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Biovision | GSK-2190915 sodium salt | B2518

GSK-2190915 sodium is a potent and selective FLAP (5-Lipoxygenase-activating protein) inhibitor (IC₅₀ of 2.6 nM); displays good selectivity over CYP3A4, 2C9, and 2D6. In an acute inflammation...

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Biovision | MK-886 | B2517

MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes (IC₅₀ of 2.5...

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Biovision | SPHINX31 | B2516

SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) IC₅₀ = 5.9 nM). It displays selectivity for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31...

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Biovision | PFK-158 | B2515

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC₅₀ = 137 nM for human recombinant PFKFB3). Upon administration, PFK-158 binds to and inhibits the activity...

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Biovision | CH7057288 | B2514

CH7057288 as a potent and selective TRK (tropomyosin receptor kinase) inhibitor that may be useful in inhibiting TRK fusion-positive cancer cell growth. CH7057288 shows selective inhibitory activity...

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Biovision | AZD-3229 | B2513

AZD3229 is a potent, pan-KIT mutant inhibitor that displays single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). It also inhibits PDGFR...

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Biovision | Zanubrutinib | B2512

Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor; displaysmuch more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib...

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Biovision | PLX-51107 | B2511

PLX-51107 is a potent inhibitor of the bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon administration, PLX51107 binds to the acetylated lysine recognition motifs...

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Biovision | SAR-125844 | B2510

SAR-125844 is a potent, selective, reversible and ATP-competitive c-MET inhibitor, with an IC₅₀ of 4.2 nM. Displays inhibition of MET autophosphorylation in cell-based assays. Upon intravenous...

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Biovision | CPI-1205 | B2509

CPI-1205 is a highly potent (biochemical IC₅₀ = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of the histone lysine methyltransferase EZH2 (biochemical IC₅₀ = 0.002 μM, cellular EC₅₀ =...

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Biovision | MEDICA 16 | B2508

MEDICA 16 is a GPR40 agonist; displays selectivity for FFA1 (GPR40) over GPR120. Exhibits hypolipidemic and antidiabetogenic effects in the rat. Also inhibits ATP citrate lyase.MEDICA 16 is a GPR40...

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Biovision | SB-204490 | B2507

SB-204490 is a potent and specific ATP citrate lyase (ACLY) inhibitor. Prodrug of SB-201076. Inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells.SB-204490 is a...

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Biovision | Namodenoson | B2506

Namodenoson (CF-102) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectivelyNamodenoson (CF-102) is a selective A3...

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Biovision | CEP-40783 | B2505

CEP-40783 (RDX-106) is a potent and selective inhibitor of AXL and c-Met with IC₅₀ values of 7 nM and 12 nM, respectively. In AXL-transfected 293GT cells, CEP-40783 was 27-fold more active compared...

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Biovision | CEP-37440 | B2504

CEP-37440 is a potent and selective dual FAK/ALK inhibitor with IC₅₀ s of 2.3 nM (FAK) and 120 nM (ALK cellular IC₅₀ in 75% human plasma). The inhibition leads to disruption of ALK- and FAK-mediated...

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Biovision | CEP-28122 | B2503

CEP-28122 is a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). Displays antitumor activity in experimental models of human cancers.CEP-28122...

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Biovision | CCT-251921 | B2502

CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC₅₀, CDK8 = 2.3 nM; CDK19 = 2.6 nM).CCT-251921 is a potent, selective,...

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Biovision | CCT-251545 | B2501

CCT-251545 is a potent Wnt signaling inhibitor (IC₅₀ = 5 nM). It is a selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and...

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Biovision | CCT-196969 | B2500

CCT-196969 is a pan-Raf inhibitor, which inhibits B-Raf, BRafV600E and CRAF with IC₅₀s of 0.1, 0.04, and 0.01 μM, respectively. It is selective for RAFs, Src, LCK, and MAPKs in a panel of 63 kinases...

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Biovision | CC-115 | B2499

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and displays effective reduction of murine...

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Biovision | XMU-MP-1 | B2498

XMU-MP-1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC₅₀ values are 38.1 and 71.1 nM for MST2 and MST1, respectively). It is selective for MST1...

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Biovision | DIM-C-pPhCO2Me | B2497

DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist that displays antineoplastic activity.DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist that displays antineoplastic activity...

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Biovision | IDO-IN-2 | B2496

IDO-IN-2 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ = 0.068 µM).IDO-IN-2 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC₅₀ = 0.068 µM).Biovision | B2496 | IDO-IN-2...

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Biovision | 4μ8C | B2495

4µ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC₅₀ = 60 nM). It blocks substrate access to the active site of IRE1α and inactivates IRE1α-mediated mRNA degradation. Displays...

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Biovision | CAY10566 | B2494

CAY10566 is a potent and selective stearoyl-CoA desaturase (SCD) inhibitor (IC₅₀ values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.CAY10566 is a potent and selective...

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Biovision | Marizomib | B2493

Marizomib (Salinosporamide A) is a potent, reversible, broad-spectrum, brain-penetrant proteasome inhibitor, that displays antitumor activity in vitro and in vivo.Marizomib (Salinosporamide A) is a...

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Biovision | EZSolution™ Carfilzomib | B2491

A 10 mM (5 mg in 695 µl) of the potent proteasome inhibitor Carfilzomib (Cat. No. 2385) in anhydrous DMSO.Carfilzomib (PR-171) is a next generation, irreversible and selective inhibitor of the...

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Biovision | EZSolution™ AZD-9291 (Osimertinib) | B2490

A 10 mM (5 mg in 1.0 ml) of the potent EGFR inhibitor AZD-9291 (Osimertinib) (Cat. No. 2674) in anhydrous DMSO.AZD-9291(Osimertinib) is a potent, third generation, mutant-selective EGFR tyrosine...

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Biovision | EZSolution™ Cobimetinib | B2489

A 10 mM (5 mg in 941 µl) of the potent MEK inhibitor Cobimetinib (Cat. No. B1689) in anhydrous DMSO.Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein...

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Biovision | EZSolution™ Ixazomib | B2488

A 10 mM (5 mg in 1.38 ml) of the potent proteasome inhibitor Ixazomib (Cat. No. B2384) in anhydrous DMSO.Ixazomib (MLN-2238), is a potent proteasome inhibitor (PI) with potential antineoplastic...

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Biovision | EZSolution™ Fedratinib (TG101348) | B2487

A 10 mM (5 mg in 953 µl) of the potent JAK2 inhibitor TG101348 (Fedratinib) in anhydrous DMSO.TG101348 is a potent, and selective inhibitor of JAK2 (IC₅₀ = 3 nM). It has a 35- and 334-fold...

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Biovision | EZSolution™ABT-494 (Upadacitinib) | B2486

A 10 mM (5 mg in 1.31 ml) solution of the potent JAK1 inhibitor ABT-494 (Upadacitinib) in anhydrous DMSO.ABT-494 (Upadacitinib) is a potent and selective Janus kinase JAK-1 inhibitor (IC₅₀ = 43 nM)...

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Biovision | EZSolution™ Pacritinib | B2485

A 10 mM (1 mg in 212 µl) of the potent JAK2/FLT3 inhibitor Pacritinib (SB1518) (Cat. No. 2450) in anhydrous DMSO.A potent JAK2/FLT3 inhibitor. Displays equipotent activity against JAK2 (I₅₀ = 23 nM)...

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Biovision | EZSolution™ Cyt387 | B2484

A 10 mM (5 mg in 1.21 ml) of the JAK1 and JAK2 inhibitor Cyt387 (Momelotinib) (Cat. No. 2316) in anhydrous DMSO.Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ values of 11 nM and...

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Biovision | EZSolution™ LY-2784544 | B2483

A 10 mM (5 mg in 1064 µl) solution of the potent JAK2 inhibitor LY-2784544 (Gandotinib) (Cat. No. B1914) in anhydrous DMSO.LY2784544 (Gandotinib) is a potent, selective and ATP-competitive JAK2...

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Biovision | EZSolution™ Cerdulatinib | B2482

A 10 mM (5 mg in 1.12 ml) solution of the potent Syk and JAK inhibitor Cerdulatinib (Cat. No. 2803) in anhydrous DMSO.Cerdulatinib is a novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK)...

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Biovision | EZSolution™ Filgotinib | B2481

A 10 mM (5 mg in 1.18 ml) solution of the potent JAK1 inhibitor Filgotinib (Cat. No. 2871) in anhydrous DMSO.Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold...

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Biovision | EZSolution™ Baricitinib | B2480

A 10 mM (5 mg in 1.35 ml) of the JAK1 and JAK2 inhibitor Baricitinib (Cat. No. 2842) in anhydrous DMSO.Baricitinib is a selective JAK1 and JAK2 inhibitor with IC₅₀ values of 5.9 nM and 5.7 nM,...

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Biovision | EZSolution™ PF-03394197 | B2479

A 10 mM (5 mg in 1.48 ml) solution of the JAK inhibitor PF-03394197 (Oclacitinib) in anhydrous DMSO.PF-03394197 (Oclacitinib) is potent and selective Janus kinase (JAK) inhibitor. It inhibits JAK...

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Biovision | EZSolution™ CP-690550 | B2478

A 10 mM (5 mg in 1.60 ml) solution of the potent JAK3 inhibitor CP-690550 (Cat. No. 1622) in anhydrous DMSO.A Janus Kinase 3 (JAK3) inhibitor. Displays greater antiproliferative and pro-apoptotic...

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Biovision | EZSolution™ Ruxolitinib | B2477

A 10 mM (5 mg in 1.63 ml) solution of the potent JAK inhibitor Ruxolitinib (Cat. No. 2139) in anhydrous DMSO.Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with IC₅₀'s of 2.7 and...

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Biovision | Oosporein | B2476

Oosporein is a di-symmetric cyclohexadienedione produced by several species of fungi. Displays toxic effects on humans as well as animal health. Also acts as an ATPase inhibitor.Oosporein is a...

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Biovision | CHZ868 | B2475

CHZ868 is a potent and selective type II JAK2 inhibitor (IC₅₀ = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays...

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Biovision | Peficitinib | B2474

Peficitinib is a potent JAK inhibitor, with IC₅₀s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC₅₀ =...

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