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Biovision

  • NMS-1286937

    Biovision | NMS-1286937 | B2636

    NMS-1286937 a potent, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC₅₀ = 2 nM) with potential antineoplastic activity. It selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest...

    $949 - $2,898
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  • DAPPD

    Biovision | DAPPD | B2635

    DAPPD is an antineuroinflammatory agent. DAPPD regulates microglial function, suppresses neuroinflammation, fosters cerebral Aβ clearance, and attenuates cognitive deficits in AD transgenic mouse...

    $665 - $1,120
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  • PF-3758309

    Biovision | PF-3758309 | B2634

    PF-3758309 is a potent small molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth...

    $949 - $2,898
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  • ML-228

    Biovision | ML-228 | B2633

    ML-228 is an activator of the Hypoxia Inducible Factor (HIF) signaling pathway, as demonstrated by HIF response element (HRE) reporter assay (EC50 = 1.2 µM), HIF-1α nuclear translocation assay (EC50...

    $718 - $1,866
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  • Dimedone

    Biovision | Dimedone | B2632

    Dimedone displays many biological properties such as anticarcinogenic, antioxidant, antihistaminic, and anticoagulant.Dimedone displays many biological properties such as anticarcinogenic,...

    $606 - $837
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  • Sucralfate

    Biovision | Sucralfate | B2620

    Sucralfate is a basic aluminum sucrose sulfate complex that displays gastroprotective activity. It inhibits rat pepsin in a concentration-dependent manner and pepsin activity in isolated human...

    $665 - $1,180
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  • Qstatin

    Biovision | Qstatin | B2618

    Qstatin is a potent, and selective Vibrio QS inhibitor which affects Vibrio harveyi LuxR homologues, the well-conserved master transcriptional regulators for QS in Vibrio species. QStatin binds...

    $837 - $2,440
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  • Paquinimod

    Biovision | Paquinimod | B2617

    Paquinimod is a small molecule quinoline-3-carboxamide derivative that acts as a S100A9 inhibitor. It targets the S100A9 protein and disrupts its binding to the pro-inflammatory receptors, Receptor...

    $1,411 - $4,732
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  • Astilbin

    Biovision | Astilbin | B2616

    Astilbin is a flavonoid that displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive...

    $718 - $1,985
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  • SR-144528

    Biovision | SR-144528 | B2615

    SR-144528 is a cannabinoid (CB) receptor 2 inverse agonist (Ki values ranging from 0.3 to 5.6 nM). Displays >700-fold selectivity for CB2 over CB1 receptors. Blocks the effects of CP-55,940 on...

    $1,292 - $4,277
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  • MRTX-1257

    Biovision | MRTX-1257 | B2614

    MRTX-1257 is a potent, selective, and irreversible covalent inhibitor of KRAS G12C. MRTX-1257 inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC₅₀ of 0.9 nM. Displays high...

    $777 - $1,985
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  • URB597

    Biovision | URB597 | B2613

    URB597 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH). FAAH is the enzyme that hydrolyzes anandamide (AEA) and other simple esters and amides with long unsaturated acyl...

    $777 - $2,209
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  • AEM1

    Biovision | AEM1 | B2611

    AEM1 is an inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 µM. It sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the...

    $718 - $1,866
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  • Chrysin

    Biovision | Chrysin | B2608

    Chrysin is a natural flavonoid that displays antioxidant, anti-inflammatory, and anticancer properties. It inhibits aromatase and also suppresses human immunodeficiency virus (HIV) activation in...

    $665 - $837
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  • Brusatol

    Biovision | Brusatol | B2607

    Brusatol is a quassinoid isolated from the Brucea javanica plant that has recently been shown to inhibit Nrf2 signaling, reduce tumor burden, and ameliorate chemoresistance in both in vitro and in...

    $837 - $2,440
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  • ML-385

    Biovision | ML-385 | B2605

    ML-385 is a potent and selective Nrf2 inhibitor (Nrf2; IC₅₀ = 1.9 µM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1...

    $949 - $2,898
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  • Cilofexor

    Biovision | Cilofexor | B2604

    Cilofexor (GS-9674), is a nonsteroidal bile acid farnesoid X receptor (FXR) agonist. It improves markers of cholestasis and liver injury in patients with PSC. PSC is an incurable rare chronic liver...

    $718 - $1,866
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  • Tropifexor

    Biovision | Tropifexor | B2603

    Tropifexor (LJN452) is a highly potent, non-bile acid FXR (farnesoid X receptor) agonist with an EC₅₀ of 0.2 nM. Potentially useful for the treatment of Cholestatic Liver Diseases and Nonalcoholic...

    $718 - $1,866
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  • BMS-779788

    Biovision | BMS-779788 | B2602

    BMS-779788 is a LXR partial agonist with IC₅₀ values of 68 nM for LXRα and 14 nM for LXRβ. BMS-779788 induces LXR target genes in blood in vivo with an EC₅₀ = 610 nM, a value similar to its in vitro...

    $1,120 - $3,584
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  • A-485

    Biovision | A-485 | B2601

    A-485 is a potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC₅₀ values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). A-485...

    $718 - $1,866
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  • E7820

    Biovision | E7820 | B2600

    E7820 is a small molecule sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule...

    $718 - $1,866
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  • TCE35031

    Biovision | TCE35031 | B2599

    TCE35031 is an analog of Thalidomide (Cat. No. 2020) commonly used as a precursor to PROTACs (proteolysis-targeting chimera technologies) that hijack cereblon as the E3 ubiquitin ligase component...

    $718 - $1,985
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  • AZD-5904

    Biovision | AZD-5904 | B2598

    AZD-5904 is a potent and irreversible inhibitor of human myeloperoxidase (MPO) (IC₅₀ = 140 nM). Displays similar potency in mouse and rat enzymes.AZD-5904 is a potent and irreversible inhibitor of...

    $1,292 - $4,277
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  • Succinobucol

    Biovision | Succinobucol | B2597

    Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects. It displays anti-platelet activity in rabbit and rat blood and reverses the increase in platelet aggregation in...

    $1,180 - $3,703
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  • Emricasan

    Biovision | Emricasan | B2596

    Emricasan (PF-03491390) is an irreversible pan-caspase inhibitor. In a mouse model of α-Fas-induced acute liver injury, the orally-administered caspase inhibitor Emricasan was retained in the liver...

    $837 - $2,440
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  • NS-11021

    Biovision | NS-11021 | B2595

    NS-11021 is a novel KCa1.1 channel activator. At concentrations above 0.3 μM, activates KCa1.1 in a concentration-dependent manner by parallel-shifting the channel activation curves to more negative...

    $1,180 - $3,703
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  • KIRA6

    Biovision | KIRA6 | B2594

    KIRA-6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC₅₀ = 0.6 µM) and blocks oligomerization. It has been shown to...

    $1,120 - $3,584
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  • PKM2 Inhibitor

    Biovision | PKM2 Inhibitor | B2593

    PKM2 inhibitor is a potent pyruvate kinase M2 (PKM2) inhibitor (IC₅₀ = 2.95 μM).PKM2 inhibitor is a potent pyruvate kinase M2 (PKM2) inhibitor (IC₅₀ = 2.95 μM).Biovision | B2593 | PKM2 Inhibitor...

    $1,061 - $3,357
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  • SAR-131675

    Biovision | SAR-131675 | B2592

    SAR-131675 is a potent and specific VEGFR-3 inhibitor. It inhibits VEGFR-3 tyrosine kinase activity (IC₅₀ = 20 nmol/L) and VEGFR-3 autophosphorylation (IC₅₀ = 5 nmol/L) in HEK cells, respectively...

    $949 - $2,727
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  • SB-297006

    Biovision | SB-297006 | B2589

    SB-297006 is a C-C chemokine receptor-3 antagonist (CCR3; IC₅₀ = 39 nM).SB-297006 is a C-C chemokine receptor-3 antagonist (CCR3; IC₅₀ = 39 nM).Biovision | B2589 | SB-297006 DataSheetAlternate...

    $837 - $2,440
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  • MX1013

    Biovision | MX1013 | B2588

    MX-1013, as a potent, irreversible dipeptide caspase inhibitor. It inhibits caspases 1, 3, 6, 7, 8, and 9, with IC₅₀ values ranging from 5 to 20 nm. MX1013 is selective for caspases, and is a poor...

    $1,008 - $3,129
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  • UNBS-5162

    Biovision | UNBS-5162 | B2587

    UNBS5162 is a novel naphthalimide that suppresses the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days is shown to decrease the...

    $837 - $2,440
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  • SKQ1 Bromide

    Biovision | SKQ1 Bromide | B2584

    SKQ1 bromide is a cell-permeable mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS). SKQ1 prevents neuronal loss and synaptic...

    $837 - $2,440
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  • Tolvaptan

    Biovision | Tolvaptan | B2583

    Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist (IC₅₀ = 3 nM for rat receptor) and a diuretic agent. It is selective for V2 over V1 receptors (IC₅₀ = 0.58 μM). Used...

    $1,061 - $3,357
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