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Biovision

  • SGC707

    Biovision | SGC707 | B2846

    SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM and KD of 53 nM. It inhibits the methylation of histones in cells at a...

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  • AGK7

    Biovision | AGK7 | B2843

    AGK7 is an inactive control and an isomer of AGK2. AGK2 is a cell-permeable, selective inhibitor of SIRT2 which is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase (IC₅₀ = 3.5 µM)...

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  • CAY10685

    Biovision | CAY10685 | B2842

    CAY10685 is an active clickable analog of the lysine acetyltransferase inhibitor 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole (CPTH2 hydrochloride). The alkyne moiety reacts with an...

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  • SAHA-Bpyne

    Biovision | SAHA-Bpyne | B2840

    SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag. It is a photoreactive “clickable“ probe. It is used to profile histone deacetylase (HDAC) activities in native...

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  • TZ9

    Biovision | TZ9 | B2835

    TZ9 is a triazine analogue inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B/HHR6B. It docks to the Rad6B catalytic site. It inhibits Rad6B-induced histone H2A ubiquitination, downregulates...

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  • MPI-5a

    Biovision | MPI-5a | B2833

    MPI-5a is a potent and selective inhibitor of Histone Deacetylase 6 (HDAC6) with an IC₅₀ of 36 nM. It inhibits the acetylation of tubulin in cells with an IC₅₀ value of 210 nM.MPI-5a is a potent and...

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  • HPOB

    Biovision | HPOB | B2832

    HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human...

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  • TCS HDAC6 20b

    Biovision | TCS HDAC6 20b | B2831

    TCS HDAC6 20b is an inhibitor of histone deacetylase 6 (HDAC6). It synergistically inhibits the growth of HCT116 cells at a concentration of 5 µM in combination with paclitaxel. It blocks the growth...

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  • JFD00244

    Biovision | JFD00244 | B2830

    JFD00244 is an inhibitor of SIRT2. SIRT2 is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. A major substrate of SIRT2 is α-tubulin. JFD00244 inhibits SIRT2 with an IC₅₀ of 56.7 µM...

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  • OAC3

    Biovision | OAC3 | B2828

    OAC3 (Oct4-activating compound3) is an activator of octamer-binding transcription factor 4 (Oct4). Oct4 is an important regulator of embryonic stem cells pluripotency. It is used to generate induced...

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  • Iberin

    Biovision | Iberin | B2827

    Iberin is a natural isothiocyanate from cruciferous plants. It is a hydrolysis product of glucosinolate. It induces the expression of phase II detoxification enzymes, quinone reductase (QR) and...

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  • Sinefungin

    Biovision | Sinefungin | B2824

    Sinefungin is a natural nucleoside and a structural analog of S-adenosylmethionine (SAM). It inhibits SAM-dependent nucleic acid methyltransferases and exhibits antifungal, antiviral, and...

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  • UNC0224

    Biovision | UNC0224 | B2823

    UNC0224 is a selective G9a Histone Methyltransferase inhibitor. G9a methylates Histone H3 lysine 9, which is required for early embryogenesis. UNC0224 inhibits G9a with an IC₅₀ of 15 nM. It also...

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  • HNHA

    Biovision | HNHA | B2821

    HNHA is an inhibitor of Histone deacetylase (HDAC). It inhibited proliferation of HT1080 human fibrosarcoma cells with an IC₅₀ of 7.5 μM. It induced hyperacetylation, upregulation of p21...

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  • KD 5170

    Biovision | KD 5170 | B2820

    KD 5170 is a broad spectrum, classes I and II HDAC (histone deacetylase) inhibitor. The IC₅₀ for inhibition of HDAC1, HDAC2, HDAC3, HDAC4 is 0.02 μM, 2 μM, 0.075 μM, 0.026 μM respectively, in vitro...

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  • CAY10603

    Biovision | CAY10603 | B2819

    CAY10603 is a selective inhibitor of Histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of HDAC6 is 2 pM, in vitro. CAY10603 inhibited growth of various pancreatic cell lines with IC₅₀ values...

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  • Tenovin-6

    Biovision | Tenovin-6 | B2818

    Tenovin-6 is a SirT2 inhibitor and a p53 activator. It is a water-soluble analog of Tenovin-1. Tenovins inhibit the protein-deacetylase activities of SirT1 and SirT2. The IC₅₀ for inhibiting human...

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  • Butyrolactone 3

    Biovision | Butyrolactone 3 | B2817

    Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the...

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  • Wedelolactone

    Biovision | Wedelolactone | B2811

    Wedelolactone is a natural coumestan that irreversibly inhibits IKK in NF-κB signaling pathway. IKK phosphorylates the IκBα protein, which results in the degradation and dissociation of IκBα from...

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  • BRD9539

    Biovision | BRD9539 | B2810

    BRD9539 is a specific inhibitor of euchromatin histone methyltransferase G9a (EHMT2). EHMT2 catalyzes the methylation of lysine 9 on histone H3. BRD9539 inhibits EHMT2 with an IC₅₀ of 6.3 μM. It also...

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  • CAY10669

    Biovision | CAY10669 | B2806

    CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor). The IC₅₀ for inhibition of PCAF is 662 μM. CAY10669 at 30-60 μM concentration...

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  • Coumarin-SAHA

    Biovision | Coumarin-SAHA | B2805

    Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the...

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  • JGB1741

    Biovision | JGB1741 | B2804

    JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC₅₀ value of JGB1741 in a cell-free assay is 15 μM. The IC₅₀ for cell proliferation...

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  • Sulforaphane

    Biovision | Sulforaphane | B2801

    Sulforaphane is an isothiocyanate found in cruciferous vegetables such as broccoli. It has anti-cancer activity and targets multiple pathways in cancer development. It induces chemopreventative...

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  • 4-Iodo-SAHA

    Biovision | 4-Iodo-SAHA | B2800

    4-iodo-SAHA is a hydrophobic derivative of the class I and class II HDAC (histone deacetylase) inhibitor SAHA. At 1 μM it demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase...

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  • DFHBI-1T

    Biovision | DFHBI-1T | B2799

    DFHBI-1T is a mimic of green fluorescent protein (GFP) fluorophore for imaging RNA in living cells. Fluorescence is activated by binding to Spinach2 or Broccoli aptamers. Displays peak excitation...

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  • BI

    Biovision | BI | B2798

    BI is a derivative of DFHBI (Cat. No. B2797) that binds Broccoli™ with higher affinity and deliver improved cellular fluorescence. In cells, BI has been found to stabilize the Broccoli™ structure and...

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  • DFHBI

    Biovision | DFHBI | B2797

    DFHBI is a cell-permeable non-fluorescent small molecule derived from the GFP chromophore. Upon binding to the “Spinach™” aptamer, DFHBI is converted to a highly fluorescent state that can be...

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  • Zalcitabine

    Biovision | Zalcitabine | B2796

    Zalcitabine is an antiviral pyrimidine nucleoside analog effective against HIV replication. In cells, it is phosphorylated to the active triphosphate form, ddCTP, which acts as a substrate for HIV...

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  • Sotrastaurin

    Biovision | Sotrastaurin | B2795

    Sotrastaurin (AEB071) is a potent pan-PKC (Protein Kinase C) inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively...

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