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Biovision

  • ICR-1 AM

    Biovision | ICR-1 AM | B3147

    ICR-1 is a red fluorescent calcium (Ca2+) indicator for intracellular Ca2+ measurements. It provides deeper tissue penetration and dramatic background reduction in tissues that have high...

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  • Fluo-4 AM

    Biovision | Fluo-4 AM | B3146

    Fluo-4 is a widely used green fluorescent, intracellular calcium (Ca²⁺) indicator. Fluo-4 AM is the membrane permeable form of the calcium indicator. Masking the negative charge using non-polar,...

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  • IPG-4 TMA⁺ Salt

    Biovision | IPG-4 TMA⁺ Salt | B3145

    IPG-4 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-sensitivity to detect small changes in K⁺ concentration. It is a small, synthetic...

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  • IPG-4 AM

    Biovision | IPG-4 AM | B3144

    IPG-4 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-sensitivity to detect small changes in K⁺ concentration. It is a small, synthetic...

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  • IPG-2 TMA⁺ Salt

    Biovision | IPG-2 TMA⁺ Salt | B3143

    IPG-2 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-sensitivity to detect small changes in K⁺ concentration. It is a small, synthetic...

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  • IPG-2 AM

    Biovision | IPG-2 AM | B3142

    IPG-2 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator with Ex/Em: 525 nm/545 nm and a high-sensitivity to detect small changes in K⁺ concentration. It is a small, synthetic...

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  • IPG-1 TMA+ Salt

    Biovision | IPG-1 TMA+ Salt | B3141

    IPG-1 is a small, synthetic fluorochrome which incorporates a K⁺-binding moiety. When K⁺ binds, the quenching is relieved and the fluorescence dramatically increases. IPG-1 has Ex/Em: 525 nm/545 nm...

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  • IPG-1 AM

    Biovision | IPG-1 AM | B3140

    IPG-1 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator for measuring changes at most intracellular K⁺ concentrations. It is a small, synthetic fluorochrome which incorporates a...

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  • NCC007

    Biovision | NCC007 | B3139

    NCC007 is an inhibitor of casein kinase I (CKI) and a modulator of circadian rhythm. It inhibits CKIα and CKIδ with an IC₅₀ of 1.8 and 3.6 μM. It shows stronger period effects (0.32 μM for 5 h period...

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  • ING-2 TMA+ Salt

    Biovision | ING-2 TMA+ Salt | B3138

    ING-2 is a yellow-green fluorescent intracellular sodium Na⁺ indicator. It is a small, synthetic fluorochrome fused with a Na⁺-binding moiety. When Na⁺ binds to ING-2, the quenching is relieved, and...

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  • ING-2 AM

    Biovision | ING-2 AM | B3137

    ING-2 AM is the membrane permeable form of the sodium indicator ING-2 (Cat. No. B3138). Masking the negative charge using non-polar, ester-linked moieties (AM ester) allows the molecule to enter...

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  • Longdaysin

    Biovision | Longdaysin | B3136

    Longdaysin is a potent modulator of circadian rhythm. It slows the circadian clock both in cultured mammalian cells and zebrafish. It inhibits the protein kinases CKIδ, CKIα, ERK2, and CDK7...

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  • BMS-P5

    Biovision | BMS-P5 | B3135

    BMS-P5 is a potent and selective inhibitor of peptidylarginine deiminase 4 (PAD4). It significantly reduces Multiple myeloma-cells induced citrullination of histone H3 and formation of neutrophil...

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  • 2-Chloroadenosine

    Biovision | 2-Chloroadenosine | B3129

    2-Chloroadenosine is an adenosine receptor agonist. It binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1900 nM, respectively. It significantly decreases seizures in a rat...

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  • 1-EBIO

    Biovision | 1-EBIO | B3127

    1-EBIO is an activator of Ca2+- and cAMP-sensitive K+ channels. It stimulates a sustained Cl- secretory response with an EC₅₀ of 490 μM. It induces cardiogenesis of pluripotent stem cells.1-EBIO is...

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  • IM156

    Biovision | IM156 | B3126

    IM156 is a bioenergetic biguanide derivative which blocks mitochondrial complex I and an activator of AMP-activated protein kinase (AMPK). It is a derivative of metformin. IM156 causes energy...

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  • TVB-2640

    Biovision | TVB-2640 | B3125

    TVB-2640 is an oral, selective fatty acid synthase (FASN) inhibitor. It reduces hepatic de novo lipogenesis in males with metabolic abnormalities. It is being evaluated in phase 2 clinical trials to...

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  • AZD-4205

    Biovision | AZD-4205 | B3124

    AZD-4205 is a highly selective Janus Kinase 1 (JAK1) inhibitor with an IC₅₀ of 0.07 μM. It shows antitumor activity in combination with the EGFR inhibitor, osimertinib, in a preclinical...

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  • 1,4-DPCA

    Biovision | 1,4-DPCA | B3123

    1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase. It inhibits isolated chick prolyl 4-hydroxylase and procollagen synthesis in human foreskin fibroblasts with an IC₅₀ value of 3.6 and 2.4...

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  • Ponesimod

    Biovision | Ponesimod | B3121

    Ponesimod is a potent agonist of sphingosine-1-phosphate receptor 1 (S1P1) receptor. It reduces the circulating lymphocytes at a dose of 3-100 mg/kg in a rat model. It selectively activates S1P1 in a...

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  • Acefylline

    Biovision | Acefylline | B3119

    Acefylline is a xanthine derivative which acts as potential Peptidylarginine deiminase (PAD) activator. It increases the in vitro deimination of filaggrin by PAD1 and PAD3 at a concentration of 200...

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  • Sarcosine

    Biovision | Sarcosine | B3116

    Sarcosine is an intermediate in the metabolism of glycine. Sarcosine is an antagonist of glycine transporter-1 (GlyT1) with an IC₅₀ value of 91 μM. It has beneficial effects in schizophrenia...

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  • Perphenazine

    Biovision | Perphenazine | B3115

    Perphenazine is a dopamine receptor antagonist. It binds to Dopamine receptors D₂, D₃ and D₄ with Ki values of 0.56 nM, 0.43 nM and 28.5 nM respectively. It also binds to serotonin receptors 5-HT1A,...

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  • UNC2250

    Biovision | UNC2250 | B3111

    UNC2250 is an inhibitor of Mer receptor tyrosine kinase. It inhibits steady-state phosphorylation of endogenous Mer with an IC₅₀ of 9.8 nM. It blocks ligand-stimulated activation of a chimeric...

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  • FPH1

    Biovision | FPH1 | B3109

    FPH1 also known as Functional Proliferation Hit 1 induces functional proliferation of hepatocytes in vitro. It promotes the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps)...

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  • Osilodrostat

    Biovision | Osilodrostat | B3108

    Osilodrostat is a potent inhibitor of the enzymes 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), which catalyze the final steps of cortisol and aldosterone biosynthesis, respectively,...

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  • Opicapone

    Biovision | Opicapone | B3107

    Opicapone is a potent inhibitor of catechol-O-methyltransferase (COMT). It inhibits rat peripheral COMT with ED₅₀ values below 1.4 mg/kg up to 6 h post-administration. It is approved for use as...

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  • Ripretinib

    Biovision | Ripretinib | B3106

    Ripretinib is an inhibitor of receptor tyrosine kinase (KIT) and platelet derived growth factor receptor A (PDGFRA). In vitro kinase inhibition studies show that ripretinib inhibits wild-type KIT and...

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  • DMSO (Anhydrous)

    Biovision | DMSO (Anhydrous) | B3105

    DMSO is a highly polar aprotic organic solvent. It is widely used to dissolve both polar and nonpolar compound. It penetrates biological membranes and is used as a vehicle for topical application of...

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  • GSK-923295

    Biovision | GSK-923295 | B3104

    GSK923295 is an allosteric inhibitor of CENP-E kinesin motor ATPase activity. It inhibits CENP-E microtubule-stimulated ATPase activity with a Ki of 3.2 ± 0.2 nM. It inhibits the growth of tumor cell...

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  • AZD-2461

    Biovision | AZD-2461 | B3103

    AZD-2461 is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP1 and PARP2 with IC₅₀ values of 5 nM and 2 nM. It has lower affinity for P-glycoprotein and suppresses the development...

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  • Xylitol

    Biovision | Xylitol | B3101

    Xylitol is a sugar alcohol derived from xylose by reduction of the carbonyl group. It is used as a food additive and sugar substitute. It is found in many fruits and vegetables. It is added to some...

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  • TEMPOL

    Biovision | TEMPOL | B3100

    TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It is a membrane permeable, free radical scavenger. It inhibits lipid peroxidation induced by iron...

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  • Digoxigenin

    Biovision | Digoxigenin | B3099

    Digoxigenin is the aglycone of digoxin. It is commonly used as a non-radioactive labeling reagent for the detection of RNA, DNA and proteins. Digoxigenin-labeled probes are used in situ hybridization...

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  • ML133 Hydrochloride

    Biovision | ML133 Hydrochloride | B3097

    ML133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor. It inhibits Kir2.1 with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. It is selective for Kir2 channels over Kir1.1 and Kir4.1...

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  • Lexibulin

    Biovision | Lexibulin | B3096

    Lexibulin is an orally available inhibitor of microtubule polymerization with an IC₅₀ of 3 µM. It blocks cell cycle at the G2-M phase, which leads to cell death. It is cytotoxic to various cell lines...

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