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Biovision

  • (−)-Huperzine A

    Biovision | (−)-Huperzine A | B3095

    (−)-Huperzine A is a potent and reversible inhibitor of acetylcholinesterase. It shows an IC₅₀ value of 82 nM against acetylcholinesterase in the rat cortex in vitro. It also acts as an antagonist of...

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  • Pentylenetetrazole

    Biovision | Pentylenetetrazole | B3090

    Pentylenetetrazole is a circulatory and respiratory stimulant. It is a central nervous system modulator used to experimentally induce seizures in animals. It acts as an antagonist of GABAa receptors...

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  • Metergoline

    Biovision | Metergoline | B3088

    Metergoline is a serotonin (5-HT) receptor antagonist. It is active at 5-HT1 (pKi=7.8 for 5-HT1B), 5-HT2 (pKi=8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C respectively) and 5-HT7 (pKi=16 nM)...

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  • Elbasvir

    Biovision | Elbasvir | B3087

    Elbasvir is a potent inhibitor of Hepatitis C virus (HCV), non-structural protein 5A (NS5A). It is active against many HCV genotypes with EC₅₀ values in the picomolar range (0.0003 nM-3.4 nM). It is...

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  • Darunavir

    Biovision | Darunavir | B3086

    Darunavir is an HIV-1 protease inhibitor with an IC₅₀ of 3 nM and cytoxicity of 74.4 μM. It is also also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in...

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  • Trabectedin

    Biovision | Trabectedin | B3084

    Trabectedin is a natural product originally isolated from the sea squirt, Ecteinascidia turbinata and is currently prepared synthetically. It interferes with transcription factors, DNA‐binding...

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  • Dexmedetomidine

    Biovision | Dexmedetomidine | B3083

    Dexmedetomidine is an imidazole derivate and an active d-isomer of medetomidine. Medetomidine is a racemate of the stereoisomers levomedetomidine and dexmedetomidine. Dexmedetomidine is a potent...

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  • BIBR-1532

    Biovision | BIBR-1532 | B3082

    BIBR-1532 is a highly potent mixed-type non-competitive inhibitor of telomerase. It inhibits telomerase in a dose-dependent manner, with an IC₅₀ of 93 nM. It specifically targets the telomerase...

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  • (-)-Equol

    Biovision | (-)-Equol | B3081

    S-equol is a metabolite of soy isoflavonoid phytoestrogen daidzein, produced by human intestinal bacteria. S-equol has a high affinity for estrogen receptor beta (ERβ) than estrogen receptor (ERα)...

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  • GRL-0617

    Biovision | GRL-0617 | B3079

    GRL-0617 is a potent inhibitor of the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro cleaves the viral polyproteins. GRL-0617...

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  • Mapracorat

    Biovision | Mapracorat | B3078

    Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis...

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  • Sarecycline

    Biovision | Sarecycline | B3077

    Sarecycline is a semi-synthetic tetracycline, narrow-spectrum antibiotic, being developed to treat patients suffering from moderate to severe acne vulgaris. Sarecycline is more active than...

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  • GS-441524

    Biovision | GS-441524 | B3076

    GS-441524 is the predominant metabolite of remdesivir in blood and is the nucleoside of the prodrug remdesivir. It is phosphorylated to the active triphosphate metabolite which incorporates into RNA...

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  • ONC-201

    Biovision | ONC-201 | B3075

    ONC-201 is an orally active transcriptional inducer of Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). It induces TRAIL in a p53-independent manner at concentrations of 1.25 μM-5 μM...

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  • Afatinib dimaleate

    Biovision | Afatinib dimaleate | B3072

    Afatinib is an irreversible dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinase. It shows IC₅₀ values of 0.5 nM and 14 nM for...

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  • (S)-Crizotinib

    Biovision | (S)-Crizotinib | B3071

    (S)-crizotinib is a low nanomolar inhibitor of 7,8-dihydro-8-oxoguanine triphosphatase (MTH1 or NUDT1) whereas the (R)-enantiomer shows IC₅₀ values in the micromolar range. MTH1 aids in...

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  • Golgicide A

    Biovision | Golgicide A | B3070

    ADP-ribosylation factor 1 (Arf1) plays an important role in regulating secretory traffic and membrane transport within the Golgi. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs)...

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  • CHIR-124

    Biovision | CHIR-124 | B3069

    CHIR-124 is a quinolone-based inhibitor of Checkpoint kinase-1 (Chk1). It potently and selectively inhibits Chk1 in vitro with an IC₅₀ of 0.3 nM. It interacts synergistically with topoisomerase...

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  • Riluzole

    Biovision | Riluzole | B3068

    Riluzole is a benzothiazole derivative which inhibits glutamatergic neurotransmission and blocks voltage-dependent sodium channels (ED₅₀ = 2.3 μM). It reduces the uptake of GABA from neuronal synapse...

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  • LDN-193189

    Biovision | LDN-193189 | B3067

    LDN-193189 inhibits the activity of the Bone Morphogenetic Protein (BMP) type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the...

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  • GSA 10

    Biovision | GSA 10 | B3065

    GSA 10 is a novel, potent activator of the smoothened receptor (Smo). GSA 10 acts at Smo and promotes the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 µM)...

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  • JTE-607

    Biovision | JTE-607 | B3064

    JTE-607 is a multiple cytokine inhibitor. It inhibits cytokine production specifically in human peripheral blood mononuclear cells without causing immunosuppression. It inhibits tumor necrosis...

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  • R-7050

    Biovision | R-7050 | B3063

    R-7050 is a cell-permeable inhibitor of signaling through the TNFα receptor (TNFαR) complex. It blocks the formation of signal-initiating complexes that consist of TNFα receptor (TNFαR) I, TNFαR...

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  • C87

    Biovision | C87 | B3062

    C87 is an inhibitor of Tumor Necrosis Factor α (TNFα). It binds to human TNFα with a KD of 110 nM and potently inhibits TNFα-induced cytotoxicity in L929 cells with an IC₅₀ of 8.73 μM. It effectively...

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  • BAY-678

    Biovision | BAY-678 | B3061

    BAY-678 is a potent, selective, cell-permeable inhibitor of human neutrophil elastase (HNE).The activity of HNE is increased in inflammatory diseases. BAY-678 shows Ki values of 15 nM and 600 nM for...

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  • BAY-677

    Biovision | BAY-677 | B3060

    BAY-677 is a negative control for BAY-678. BAY-678 is a potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 20 nM. The S-enantiomer BAY-677 inhibits HNE...

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  • Tucidinostat

    Biovision | Tucidinostat | B3059

    Tucidinostat is an inhibitor of histone deacetylases (HDACs) with IC₅₀ values of 95 nM, 160 nM, 67 nM and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10 respectively. It shows potent antitumor activity. It...

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  • Gabexate mesylate

    Biovision | Gabexate mesylate | B3058

    Gabexate is an inhibitor of serine proteases. It inhibits plasma kallikrein, thrombin, plasmin, factor Xa with Ki values of 0.2 μM, 0.97 μM, 1.6 μM and 8.5 μM. It exerts an anticoagulant effect on...

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  • E-64d

    Biovision | E-64d | B3057

    E-64d is a synthetic analog of E-64 which is a membrane permeable inhibitor of lysosomal and cytosolic cysteine proteases. It inhibits cathepsins B and L in intact lysosomes and cells. It (20-200...

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  • Prazosin

    Biovision | Prazosin | B3055

    Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs). The affinity estimates (pKi) for inhibition of [3H]-prazosin binding to CHO-K1 cells expressing cloned human α1A, α1B and α1D...

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  • FITC-Tyramide

    Biovision | FITC-Tyramide | B3054

    Tyramide signal amplification is an enzyme-catalyzed deposition of tyramide on or near a protein or nucleic acid in situ. The enzyme horseradish peroxidase (HRP) converts the labelled tyramide...

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  • Siramesine

    Biovision | Siramesine | B3053

    Siramesine is an agonist for sigma-2 (σ2) receptor. It is selective for σ2 over σ1 with IC₅₀ values of 0.12 nM and 17 nM respectively. It shows potent anxiolytic-like effects in rodents. The minimal...

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  • Omeprazole

    Biovision | Omeprazole | B3052

    Omeprazole is a proton pump inhibitor (PPI). It inhibits gastric H+/K+ ATPase with an IC₅₀ of 1.1 μM. It shows competitive inhibition of cytochrome P450 enzyme CYP2C19 activity with a Ki of 2-6 μM...

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  • RIPA-56

    Biovision | RIPA-56 | B3051

    RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced...

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  • Astemizole

    Biovision | Astemizole | B3050

    Astemizole is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG potassium channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole shows synergistic...

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  • S1RA (E-52862)

    Biovision | S1RA (E-52862) | B3048

    S1RA is a highly selective sigma-1 (σ1) receptor antagonist. It shows high affinity for σ1 receptors with Ki values of 17 nM and 23.5 nM for human and guinea pig σ1 receptors respectively but no...

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  • Pridopidine

    Biovision | Pridopidine | B3045

    Pridopidine is a phenylpiperidine dopaminergic stabilizer. It is a low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist. The affinity of pridopidine for S1R is...

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