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Biovision | GBR-12909 | B3043

GBR-12909 is a potent and selective inhibitor of dopamine uptake (Ki = 1 nM). It inhibits dopamine uptake in tissue slices obtained from rat neostriatum at nanomolar concentrations. GBR-12909 (10...

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Biovision | Cepharanthine | B3042

Cepharanthine is an alkaloid extracted from the plant Stephania cepharantha Hayata. It shows antimalarial, antiviral, anti-inflammatory, and antitumor activities. The IC₅₀ values against different...

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Biovision | Nitazoxanide | B3041

Nitazoxanide is a nitrothiazole benzamide with anti-parasitic and anti-viral activity. It inhibits pyruvate-ferredoxin oxidoreductase in protozoa and anaerobic bacteria. It inhibits many anerobes in...

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Biovision | Umifenovir | B3040

Umifenovir is an indole derivative with broad-spectrum antiviral activity. It inhibits virus-mediated fusion with target membrane and blocks virus entry into target cells. It shows antiviral activity...

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Biovision | N4-Hydroxycytidine | B3039

N4-Hydroxycytidine is a ribonucleoside analog with broad-spectrum antiviral activity. The prodrug of N4-hydroxycytidine is EIDD-2801. N4-Hydroxycytidine is active against influenza, Ebola, Severe...

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Biovision | Triclabendazole | B3038

Triclabendazole is a benzimidazole anthelminthic drug that binds to tubulin. TCBZ is used to treat liver fluke (Fasciola hepatica) infections in cattle and humans. It is effective against...

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Biovision | Siponimod (BAF-312) | B3037

Siponimod is an orally bioavailable agonist of the sphingosine-1-phosphate (S1P) receptor that is selective for S1P1 and S1P5 with EC₅₀ values of 0.39 and 0.98 nM respectively, in a GTPγS-binding...

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Biovision | Meglumine | B3036

Meglumine is a derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. It is used as an excipient for drug formulations and for preparing salts. The...

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Biovision | Tafamidis | B3035

Tafamidis is a potent kinetic stabilizer of transthyretin (TTR). Tafamidis binds selectively and with negative cooperativity (Kd values ∼2 nM and ∼200 nM) to the two normally unoccupied...

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Biovision | Pretomanid (PA-824) | B3033

Pretomanid is a nitroimidazopyran active againt Mycobacterium tuberculosis. It is active against multidrug-resistant M. tuberculosis clinical isolates with MIC

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Biovision | Lasmiditan hemisuccinate | B3032

Lasmiditan hemisuccinate is a highly selective serotonin 5-HT(1F) receptor agonist. It shows high-affinity for 5-HT(1F) receptor with a Ki value of 2.21 nM in vitro. Oral administration of lasmiditan...

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Biovision | GBT-440 | B3031

GTB-440 is a modulator of sickle hemoglobin S (HbS). It binds to the N‐terminal valine of one of the haemoglobin α chains and increases HbS affinity for oxygen. GBT440 dose‐dependently increases HbS...

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Biovision | Semaglutide acetate | B3030

Semaglutide is an agonist of glucagon-like peptide 1 receptor (GLP-1R). It is a glucagon-like peptide-1 (GLP-1) analogue approved for the treatment of type 2 diabetes mellitus. It has two amino acid...

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Biovision | Nidufexor | B3029

Nidufexor is an agonist of Farnesoid X receptor (FXR). Administration of Nidufexor (10 and 30 mg/kg for 3 weeks) modulates FXR-dependent genes in vivo leading to the reduction of steatosis,...

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Biovision | Licogliflozin | B3028

Licogliflozin is a dual inhibitor of Sodium/glucose cotransporters SGLT1 and SGLT2 with a higher selectivity for SGLT2 (in vitro IC₅₀ values of 20.6 and 0.58 nM, respectively). It causes a reduction...

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Biovision | Aramchol | B3027

Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It...

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Biovision | Cenicriviroc | B3026

Cenicriviroc is a potent inhibitor of C-C chemokine receptors CCR5 and CCR2. It is an orally bioavailable derivative of TAK-779 with potent anti-HIV-1 activity. It blocks the binding of MIP-1α and...

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Biovision | Tucatinib | B3025

Tucatinib is an oral, potent, selective and ATP-competitive small-molecule inhibitor of Receptor tyrosine-protein kinase ErbB2 (also called HER2 or human epidermal growth factor receptor 2) with an...

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Biovision | Ertapenem sodium | B3024

Ertapenem is a carbapenem broad spectrum antibiotic effective against Gram-positive and Gram-negative bacteria. It binds to the penicillin binding proteins (PBPs) and has high affinity for PBPs 2 and...

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Biovision | Netilmicin Sulfate | B3023

Netilimicin is an aminoglycoside antibiotic. It is active against S. aureus, N. gonorrhoeae, E. coli, P. mirabilis, and P. aeruginosa (MIC values = 0.4, 3.1, 0.8, 1.6, and 0.4 µg/ml, respectively) as...

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Biovision | Maduramicin Ammonium | B3022

Maduramicin is a natural polyether ionophore antibiotic first isolated from the actinomycete Actinomadura rubra. It is commonly used in veterinary medicine as an anti-coccidial agent. It is cytotoxic...

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Biovision | Famotidine | B3021

Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine...

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Biovision | Narasin | B3020

Narasin is an ionophore antibiotic which is a derivative of salinomycin. It modifies the permeability of cellular membranes to cationic metal species. It inhibits NF-κB signaling via inhibition of...

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Biovision | AMG-517 | B3019

AMG-517 is an antagonist of transient receptor potential vanilloid 1 (TRPV1) with an IC₅₀ of 0.9 nM. It inhibits post-burn mechanical and thermal allodynia in a rat model of burn injury when...

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Biovision | LM22B-10 | B3018

LM22B-10 is an activator of Tropomyosin-receptor kinase neurotrophin receptors TrkB and TrkC. It binds to TrkB and TrkC in a dose-dependent manner at concentrations of 250 nM-2000 nM. It increases...

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Biovision | Ro 08-2750 | B3017

Ro 08-2750 is an antagonist of nerve growth factor (NGF). It binds to the NGF dimer (Kd ~ 1 μM) and probably induces a change in its conformation such that NGF cannot bind to neurotrophin receptor...

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Biovision | ML-193 | B3016

ML-193 is a selective quinoline aryl sulfonamide antagonist for GPR55, a lysophosphatidylinositol (LPI)-sensitive receptor that is also involved in cannabinoid signaling. It inhibits GPR55 with an...

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Biovision | Arachidonoyl 2'-Chloroethylamide | B3015

Arachidonyl-2-chloroethylamide (ACEA) is a high affinity agonist of cannabinoid receptor CB1. It binds to the CB1 receptor with high affinity (Ki value of 1.4 nM) and to the CB2 receptor with low...

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Biovision | Baloxavir marboxil | B3014

Baloxavir marboxil is a prodrug that is metabolised to the active form baloxavir acid also known as S‐033447. S‐033447 is a small molecule inhibitor of the cap‐dependent endonuclease of influenza A...

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Biovision | Istradefylline | B3013

Istradefylline is an adenosine receptor 2A (A2A) antagonist with a Ki value of 2.2 nM in a radioligand binding assay. Oral administration of Istradefylline reverses motor disability without inducing...

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Biovision | WIN 55,212-2 Mesylate | B3012

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkyl indole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. It shows...

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Biovision | (S)-(-)-Bay K 8644 | B3011

(S)-(-)-Bay K 8644 is a L-type Ca channel agonist while R-(+)-Bay K8644 is an antagonist. (S)-(-)-Bay K 8644 causes a left shift in the Q1 (activation charge) vs. V activation curve at nanomolar...

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Biovision | MGL-3196 | B3010

A selective thyroid hormone receptor β agonist with EC₅₀ values of 0.21 and 3.74 µM for THRβ and THRα, respectively. It significantly lowers non-HDL-C and liver TG in hypercholesterolemic rat and...

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Biovision | Alofanib | B3009

Alofanib is a novel selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase. It inhibits phosphorylation of FGF receptor substrate 2α (FRS2α) with IC₅₀ values of...

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Biovision | Roblitinib | B3008

Roblitinib is a reversible-covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) tyrosine kinase. It shows 1000-fold selectivity for FGFR4 over FGFR1/2/3 and other kinases, with an IC₅₀...

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Biovision | Merestinib | B3007

Merestinib is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM. It shows more anti-proliferative activity in cell lines with MET gene...

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Biovision | Savolitinib | B3006

Savolitinib is an inhibitor of cMET tyrosine kinase or hepatocyte growth factor receptor (HGFR). It potently inhibits the tyrosine kinase activity of recombinant cMET in vitro with an IC₅₀ value of 4...

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Biovision | Capmatinib | B3005

Capmatinib is an ATP competitive inhibitor of c-MET kinase or hepatocyte growth factor receptor (HGFR). Binding of Hepatocyt Growth Factor to c-MET receptor causes activation of multiple downstream...

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Biovision | Theliatinib | B3004

Theliatinib is a potent epidermal growth factor receptor EGFR tyrosine kinase inhibitor with a Ki value of 0.05 nM and IC₅₀ of 3 nM. It exhibits strong antitumor activity in patient-derived estrogen...

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Biovision | Icotinib | B3003

Icotininb is a potent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC₅₀ of 5 nM. It blocks EGFR-mediated intracellular tyrosine phosphorylation IC₅₀ of 45 nM in the...

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Biovision | Allitinib | B3002

Allitinib is a novel anilino-quinazoline compound that inhibits ErbB tyrosine kinases: epidermal growth factor receptor (EGFR) and ErbB2. It inhibits EGFR and ErbB2 with IC₅₀ values of 0.5 nM and 3...

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Biovision | EZSolution™ D-Luciferin, Potassium Salt | B3001

Luciferin is a substrate for luciferase. It is oxidised by luciferase to generate light in the presence of ATP. Luciferase is used as a reporter gene linked to a promoter of interest. Luciferin is...

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Biovision | Brite-Light™ D-Luciferin, Potassium Salt | B3000

Luciferin is a substrate for luciferase. It is oxidised by luciferase to generate light in the presence of ATP. Luciferase is used as a reporter gene linked to a promoter of interest. Luciferin is...

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Biovision | Avapritinib | B2999

Avapritinib is an inhibitor of oncogenic KIT and PDGFRA mutations. The KIT receptor belongs to the class III receptor tyrosine kinase (RTK) family. Avapritinib potently inhibits the activation loop...

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Biovision | Branebrutinib | B2998

Branebrutinib is a potent covalent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor tyrosine kinase. It is a member of the Tec family of kinases and is essential for B...

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Biovision | Remdesivir | B2997

Remdesivir is a nucleoside analogue with antiviral activity. It inhibits Middle East respiratory syndrome coronavirus (MERS-CoV)- or severe acute respiratory syndrome coronavirus (SARS-CoV)-infected...

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Biovision | Selpercatinib | B2996

Selpercatinib is a RET kinase inhibitor with IC₅₀ values ranging from 1 nM to 4 nM for wild type and mutant RET kinase. It has shown promising results in early phase clinical trials for RET-driven...

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Biovision | Avitinib | B2995

Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR) receptor tyrosine kinase. It inhibits EGFR L858R/T790M double mutations with an IC₅₀ value...

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Biovision | (-)-Quinpirole hydrochloride | B2994

Quinpirole is a dopamine D2 receptor agonist with Ki values of 4.8 nM, 24 nM, 30nM and 1900 nM at D2, D3, D4 and D1 receptors respectively. Quinpirole inhibits single pulse dopamine overflow in a...

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Biovision | Cetirizine dihydrochloride | B2993

Cetirizine is a selective histamine H1 receptor antagonist with a Ki of 6 nM. It is a highly efficacious, well-tolerated, treatment for the management of Allergic Rhinitis. Cetirizine exerts...

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Biovision | 2-Arachidonoylglycerol | B2992

2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid G-protein coupled receptors (CB1 and CB2) with Ki values of 472 nM and 1400 nM respectively...

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Biovision | CMPD-1 | B2991

MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a...

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