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Biovision | Biochanin A | B2794

Biochanin A is an isoflavone phytoestrogen found in red clover that acts as a selective agonist at ER-β estrogen receptors, and may have chemopreventive efficacy against breast cancer. Biochanin A is...

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Biovision | CAY-10499 | B2793

CAY-10499 is a potent non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively).CAY-10499 is a potent non-selective lipase inhibitor (IC50s =...

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Biovision | Tectorigenin | B2792

Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants. It has been reported to display a variety of biological activities including antitumor and antibacterial effects, free...

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Biovision | BMS-935177 | B2791

BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor (IC50 = 2.8 nM). It is more potent against BTK than other kinases, including the other Tec family kinases (TEC, BMX, ITK,...

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Biovision | ARQ-531 | B2790

ARQ-531 is a potent, reversible non-covalent Bruton’s Tyrosine Kinase (BTK) inhibitor, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.ARQ-531 is a potent, reversible...

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Biovision | Orelabrutinib (ICP-022) | B2789

Orelabrutinib is a potent and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor...

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Biovision | PCI-29732 | B2788

PCI-29732 is a selective and irreversible BTK (Bruton’s tyrosine kinase) inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. Blocks B cell antigen receptor (BCR)-mediated gene...

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Biovision | Adaphostin | B2787

Adaphostin is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM) that displays anti-proliferative activity in leukemia models, human prostate cancer cell line PC-3 and other cancer cell lines...

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Biovision | (-)-Arctigenin | B2786

Arctigenin is a lignan found in the root of A. lappa. It displays antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt...

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Biovision | MKC-8866 | B2785

MKC-8866 is a potent, and selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. MKC-8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression...

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Biovision | Desmosterol | B2784

Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It may be associated with the pathogenesis of...

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Biovision | 3-Acetyl-11-keto β boswellic acid | B2783

3-Acetyl-11-keto β boswellic acid (AKBA) is a naturally occurring pentacyclic triterpene that acts as an antiangiogenic and neuroprotective agent, reducing the impact of proliferative retinopathies,...

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Biovision | Tetrahydropiperine | B2782

Tetrahydropiperine is a derivative of piperine (Cat. No. B2086) that displays various biological activities. It acts as an agonist of transient receptor potential vanilloid type 1 (TRPV1; EC50 = 6.3...

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Biovision | Tetrahydrocurcumin | B2781

Tetrahydrocurcumin (THC) is a major metabolite of curcumin that displays antioxidant and anti-inflammatory properties. It has been shown to have protective effects against diabetes and vascular...

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Biovision | Sesamolin | B2780

Sesamolin is a furofuran lignan extracted from sesame seeds. It displays beneficial biological properties such as antioxidant, anti-mutagenic, anti-aging and anti-inflammatory activities. Also known...

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Biovision | Montelukast sodium | B2779

Montelukast is a brain-penetrant cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 4.9 nM in HEK293 cell membranes expressing the human receptor). It is selective for CysLT1 over CysLT2...

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Biovision | Psoralen | B2778

Psoralen belongs to the family of furanocoumarins that intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by...

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Biovision | Phyllanthin | B2777

Phyllanthin is a major bioactive lignan found in many Phyllanthus species. It displays various biochemical and pharmacological properties especially on its hepatoprotective effects. It scavenges DPPH...

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Biovision | Lupeol | B2775

Lupeol is a dietary triterpene that displays potent potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell...

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Biovision | Hibifolin | B2774

Hibifolin, a flavonol glycoside derived from herbal plants, displays strong protective activity against cell death induced by aggregated beta-amyloid (A beta). Hibifolin also acts as a potential...

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Biovision | (Z)-Guggulsterone | B2773

(Z)-Guggulsterone is a synthetic form of the guggul tree plant steroid that displays an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X...

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Biovision | Conessine | B2772

Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors. Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors...

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Biovision | Aloe-emodin | B2771

Aloe-emodin is a hydroxyanthraquinone found naturally in aloe plants. It displays antibacterial, antiviral, anti-inflammatory and hepatoprotective effects. Acts as a laxative/cathartic compound;...

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Biovision | Adenosine | B2770

Adenosine is a purine nucleoside that serves as an endogenous ligand of a family of four adenosine receptors, which serve diverse roles related to smooth muscle tone, central nervous system...

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Biovision | 20-Hydroxy ecdysone (Ecdysterone, β) | B2769

20-Hydroxyecdysone (20E) is an important steroid hormone that controls embryonic development, molting, metamorphosis, and reproduction in members of the phylum Arthropoda. It acts through a...

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Biovision | 12-Deoxywithastramonolide | B2768

12-Deoxywithastramonolide is a withanolide found in W. somnifera roots that displays anti-inflammatory activity, reducing TNF-α and increasing IL-10 production in mice 12-Deoxywithastramonolide also...

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Biovision | Filastatin | B2767

Filastatin is a nontoxic inhibitor of adhesion to human cells. Filastatin blocks the ability of Candida albicans, and other Candida sp. to bind to polystyrene, and human A549 cell monolayers...

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Biovision | Etodolac | B2766

Etodolac id a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC50 values are 53 and >100 μM for COX-2 and COX-1 respectively). Displays...

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Biovision | CVT-10216 | B2765

CVT-10216 is a potent, selective, and reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT-10216 has been reported to...

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Biovision | BT2 (BCKDC Kinase Inhibitor) | B2764

BT2 is an inhibitor of the mitochondrial branched-chain a-ketoacid dehydrogenase complex kinase (BCKDC) - IC50 = 3.19 µM. Inhibition of this kinase has been shown to reduce levels of branched-chain...

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Biovision | PF-04929113 | B2763

PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04958473 (SNX-2112). It binds both Hsp90α and Hsp90β with an IC50 value of 30 nM. PF-04929113, is rapidly absorbed and converted into the active...

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Biovision | YK-3-237 | B2762

YK-3-237 is a sirtuin 1(SIRT1) activator. It activates SIRT1 in a concentration-dependent manner and reduces acetylation of wild-type and mutant p53 in a SIRT1-dependent manner YK-3-237 inhibits cell...

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Biovision | OSS-128167 | B2761

OSS-128167 is a potent and selective inhibitor of sirtuin 6 (SIRT6; IC50 = 89 μM). It displays selectivity for SIRT6 over SIRT1 and SIRT2 (IC50s = 1,578 and 751 μM, respectively). OSS-128167...

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Biovision | MDL-800 | B2760

MDL-800 is a potent and selective allosteric activator (EC50 = 10.3 µM) of SIRT6, a member of the SIRT deacetylase family. Does not display any activities toward SIRT1, SIRT3, SIRT4 and HDAC1-11 at...

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Biovision | UBCS-039 | B2759

UBCS-039 is the first synthetic SIRT6 activator (EC50 = 38 μM); induces a time-dependent activation of autophagy in several human tumor cell lines. UBCS-039 induces deacetylation of SIRT6-targeted...

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Biovision | BMS-1001 free base | B2758

BMS-1001 is a potent inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) (IC50 = 2.25 nM). BMS-1001 is capable of alleviating...

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Biovision | PLpro inhibitor | B2757

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) (IC50 = 2.6 µM). PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 µM and an EC50 of 21.0 µM.PLpro inhibitor is a...

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Biovision | Neoseptin-3 | B2756

Neoseptin-3 is a Toll-like receptor 4/myeloid differentiation factor 2 (mTLR4/MD-2) agonist (EC50 of 18.5 μM). Neoseptin-3 stimulates the activity of mouse TLR4 (mTLR4)/myeloid differentiation factor...

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Biovision | JZL-184 | B2755

JZL-184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain...

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Biovision | P1,P5-Di(adenosine-5′)-pentaphosphate ammonium salt | B2754

P1,P5-di(adenosine-5′)-pentaphosphate ammonium salt is a potent inhibitor of heat shock protein 78 in Leishmania donovani (LdHSP78). LdHSP78 is a putative ClpB protease, that is important for...

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Biovision | 6877002 | B2753

6877002 is a CD40-TRAF6 interaction inhibitor compound that specifically targets TNF receptor-associated factor 6 (TRAF6; Kd = 97 µM for TRAF6 C-domain) and disrupts its functional coupling with CD40...

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Biovision | RMC-4550 | B2752

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 (IC50 = 0.583 nM). RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but...

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Biovision | Dihomo-γ-Linolenic Acid | B2751

Dihomo-γ-Linolenic Acid (DGLA, 20:3), an elongation product of γ-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized...

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Biovision | BAY-1816032 | B2750

BAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM. Displays excellent selectivity over a panel of 395 kinases. BAY...

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Biovision | LLY-283 | B2749

LLY-283 is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 22 nM). It is selective for PRMT5 over a panel of 32 methyltransferases, including PRMT4, -6, and -7 at 1...

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Biovision | ASP-4132 tosylate | B2748

ASP-4132 is a potent AMPK activator with potential antineoplastic activity. Upon oral administration, ASP4132 affects oxidative phosphorylation in mitochondria of metabolically-active tumor cells,...

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Biovision | BSJ-03-123 | B2747

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC). BSJ-03-123 causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest...

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Biovision | SBI-797812 | B2746

SBI-797812 is a novel nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these inhibitors to...

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Biovision | GSK-3368715 | B2745

GSK-3368715 is a potent, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4),...

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Biovision | Dexamethasone phosphate disodium | B2744

Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid anti-inflammatory agent dexamethasone (Cat. No. 1042). Recently, it has been shown that in patients hospitalized with...

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Biovision | AR-C155858 | B2743

AR-C155858 is a potent Inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and

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Biovision | DiI Stain | B2742

DiI is a widely used lipophilic, carbocyanine membrane dye that labels cell membranes by inserting its two long (C18 carbon) hydrocarbon chains into the lipid bilayer. This dye is used primarily for...

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