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Biovision

  • FB23-2

    Biovision | FB23-2 | B2740

    FB23-2 is a potent FTO (fat mass and obesity-associated) inhibitor. FB23-2 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity (IC50 = 2.6 µM). Mimicking FTO depletion,...

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  • IOX3 (FG-2216)

    Biovision | IOX3 (FG-2216) | B2739

    IOX3 (FG-2216) is a potent, orally bioavailable HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.9 µM for PDH2 enzyme. It has been shown to reversibly stimulate erythropoietin secretion at 100...

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  • Rhein

    Biovision | Rhein | B2737

    Rhein is an anthraquinone derivative that displays diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities. Also acts as a Fat mass and obesity-associated...

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  • Ketoconazole

    Biovision | Ketoconazole | B2735

    Ketoconazole is a broad-spectrum triazole antifungal agent. It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol biosynthesis...

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  • Vipadenant

    Biovision | Vipadenant | B2734

    Vipadenant is a selective adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively. Vipadenant also reverses haloperidol-induced hypolocomotion in mice and rats...

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  • Adapalene

    Biovision | Adapalene | B2733

    Adapalene is a synthetic Retinoic acid analog that acts as a RARβ and RARγ agonist (AC₅₀ values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits...

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  • RG7834

    Biovision | RG7834 | B2732

    RG7834 is a highly selective and orally bioavailable HBV (Hepatitis B Virus) inhibitor, that potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC₅₀s of 2.8, 2.6, and 3.2 nM,...

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  • CADD522

    Biovision | CADD522 | B2731

    CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC₅₀ of 10 nM. CADD522 treatment results in significant growth inhibition, clonogenic survival, and...

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  • ML-277

    Biovision | ML-277 | B2730

    ML-277 is a potent activator of KCNQ1 (Kv7.1) channels (EC₅₀ = 260nM). It displays >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1...

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  • LY-3381916

    Biovision | LY-3381916 | B2729

    LY-3381916 is a potent, selective and brain permeant IDO1 (Indoleamine 2,3-Dioxygenase1) inhibitor. LY-3381916 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation...

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  • EIDD-2801

    Biovision | EIDD-2801 | B2725

    EIDD-2801 is an orally bioavailable prodrug of the potent ribonucleoside analog EIDD-1931. EIDD-2801 displays broad spectrum antiviral activity against influenza virus and multiple coronaviruses,...

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  • Prostratin

    Biovision | Prostratin | B2724

    Prostratin is a terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrata. Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic...

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  • SSAA09E2

    Biovision | SSAA09E2 | B2723

    SSAA09E2 is a novel inhibitor of SARS-CoV (Severe acute respiratory syndrome-Coronavirus) replication, acting by blocking early interactions of SARS-S with the receptor for SARS-CoV, Angiotensin...

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  • SSAA09E1

    Biovision | SSAA09E1 | B2722

    SSAA09E1 is a novel inhibitor of SARS-CoV (Severe acute respiratory syndrome-Coronavirus) replication, acting by blocking cathepsin L, a host protease required for processing of SARS-S during viral...

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  • 5-Iodotubercidin

    Biovision | 5-Iodotubercidin | B2721

    5-Iodotubercidin is a potent adenosine kinase inhibitor (IC₅₀ = 26 nM). 5-Iodotubercidin initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation...

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  • GNF-4877

    Biovision | GNF-4877 | B2720

    GNF-4877 is a potent inhibitor of Dyrk1a (IC₅₀ = 6 nM) and GSK-3β (IC₅₀ = 16 nM), that promotes pancreatic β cell proliferation in rodent and human primary islets.GNF-4877 is a potent inhibitor of...

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  • AM-251

    Biovision | AM-251 | B2718

    AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC50 of 8 nM. It also acts as an agonist at GPR55 (EC50 = 39 nM) and potentiates GABAA receptor currents (EC50 = 0.4 µM). In mice,...

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  • Withaferin A

    Biovision | Withaferin A | B2716

    Withaferin A is a steroid lactone that displays potent anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50 = 12 nM) and in vivo...

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  • N6-Methyladenosine

    Biovision | N6-Methyladenosine | B2715

    N6-Methyladenosine is an adenosine analog that inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta. It decreases arterial blood pressure and renal blood flow and...

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  • AMZ30

    Biovision | AMZ30 | B2714

    AMZ30 is a potent, selective, and covalent inhibitor of protein phosphatase methylesterase-1(PME-1; IC50 = 600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living...

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  • Clofazimine

    Biovision | Clofazimine | B2712

    Clofazimine is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It displays anti-inflammatory...

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  • ABTS™ (solid)

    Biovision | ABTS™ (solid) | B2711

    ABTS is considered a safe and sensitive substrate compatible for horseradish peroxidase (HRP) based ELISA assays. In the presence of hydrogen peroxide and HRP, ABTS is oxidized to a radical cation...

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  • ML-210

    Biovision | ML-210 | B2710

    ML-210 is a selective and covalent inhibitor of glutathione peroxidase 4 (GPX4). ML-210 binds the GPX4 selenocysteine residue. It reduces viability of mesenchymal-state KP4 cells, an effect that can...

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  • GSK-2983559

    Biovision | GSK-2983559 | B2709

    GSK-2983559 is a potent and selective inhibitor of receptor interacting protein-2 (RIP2) kinase.GSK-2983559 is a potent and selective inhibitor of receptor interacting protein-2 (RIP2) kinase...

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  • Adaptaquin

    Biovision | Adaptaquin | B2706

    Adaptaquin is a brain-permeable hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) inhibitor. It stabilizes HIF-1α protein and induces expression of the HIF-1-regulated genes EPO and VEGF in...

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  • Merimepodib

    Biovision | Merimepodib | B2705

    Merimepodib (VX-497) is a novel noncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH). Merimepodib is orally bioavailable and inhibits the proliferation of primary human, mouse,...

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  • Penciclovir

    Biovision | Penciclovir | B2704

    Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. It displays activity against multiple laboratory...

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  • Etravirine

    Biovision | Etravirine | B2703

    Etravirine is an antiretroviral agent classified as a non-nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1...

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  • Didanosine

    Biovision | Didanosine | B2702

    Didanosine is a nucleoside analog that acts as a reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Didanosine is phosphorylated to active...

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  • Pidotimod

    Biovision | Pidotimod | B2701

    Pidotimod is a synthetic dipeptide with immunomodulatory properties. Pidotimod inhibits tumor necrosis factor α (TNF-α) induced increases in extracellular signal-related kinase (ERK) phosphorylation...

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  • Azlocillin sodium

    Biovision | Azlocillin sodium | B2700

    Azlocillin sodium is an acylampicillin that exhibits an extended-spectrum of activity and in vitro potency that is greater than that of the carboxy penicillins. Azlocillin is shown to be effective...

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  • Nitrofurantoin

    Biovision | Nitrofurantoin | B2698

    Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit...

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  • Furazolidone

    Biovision | Furazolidone | B2697

    Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase (MAO). It is used...

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  • Aztreonam

    Biovision | Aztreonam | B2696

    Aztreonam is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the...

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  • Telithromycin

    Biovision | Telithromycin | B2695

    Telithromycin is a semi-synthetic erythromycin derivative that belongs to a class of ketolide antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering...

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  • Troleandomycin

    Biovision | Troleandomycin | B2694

    Troleandomycin is a macrolide antibiotic similar to erythromycin (Cat. No. 9619). Inhibits cytochrome P450 (IC50 = 0-5 μM), thus blocking CYP450-dependent drug oxidation. It binds to the 50S subunit...

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  • Dirithromycin

    Biovision | Dirithromycin | B2693

    Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections. It is a group 3...

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  • Clarithromycin

    Biovision | Clarithromycin | B2692

    Clarithromycin is a semisynthetic macrolide antibiotic derived from erythromycin. It inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl...

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