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Biovision | VEGFR-2 inhibitor | B2938

VEGFR-2 inhibitor is a potent inhibitor of Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase (VEGFR-2). It shows 79% inhibition in the murine matrigel model for vascular permeability at...

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Biovision | ZXX2-77 | B2937

ZXX2-77 is a benzenesulfonanilide derivative that inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. It shows more potent analgesic activity than aspirin at 30 mg/kg by po. It can be used as a...

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Biovision | WAY-265497 | B2936

WAY-265497 is a potent ATP-binding site-targeting inhibitor of Cdk4/D1 kinase activity with an IC₅₀ of 30 nM. It inhibits HCT116 and MCF-7 cancer cells with IC₅₀ values of 0.73 and 0.88 µM,...

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Biovision | CK2 inhibitor | B2935

CK2 inhibitor selectively inhibits casein kinase 2 (CK2) with an IC₅₀ of 0.125 μM. CK2 is a potential protein kinase target for the development of antitumor, antiviral and anti-inflammatory drugs.CK2...

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Biovision | ROCK-II Inhibitor | B2934

ROCK Inhibitor-II inhibits the Rho kinase ROCK-II with an IC₅₀

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Biovision | HDAC, EGFR & HER2 inhibitor | B2933

HDAC, EGFR, and HER2 Inhibitor is a multitargeted inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with IC₅₀ values...

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Biovision | VEGFR-2 & tubulin inhibitor | B2932

VEGFR-2 and tubulin inhibitor inhibits polymerization of tubulin with an IC₅₀ of 1.1 μM. It inhibits the receptor tyrosine kinase VEGFR-2 in vitro and VEGFR-2 in cells with an IC₅₀ of 0.21 μM and 0...

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Biovision | BRD6929 | B2931

BRD6929 is a benzamide-based brain-penetrant inhibitor of Histone deacetylases HDAC1 and HDAC2. It increases histone acetylation and inhibits HDAC1 and HDAC2 with an IC₅₀ of 1 nM and 8 nM...

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Biovision | HDAC1&2 Inhibitor | B2930

HDAC1&2 inhibitor selectively inhibits Histone deacetylases HDAC1 and HDAC2 with an IC₅₀ of 10 nM and 105 nM for HDAC1 and HDAC2 respectively. It shows a GI₅₀ of 100 nM for HCT-116 cells.HDAC1&2...

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Biovision | CINK4 | B2929

CINK4 is a triaminopyrimidine derivative that inhibits Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC₅₀ values of 1.5 and 5.6 μM, respectively. It reduces retinoblastoma protein phosphorylation...

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Biovision | Cdk4 Inhibitor | B2928

Cdk4 Inhibitor is an indolocarbazole which is a potent, selective and ATP competitive cyclin D1/CDK4 inhibitor. It has an IC₅₀ value of 76 nM. It inhibits tumor cell growth, arrests tumor cells at...

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Biovision | TCS 21311 | B2927

TCS 21311 is a potent JAK3 (Janus kinase 3) inhibitor. It shows high selectivity for JAK3 over JAK1, JAK2 and TYK2 with IC₅₀ values of 8 nM, 1017 nM, 2550 nM and 8055 nM respectively. It also...

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Biovision | K-604, ACAT-1 Inhibitor | B2926

K-604 is an inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1). The IC₅₀ values of K-604 for human ACAT-1 and ACAT-2 are 0.45 μM and 102.85 μM respectively, showing that K-604 is 229-fold...

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Biovision | VUF 8430 dihydrobromide | B2925

VUF 8430 is a high affinity agonist (pKi = 7.5) for the histamine H4 receptor (pEC₅₀= 7.3). It is a moderate affinity agonist for the H3 receptor and is inactive at H1 and H2 receptor.VUF 8430 is a...

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Biovision | Nek2/Hec1 inhibitor | B2924

Nek2/Hec1 inhibitor targets the Hec1/Nek2 pathway and causes chromosome mis-alignment as well as cell death. The IC₅₀ for cytotoxicity in MDA-MB231, MDA-MB468, HeLa and K562 cell lines is 1.1 μM, 3.4...

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Biovision | SU 3327 | B2923

SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK). It shows an IC₅₀ of 0.7 μM in the kinase assay. It Inhibits the protein-protein interaction between JNK and JIP with an IC₅₀ of 239...

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Biovision | cFMS Receptor Inhibitor IV | B2922

cFMS Receptor Inhibitor IV is a furan carboxamide compound that is a potent, reversible, and ATP-competitive inhibitor of cFMS (Colony-stimulating Factor-1 Receptor) Tyrosine Kinase. It blocks cFMS...

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Biovision | Bifeprunox | B2921

Bifeprunox shows positive effects in treating psychotic symptoms in schizophrenia. It is a third-generation antipsychotic agent which acts as a partial agonist at dopamine D2 receptors and is an...

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Biovision | CK2 inhibitor | B2920

CK2 inhibitor is a 3-carboxy-4(1H)-quinolone which selectively inhibits casein kinase 2 (CK2) with an IC₅₀ value of 0.3 μM. It competitively inhibits binding of ATP with a Ki value of 0.06 µM.CK2...

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Biovision | MAO-A/MAO-B Inhibitor | B2919

MAO-A/MAO-B inhibitor is a coumarin derivative which inhibits monoamine oxidases MAO-A and MAO-B with an IC₅₀ of 235 ± 18.52 nM and 165 ± 7.04 nΜ, respectively.MAO-A/MAO-B inhibitor is a coumarin...

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Biovision | Syk Inhibitor II | B2918

Syk Inhibitor II is an ATP-competitive inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 41 nM. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk. It prevents FcεRI-mediated...

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Biovision | TGX-155 | B2917

TGX-155 is an inhibitor of phosphoinositide 3-kinase (PI3K). PI3Ks and their lipid product phosphatidylinositol-3,4,5-trisphosphate are involved in signaling events in many cellular processes...

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Biovision | BX-320 | B2916

BX-320 is an inhibitor of 3-phosphoinositide-dependent kinase-1 (PDK1). The phosphoinositide 3-kinase/PDK1/Akt signaling pathway plays an important role in cancer cell growth, survival and...

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Biovision | ZM306416 | B2915

ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. It inhibits the activity of KDR and Flt VEGF receptors with IC₅₀ values of 100 nM and 2 μM,...

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Biovision | CAY10602 | B2914

CAY10602 is an activator of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. SIRT1 alters gene expression by deacetylating transcription factors such as NF-κB, p53, and FOXO...

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Biovision | R112 | B2913

R112 is an inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 226 nM in cultured human mast cells. It is an ATP-competitive Syk inhibitor with a Ki of 96 nM. It completely and rapidly inhibits...

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Biovision | CAY10575 | B2912

CAY10575 is an inhibitor of IKK-ε. IKK-ε is a homolog of IKK-α and IKK-β which can activate NF-κB. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. CAY10575 is a...

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Biovision | NSC109116 | B2911

NSC109116 is an inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), an aldo-keto reductase (AKR) enzyme. AKR1C1 metabolizes progesterone to an inactive form, 20α-hydroxy progesterone...

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Biovision | NSC 210902 | B2910

NSC 210902 inhibits casein kinase 2 (CK2) with an IC₅₀ value of 1 μM. It competitively inhibits binding of ATP with a Ki value of 0.28 µM. It minimally inhibits protein kinases JNK3, GSK3, Cdk5, MSK1...

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Biovision | NH125 | B2909

NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria. It inhibits histidine protein kinase YycG with an IC₅₀ of 6.6 µM. It selectively inhibits eEF-2 kinase...

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Biovision | WHI-P180 | B2908

WHI-P180 is a multi-kinase inhibitor. It inhibits human proto-oncogene receptor tyrosine kinase RET (Rearranged during Transfection) and kinase insert domain receptor (KDR) with IC₅₀ values of 4.5 nM...

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Biovision | INH6 | B2907

INH6 is a potent inhibitor of Hec1/Nek2 which regulate the mitotic spindle formation together. It causes chromosome mis-alignment, apoptosis and cell death. It inhibits proliferation of MDA-MB231,...

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Biovision | Daidzein | B2906

Daidzein is an isoflavone phytoestrogen found in soybean, with antioxidant properties. It increases transactivation of estrogen receptor β-induced transcription. It binds to estrogen receptor β...

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Biovision | GW1100 | B2905

GW1100 is an antagonist for the free fatty acid receptor FFAR1 (GPR40). It inhibits GPR40-mediated Ca2+ elevations stimulated by GW 9508 (agonist for GPR40 and GPR120) and linoleic acid with pIC₅₀...

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Biovision | CAY10577 | B2904

CAY10577 is an inhibitor of Casein kinase 2 (CK2) with an IC₅₀ value of 0.8 µM. CK2 is a serine/threonine-selective protein kinase which is implicated in the development of some cancers, viral...

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Biovision | Cdk9 Inhibitor II | B2903

Cdk9 Inhibitor II is a potent and selective inhibitor of Cdk9 with an IC₅₀ value of 0.35 µM in vitro. It is also an inhibitor of Cdk2-cyclin E with respect to ATP, with Ki and IC₅₀ values of 13.3 µM...

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Biovision | Arcyriaflavin A | B2902

Arcyriaflavin A inhibits cyclin-dependent kinase 4 (CDK4) with an IC₅₀ of 140 nM. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC₅₀ of 25 nM. It inhibits the...

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Biovision | 4EGI-1 | B2901

4EGI-1 is an inhibitor of the interaction of translation initiation factor eIF4G to eIF4E. It inhibits the binding of eIF4G to eIF4E, but not 4E-BP1. The KD for eIF4E binding to 4EGI-1 is 25 μM ± 11...

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Biovision | RTA 408 | B2860

RTA 408 is a synthetic oleanane triterpenoid that activates Nrf2. RTA 408 activates Nrf2 and suppresses nitric oxide and pro-inflammatory cytokine levels in interferon-γ-stimulated RAW 264.7...

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Biovision | L002 | B2859

L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is...

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Biovision | YW3-56 (hydrochloride) | B2858

YW3-56 is an inhibitor of protein arginine deiminases PAD2 and PAD4 which convert protein arginine residues to citrulline. The IC₅₀ for inhibition of PAD4 and PAD2 is about 1–2 μM and 0.5–1 μM...

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Biovision | I-BRD9 | B2857

I-BRD9 is an inhibitor and chemical probe for BRD9 bromodomain. BRD9 (bromodomain-containing protein 9) is a part of the chromatin remodeling SWI/SNF BAF complex. Bromodomain "reader" modules...

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Biovision | TC-E 5002 | B2856

TC-E 5002 is an inhibitor of the histone lysine demethylase (KDM) subfamily KDM2/7. It potently inhibits KDM2A, KDM7A and KDM7B with an IC₅₀ of 6.8 μM, 0.2 μM and 1.2 μM respectively. It inhibits the...

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Biovision | Tasquinimod | B2855

Tasquinimod has anti-angiogenic, antitumor and immune-modulatory properties. It shows consistent anti-angiogenic activity in vitro at doses between 10-50 μM. The mechanism of action of tasquinimod is...

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Biovision | NI-57 | B2854

NI-57 is an inhibitor of the bromodomains of BRPF proteins. The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment and activation...

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Biovision | LP99 | B2853

LP99 is an inhibitor of BRD9 and BRD7 bromodomains. LP99 inhibits the interactions of both BRD7 and BRD9 with histones H3.3 and H4, with IC₅₀ values in the low micromolar range in bioluminescence...

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Biovision | Resminostat (hydrochloride) | B2852

Resminostat is a potent inhibitor of histone deacetylases (HDAC) 1, 3 and 6 with IC₅₀ ranging from 43–72 nM. It induces hyperacetylation of histone H4, abrogates cell growth and induces apoptosis in...

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Biovision | MS37452 | B2851

MS37452 is a competitive inhibitor of CBX7 (Chromobox homolog 7) chromodomain binding to trimethylated lysine 27 of histone 3 (H3K27me3). It inhibits CBX7-H3K27me3 binding with a Ki of 43.0 μM. At...

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Biovision | XY1 | B2850

XY1 is an inactive control of SGC707. SGC707 is a potent, selective and allosteric inhibitor of Protein arginine methyltransferase3 (PRMT3) with an IC₅₀ of 31 nM. It inhibits the methylation of...

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Biovision | VLX600 | B2849

VLX600 is a small molecule which is cytotoxic to quiescent cells in colon cancer cells with an IC₅₀ of 1-10 μM. VLX600 decreases mitochondrial oxidative phosphorylation and shows enhanced cytotoxic...

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Biovision | UMB-32 | B2848

UMB-32 is an inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L. UMB-32 binds BRD4 with a Kd of 550 nM and the EC₅₀ is 724 nM in BRD4-dependent...

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Biovision | BB-Cl-Amidine | B2847

BB-Cl-Amidine is a pan-peptidylarginine deiminase (PAD) inhibitor. Peptidylarginine deiminase catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline. BB-Cl-Amidine is a derivative...

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